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MGAT4A (mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A)

Identity

Alias_namesmannosyl (alpha-1
Alias_symbol (synonym)GnT-Iva
GnT-4a
Other aliasGNT-IV
GNT-IVA
HGNC (Hugo) MGAT4A
LocusID (NCBI) 11320
Atlas_Id 43659
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 99235569 and ends at 99279936 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AUTS2 (7q11.22) / MGAT4A (2q11.2)INPP4A (2q11.2) / MGAT4A (2q11.2)MGAT4A (2q11.2) / CXCR4 (2q22.1)
MGAT4A (2q11.2) / KIAA1211L (2q11.2)INPP4A 2q11.2 / MGAT4A 2q11.2MGAT4A 2q11.2 C2orf55

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MGAT4A   7047
Cards
Entrez_Gene (NCBI)MGAT4A  11320  mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
AliasesGNT-IV; GNT-IVA; GnT-4a
GeneCards (Weizmann)MGAT4A
Ensembl hg19 (Hinxton)ENSG00000071073 [Gene_View]  chr2:99235569-99279936 [Contig_View]  MGAT4A [Vega]
Ensembl hg38 (Hinxton)ENSG00000071073 [Gene_View]  chr2:99235569-99279936 [Contig_View]  MGAT4A [Vega]
ICGC DataPortalENSG00000071073
TCGA cBioPortalMGAT4A
AceView (NCBI)MGAT4A
Genatlas (Paris)MGAT4A
WikiGenes11320
SOURCE (Princeton)MGAT4A
Genetics Home Reference (NIH)MGAT4A
Genomic and cartography
GoldenPath hg19 (UCSC)MGAT4A  -     chr2:99235569-99279936 -  2q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MGAT4A  -     2q11.2   [Description]    (hg38-Dec_2013)
EnsemblMGAT4A - 2q11.2 [CytoView hg19]  MGAT4A - 2q11.2 [CytoView hg38]
Mapping of homologs : NCBIMGAT4A [Mapview hg19]  MGAT4A [Mapview hg38]
OMIM604623   
Gene and transcription
Genbank (Entrez)AB000616 AK092952 AK128366 AK291533 AK304393
RefSeq transcript (Entrez)NM_001160154 NM_012214
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929303
Consensus coding sequences : CCDS (NCBI)MGAT4A
Cluster EST : UnigeneHs.177576 [ NCBI ]
CGAP (NCI)Hs.177576
Alternative Splicing GalleryENSG00000071073
Gene ExpressionMGAT4A [ NCBI-GEO ]   MGAT4A [ EBI - ARRAY_EXPRESS ]   MGAT4A [ SEEK ]   MGAT4A [ MEM ]
Gene Expression Viewer (FireBrowse)MGAT4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11320
GTEX Portal (Tissue expression)MGAT4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UM21   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UM21  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UM21
Splice isoforms : SwissVarQ9UM21
Catalytic activity : Enzyme2.4.1.145 [ Enzyme-Expasy ]   2.4.1.1452.4.1.145 [ IntEnz-EBI ]   2.4.1.145 [ BRENDA ]   2.4.1.145 [ KEGG ]   
PhosPhoSitePlusQ9UM21
Domains : Interpro (EBI)Glyco_transf_54   
Domain families : Pfam (Sanger)Glyco_transf_54 (PF04666)   
Domain families : Pfam (NCBI)pfam04666   
Conserved Domain (NCBI)MGAT4A
DMDM Disease mutations11320
Blocks (Seattle)MGAT4A
SuperfamilyQ9UM21
Human Protein AtlasENSG00000071073
Peptide AtlasQ9UM21
HPRD06860
IPIIPI00016743   IPI00908866   
Protein Interaction databases
DIP (DOE-UCLA)Q9UM21
IntAct (EBI)Q9UM21
FunCoupENSG00000071073
BioGRIDMGAT4A
STRING (EMBL)MGAT4A
ZODIACMGAT4A
Ontologies - Pathways
QuickGOQ9UM21
Ontology : AmiGOGolgi membrane  N-glycan processing  alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity  integral component of membrane  metal ion binding  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  N-glycan processing  alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity  integral component of membrane  metal ion binding  extracellular exosome  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkMGAT4A
Atlas of Cancer Signalling NetworkMGAT4A
Wikipedia pathwaysMGAT4A
Orthology - Evolution
OrthoDB11320
GeneTree (enSembl)ENSG00000071073
Phylogenetic Trees/Animal Genes : TreeFamMGAT4A
HOVERGENQ9UM21
HOGENOMQ9UM21
Homologs : HomoloGeneMGAT4A
Homology/Alignments : Family Browser (UCSC)MGAT4A
Gene fusions - Rearrangements
Fusion : MitelmanINPP4A/MGAT4A [2q11.2/2q11.2]  [t(2;2)(q11;q11)]  
Fusion : MitelmanMGAT4A/CXCR4 [2q11.2/2q22.1]  [t(2;2)(q11;q22)]  
Fusion : MitelmanMGAT4A/KIAA1211L [2q11.2/2q11.2]  [t(2;2)(q11;q11)]  
Fusion: TCGAINPP4A 2q11.2 MGAT4A 2q11.2 BLCA
Fusion: TCGAMGAT4A 2q11.2 C2orf55 BRCA LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGAT4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGAT4A
dbVarMGAT4A
ClinVarMGAT4A
1000_GenomesMGAT4A 
Exome Variant ServerMGAT4A
ExAC (Exome Aggregation Consortium)MGAT4A (select the gene name)
Genetic variants : HAPMAP11320
Genomic Variants (DGV)MGAT4A [DGVbeta]
DECIPHER (Syndromes)2:99235569-99279936  ENSG00000071073
CONAN: Copy Number AnalysisMGAT4A 
Mutations
ICGC Data PortalMGAT4A 
TCGA Data PortalMGAT4A 
Broad Tumor PortalMGAT4A
OASIS PortalMGAT4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGAT4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMGAT4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MGAT4A
DgiDB (Drug Gene Interaction Database)MGAT4A
DoCM (Curated mutations)MGAT4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGAT4A (select a term)
intoGenMGAT4A
Cancer3DMGAT4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604623   
Orphanet
MedgenMGAT4A
Genetic Testing Registry MGAT4A
NextProtQ9UM21 [Medical]
TSGene11320
GENETestsMGAT4A
Huge Navigator MGAT4A [HugePedia]
snp3D : Map Gene to Disease11320
BioCentury BCIQMGAT4A
ClinGenMGAT4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11320
Chemical/Pharm GKB GenePA30782
Clinical trialMGAT4A
Miscellaneous
canSAR (ICR)MGAT4A (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGAT4A
EVEXMGAT4A
GoPubMedMGAT4A
iHOPMGAT4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:15:06 CET 2017

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