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MGLL (monoglyceride lipase)

Identity

Alias (NCBI)HU-K5
HUK5
MAGL
MGL
HGNC (Hugo) MGLL
HGNC Alias symbHU-K5
MGL
MAGL
HGNC Alias namemonoacylglycerol lipase
LocusID (NCBI) 11343
Atlas_Id 51356
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 127689062 and ends at 127822882 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FLNA (Xq28) / MGLL (3q21.3)MGLL (3q21.3) / ANAPC13 (3q22.2)MGLL (3q21.3) / HDLBP (2q37.3)
MGLL (3q21.3) / MGLL (3q21.3)MGLL (3q21.3) / SLCO2A1 (3q22.1)TSNARE1 (8q24.3) / MGLL (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MGLL   17038
Cards
Entrez_Gene (NCBI)MGLL    monoglyceride lipase
AliasesHU-K5; HUK5; MAGL; MGL
GeneCards (Weizmann)MGLL
Ensembl hg19 (Hinxton)ENSG00000074416 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074416 [Gene_View]  ENSG00000074416 [Sequence]  chr3:127689062-127822882 [Contig_View]  MGLL [Vega]
ICGC DataPortalENSG00000074416
TCGA cBioPortalMGLL
AceView (NCBI)MGLL
Genatlas (Paris)MGLL
SOURCE (Princeton)MGLL
Genetics Home Reference (NIH)MGLL
Genomic and cartography
GoldenPath hg38 (UCSC)MGLL  -     chr3:127689062-127822882 -  3q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGLL  -     3q21.3   [Description]    (hg19-Feb_2009)
GoldenPathMGLL - 3q21.3 [CytoView hg19]  MGLL - 3q21.3 [CytoView hg38]
ImmunoBaseENSG00000074416
Genome Data Viewer NCBIMGLL [Mapview hg19]  
OMIM609699   
Gene and transcription
Genbank (Entrez)AF131821 AI125141 AI379999 AJ270950 AK025983
RefSeq transcript (Entrez)NM_001003794 NM_001256585 NM_001388312 NM_001388313 NM_001388314 NM_001388315 NM_001388316 NM_001388317 NM_001388318 NM_007283
Consensus coding sequences : CCDS (NCBI)MGLL
Gene ExpressionMGLL [ NCBI-GEO ]   MGLL [ EBI - ARRAY_EXPRESS ]   MGLL [ SEEK ]   MGLL [ MEM ]
Gene Expression Viewer (FireBrowse)MGLL [ Firebrowse - Broad ]
GenevisibleExpression of MGLL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11343
GTEX Portal (Tissue expression)MGLL
Human Protein AtlasENSG00000074416-MGLL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99685   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99685  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99685
PhosPhoSitePlusQ99685
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)   
Domains : Interpro (EBI)AB_hydrolase    AB_hydrolase_1    Hydrolase_4   
Domain families : Pfam (Sanger)Hydrolase_4 (PF12146)   
Domain families : Pfam (NCBI)pfam12146   
Conserved Domain (NCBI)MGLL
PDB (RSDB)3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
PDB Europe3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
PDB (PDBSum)3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
PDB (IMB)3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
Structural Biology KnowledgeBase3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
SCOP (Structural Classification of Proteins)3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
CATH (Classification of proteins structures)3HJU    3JW8    3JWE    3PE6    4UUQ    5ZUN    6AX1    6BQ0   
SuperfamilyQ99685
AlphaFold pdb e-kbQ99685   
Human Protein Atlas [tissue]ENSG00000074416-MGLL [tissue]
HPRD17574
Protein Interaction databases
DIP (DOE-UCLA)Q99685
IntAct (EBI)Q99685
BioGRIDMGLL
STRING (EMBL)MGLL
ZODIACMGLL
Ontologies - Pathways
QuickGOQ99685
Ontology : AmiGOlysophospholipase activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  lipid metabolic process  fatty acid biosynthetic process  inflammatory response  regulation of signal transduction  membrane  lipase activity  arachidonic acid metabolic process  triglyceride catabolic process  extrinsic component of membrane  acylglycerol acyl-chain remodeling  protein homodimerization activity  acylglycerol catabolic process  acylglycerol catabolic process  acylglycerol lipase activity  acylglycerol lipase activity  acylglycerol lipase activity  regulation of inflammatory response  regulation of sensory perception of pain  monoacylglycerol catabolic process  regulation of endocannabinoid signaling pathway  
Ontology : EGO-EBIlysophospholipase activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  lipid metabolic process  fatty acid biosynthetic process  inflammatory response  regulation of signal transduction  membrane  lipase activity  arachidonic acid metabolic process  triglyceride catabolic process  extrinsic component of membrane  acylglycerol acyl-chain remodeling  protein homodimerization activity  acylglycerol catabolic process  acylglycerol catabolic process  acylglycerol lipase activity  acylglycerol lipase activity  acylglycerol lipase activity  regulation of inflammatory response  regulation of sensory perception of pain  monoacylglycerol catabolic process  regulation of endocannabinoid signaling pathway  
Pathways : KEGGGlycerolipid metabolism    Retrograde endocannabinoid signaling   
NDEx NetworkMGLL
Atlas of Cancer Signalling NetworkMGLL
Wikipedia pathwaysMGLL
Orthology - Evolution
OrthoDB11343
GeneTree (enSembl)ENSG00000074416
Phylogenetic Trees/Animal Genes : TreeFamMGLL
Homologs : HomoloGeneMGLL
Homology/Alignments : Family Browser (UCSC)MGLL
Gene fusions - Rearrangements
Fusion : MitelmanMGLL/ANAPC13 [3q21.3/3q22.2]  
Fusion : MitelmanMGLL/SLCO2A1 [3q21.3/3q22.1]  
Fusion : QuiverMGLL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGLL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGLL
dbVarMGLL
ClinVarMGLL
MonarchMGLL
1000_GenomesMGLL 
Exome Variant ServerMGLL
GNOMAD BrowserENSG00000074416
Varsome BrowserMGLL
ACMGMGLL variants
VarityQ99685
Genomic Variants (DGV)MGLL [DGVbeta]
DECIPHERMGLL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGLL 
Mutations
ICGC Data PortalMGLL 
TCGA Data PortalMGLL 
Broad Tumor PortalMGLL
OASIS PortalMGLL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGLL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMGLL
Mutations and Diseases : HGMDMGLL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMGLL
DgiDB (Drug Gene Interaction Database)MGLL
DoCM (Curated mutations)MGLL
CIViC (Clinical Interpretations of Variants in Cancer)MGLL
Cancer3DMGLL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609699   
Orphanet
DisGeNETMGLL
MedgenMGLL
Genetic Testing Registry MGLL
NextProtQ99685 [Medical]
GENETestsMGLL
Target ValidationMGLL
Huge Navigator MGLL [HugePedia]
ClinGenMGLL
Clinical trials, drugs, therapy
MyCancerGenomeMGLL
Protein Interactions : CTDMGLL
Pharm GKB GenePA30789
PharosQ99685
Clinical trialMGLL
Miscellaneous
canSAR (ICR)MGLL
HarmonizomeMGLL
DataMed IndexMGLL
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMGLL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:28 CEST 2021

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