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MGEA5 (meningioma expressed antigen 5 (hyaluronidase))

Identity

Alias_symbol (synonym)MEA5
NCOAT
OGA
Other alias
HGNC (Hugo) MGEA5
LocusID (NCBI) 10724
Atlas_Id 41359
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 101784443 and ends at 101818465 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MGEA5 (10q24.32) / MGEA5 (10q24.32)MGEA5 (10q24.32) / PCGF1 (2p13.1)MGEA5 (10q24.32) / RNLS (10q23.31)
MGEA5 (10q24.32) / SLC36A1 (5q33.1)MGEA5 (10q24.32) / ZC3HAV1 (7q34)PABPC1 (8q22.3) / MGEA5 (10q24.32)
SERINC1 (6q22.31) / MGEA5 (10q24.32)TGFBR3 (1p22.1) / MGEA5 (10q24.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Soft tissue tumors: an overview
Soft Tissues: Myxoinflammatory fibroblastic sarcoma with t(1;10)(p22;q24) FGF8/


External links

Nomenclature
HGNC (Hugo)MGEA5   7056
Cards
Entrez_Gene (NCBI)MGEA5  10724  meningioma expressed antigen 5 (hyaluronidase)
AliasesMEA5; NCOAT; OGA
GeneCards (Weizmann)MGEA5
Ensembl hg19 (Hinxton)ENSG00000198408 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198408 [Gene_View]  chr10:101784443-101818465 [Contig_View]  MGEA5 [Vega]
ICGC DataPortalENSG00000198408
TCGA cBioPortalMGEA5
AceView (NCBI)MGEA5
Genatlas (Paris)MGEA5
WikiGenes10724
SOURCE (Princeton)MGEA5
Genetics Home Reference (NIH)MGEA5
Genomic and cartography
GoldenPath hg38 (UCSC)MGEA5  -     chr10:101784443-101818465 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGEA5  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblMGEA5 - 10q24.32 [CytoView hg19]  MGEA5 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBIMGEA5 [Mapview hg19]  MGEA5 [Mapview hg38]
OMIM604039   
Gene and transcription
Genbank (Entrez)AB014579 AF036144 AF307332 AK000988 AK002091
RefSeq transcript (Entrez)NM_001142434 NM_012215
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MGEA5
Cluster EST : UnigeneHs.500842 [ NCBI ]
CGAP (NCI)Hs.500842
Alternative Splicing GalleryENSG00000198408
Gene ExpressionMGEA5 [ NCBI-GEO ]   MGEA5 [ EBI - ARRAY_EXPRESS ]   MGEA5 [ SEEK ]   MGEA5 [ MEM ]
Gene Expression Viewer (FireBrowse)MGEA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10724
GTEX Portal (Tissue expression)MGEA5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60502   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60502  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60502
Splice isoforms : SwissVarO60502
PhosPhoSitePlusO60502
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    Beta-N-acetylglucosaminidase    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)NAGidase (PF07555)   
Domain families : Pfam (NCBI)pfam07555   
Conserved Domain (NCBI)MGEA5
DMDM Disease mutations10724
Blocks (Seattle)MGEA5
PDB (SRS)2YDQ   
PDB (PDBSum)2YDQ   
PDB (IMB)2YDQ   
PDB (RSDB)2YDQ   
Structural Biology KnowledgeBase2YDQ   
SCOP (Structural Classification of Proteins)2YDQ   
CATH (Classification of proteins structures)2YDQ   
SuperfamilyO60502
Human Protein AtlasENSG00000198408
Peptide AtlasO60502
HPRD04949
IPIIPI00465449   IPI00911066   IPI00181391   IPI00477231   IPI00640090   
Protein Interaction databases
DIP (DOE-UCLA)O60502
IntAct (EBI)O60502
FunCoupENSG00000198408
BioGRIDMGEA5
STRING (EMBL)MGEA5
ZODIACMGEA5
Ontologies - Pathways
QuickGOO60502
Ontology : AmiGOhyalurononglucosaminidase activity  nucleus  cytosol  N-acetylglucosamine metabolic process  protein O-linked glycosylation  glycoprotein catabolic process  protein deglycosylation  membrane  beta-N-acetylglucosaminidase activity  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity  
Ontology : EGO-EBIhyalurononglucosaminidase activity  nucleus  cytosol  N-acetylglucosamine metabolic process  protein O-linked glycosylation  glycoprotein catabolic process  protein deglycosylation  membrane  beta-N-acetylglucosaminidase activity  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity  
NDEx NetworkMGEA5
Atlas of Cancer Signalling NetworkMGEA5
Wikipedia pathwaysMGEA5
Orthology - Evolution
OrthoDB10724
GeneTree (enSembl)ENSG00000198408
Phylogenetic Trees/Animal Genes : TreeFamMGEA5
HOVERGENO60502
HOGENOMO60502
Homologs : HomoloGeneMGEA5
Homology/Alignments : Family Browser (UCSC)MGEA5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGEA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGEA5
dbVarMGEA5
ClinVarMGEA5
1000_GenomesMGEA5 
Exome Variant ServerMGEA5
ExAC (Exome Aggregation Consortium)MGEA5 (select the gene name)
Genetic variants : HAPMAP10724
Genomic Variants (DGV)MGEA5 [DGVbeta]
DECIPHERMGEA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGEA5 
Mutations
ICGC Data PortalMGEA5 
TCGA Data PortalMGEA5 
Broad Tumor PortalMGEA5
OASIS PortalMGEA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGEA5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMGEA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MGEA5
DgiDB (Drug Gene Interaction Database)MGEA5
DoCM (Curated mutations)MGEA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGEA5 (select a term)
intoGenMGEA5
Cancer3DMGEA5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604039   
Orphanet
MedgenMGEA5
Genetic Testing Registry MGEA5
NextProtO60502 [Medical]
TSGene10724
GENETestsMGEA5
Huge Navigator MGEA5 [HugePedia]
snp3D : Map Gene to Disease10724
BioCentury BCIQMGEA5
ClinGenMGEA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10724
Chemical/Pharm GKB GenePA30787
Clinical trialMGEA5
Miscellaneous
canSAR (ICR)MGEA5 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGEA5
EVEXMGEA5
GoPubMedMGEA5
iHOPMGEA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:24:50 CEST 2017

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