MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase)

2010-07-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
GNT-III,GNT3
FUSION GENES

Other Information

Locus ID:

NCBI: 4248
MIM: 604621
HGNC: 7046
Ensembl: ENSG00000128268

Variants:

dbSNP: 4248
ClinVar: 4248
TCGA: ENSG00000128268
COSMIC: MGAT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128268ENST00000341184Q09327
ENSG00000128268ENST00000418314B0QY92
ENSG00000128268ENST00000429402B0QY93

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the hybrid N-glycan synthesis pathwayREACTOMER-HSA-975574

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
149989992004Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.53
194035582009The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.34
236719302013E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.31
224516562012Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines.28
192760772009An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III.23
268016112016Expression of N-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels.14
197760782010Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease.13
274291952016Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients.13
124277582003Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells.10
213683802011MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer's disease by vitamin D and curcuminoids.10

Citation

Dessen P

MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51544/mgat3