MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase)

2014-11-01  

Identity

HGNC
LOCATION
14q21.3
LOCUSID
ALIAS
CDG2A,CDGS2,GLCNACTII,GNT-II,GNT2

Other Information

Locus ID:

NCBI: 4247
MIM: 602616
HGNC: 7045
Ensembl: ENSG00000168282

Variants:

dbSNP: 4247
ClinVar: 4247
TCGA: ENSG00000168282
COSMIC: MGAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168282ENST00000305386Q10469

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the complex N-glycan synthesis pathwayREACTOMER-HSA-975578

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203785512010Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.35
259449012015UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).11
296662722018Human <i>N</i>-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.7
294096972018Heterologous expression, purification and characterization of human β-1,2-N-acetylglucosaminyltransferase II using a silkworm-based Bombyx mori nucleopolyhedrovirus bacmid expression system.0

Citation

Dessen P

MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68950/mgat2