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MGAT1 (mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase)

Identity

Alias_names3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
MGAT
GLYT1
Alias_symbol (synonym)GNT-1
GLCNAC-TI
GnTI
Other aliasGLCT1
GNT-I
HGNC (Hugo) MGAT1
LocusID (NCBI) 4245
Atlas_Id 53198
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 180790541 and ends at 180810137 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MGAT1 (5q35.3) / DCAF8 (1q23.2)MGAT1 (5q35.3) / FLT4 (5q35.3)MGAT1 (5q35.3) / MGAT1 (5q35.3)
SLC2A10 (20q13.12) / MGAT1 (5q35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MGAT1   7044
Cards
Entrez_Gene (NCBI)MGAT1  4245  mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
AliasesGLCNAC-TI; GLCT1; GLYT1; GNT-1; 
GNT-I; GnTI; MGAT
GeneCards (Weizmann)MGAT1
Ensembl hg19 (Hinxton)ENSG00000131446 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131446 [Gene_View]  chr5:180790541-180810137 [Contig_View]  MGAT1 [Vega]
ICGC DataPortalENSG00000131446
TCGA cBioPortalMGAT1
AceView (NCBI)MGAT1
Genatlas (Paris)MGAT1
WikiGenes4245
SOURCE (Princeton)MGAT1
Genetics Home Reference (NIH)MGAT1
Genomic and cartography
GoldenPath hg38 (UCSC)MGAT1  -     chr5:180790541-180810137 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGAT1  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblMGAT1 - 5q35.3 [CytoView hg19]  MGAT1 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIMGAT1 [Mapview hg19]  MGAT1 [Mapview hg38]
OMIM160995   
Gene and transcription
Genbank (Entrez)AB209239 AF289558 AK057194 AK075429 AK090523
RefSeq transcript (Entrez)NM_001114617 NM_001114618 NM_001114619 NM_001114620 NM_002406
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MGAT1
Cluster EST : UnigeneHs.519818 [ NCBI ]
CGAP (NCI)Hs.519818
Alternative Splicing GalleryENSG00000131446
Gene ExpressionMGAT1 [ NCBI-GEO ]   MGAT1 [ EBI - ARRAY_EXPRESS ]   MGAT1 [ SEEK ]   MGAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)MGAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4245
GTEX Portal (Tissue expression)MGAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26572   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26572  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26572
Splice isoforms : SwissVarP26572
Catalytic activity : Enzyme2.4.1.101 [ Enzyme-Expasy ]   2.4.1.1012.4.1.101 [ IntEnz-EBI ]   2.4.1.101 [ BRENDA ]   2.4.1.101 [ KEGG ]   
PhosPhoSitePlusP26572
Domains : Interpro (EBI)Glyco_trans_13    Nucleotide-diphossugar_trans   
Domain families : Pfam (Sanger)GNT-I (PF03071)   
Domain families : Pfam (NCBI)pfam03071   
Conserved Domain (NCBI)MGAT1
DMDM Disease mutations4245
Blocks (Seattle)MGAT1
SuperfamilyP26572
Human Protein AtlasENSG00000131446
Peptide AtlasP26572
HPRD01189
IPIIPI00000138   IPI00179044   IPI00103810   IPI00965858   IPI00964457   IPI00964148   IPI00964985   IPI00964676   IPI00967770   IPI00965361   IPI00964058   
Protein Interaction databases
DIP (DOE-UCLA)P26572
IntAct (EBI)P26572
FunCoupENSG00000131446
BioGRIDMGAT1
STRING (EMBL)MGAT1
ZODIACMGAT1
Ontologies - Pathways
QuickGOP26572
Ontology : AmiGOGolgi membrane  in utero embryonic development  alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity  carbohydrate metabolic process  UDP-N-acetylglucosamine catabolic process  protein glycosylation  acetylglucosaminyltransferase activity  membrane  integral component of membrane  metal ion binding  extracellular exosome  extracellular vesicle  
Ontology : EGO-EBIGolgi membrane  in utero embryonic development  alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity  carbohydrate metabolic process  UDP-N-acetylglucosamine catabolic process  protein glycosylation  acetylglucosaminyltransferase activity  membrane  integral component of membrane  metal ion binding  extracellular exosome  extracellular vesicle  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkMGAT1
Atlas of Cancer Signalling NetworkMGAT1
Wikipedia pathwaysMGAT1
Orthology - Evolution
OrthoDB4245
GeneTree (enSembl)ENSG00000131446
Phylogenetic Trees/Animal Genes : TreeFamMGAT1
HOVERGENP26572
HOGENOMP26572
Homologs : HomoloGeneMGAT1
Homology/Alignments : Family Browser (UCSC)MGAT1
Gene fusions - Rearrangements
Fusion : MitelmanMGAT1/FLT4 [5q35.3/5q35.3]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGAT1
dbVarMGAT1
ClinVarMGAT1
1000_GenomesMGAT1 
Exome Variant ServerMGAT1
ExAC (Exome Aggregation Consortium)MGAT1 (select the gene name)
Genetic variants : HAPMAP4245
Genomic Variants (DGV)MGAT1 [DGVbeta]
DECIPHERMGAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGAT1 
Mutations
ICGC Data PortalMGAT1 
TCGA Data PortalMGAT1 
Broad Tumor PortalMGAT1
OASIS PortalMGAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMGAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch MGAT1
DgiDB (Drug Gene Interaction Database)MGAT1
DoCM (Curated mutations)MGAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGAT1 (select a term)
intoGenMGAT1
Cancer3DMGAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM160995   
Orphanet
MedgenMGAT1
Genetic Testing Registry MGAT1
NextProtP26572 [Medical]
TSGene4245
GENETestsMGAT1
Huge Navigator MGAT1 [HugePedia]
snp3D : Map Gene to Disease4245
BioCentury BCIQMGAT1
ClinGenMGAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4245
Chemical/Pharm GKB GenePA30779
Clinical trialMGAT1
Miscellaneous
canSAR (ICR)MGAT1 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGAT1
EVEXMGAT1
GoPubMedMGAT1
iHOPMGAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:48 CEST 2017

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