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MGLL (monoglyceride lipase)

Identity

Alias_symbol (synonym)HU-K5
MGL
Other aliasHUK5
MAGL
HGNC (Hugo) MGLL
LocusID (NCBI) 11343
Atlas_Id 51356
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 127689062 and ends at 127823250 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FLNA (Xq28) / MGLL (3q21.3)MGLL (3q21.3) / ANAPC13 (3q22.2)MGLL (3q21.3) / HDLBP (2q37.3)
MGLL (3q21.3) / MGLL (3q21.3)MGLL (3q21.3) / SLCO2A1 (3q22.1)TSNARE1 (8q24.3) / MGLL (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MGLL   17038
Cards
Entrez_Gene (NCBI)MGLL  11343  monoglyceride lipase
AliasesHU-K5; HUK5; MAGL; MGL
GeneCards (Weizmann)MGLL
Ensembl hg19 (Hinxton)ENSG00000074416 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074416 [Gene_View]  chr3:127689062-127823250 [Contig_View]  MGLL [Vega]
ICGC DataPortalENSG00000074416
TCGA cBioPortalMGLL
AceView (NCBI)MGLL
Genatlas (Paris)MGLL
WikiGenes11343
SOURCE (Princeton)MGLL
Genetics Home Reference (NIH)MGLL
Genomic and cartography
GoldenPath hg38 (UCSC)MGLL  -     chr3:127689062-127823250 -  3q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGLL  -     3q21.3   [Description]    (hg19-Feb_2009)
EnsemblMGLL - 3q21.3 [CytoView hg19]  MGLL - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBIMGLL [Mapview hg19]  MGLL [Mapview hg38]
OMIM609699   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001003794 NM_001256585 NM_007283
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MGLL
Cluster EST : UnigeneHs.277035 [ NCBI ]
CGAP (NCI)Hs.277035
Alternative Splicing GalleryENSG00000074416
Gene ExpressionMGLL [ NCBI-GEO ]   MGLL [ EBI - ARRAY_EXPRESS ]   MGLL [ SEEK ]   MGLL [ MEM ]
Gene Expression Viewer (FireBrowse)MGLL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11343
GTEX Portal (Tissue expression)MGLL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99685   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99685  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99685
Splice isoforms : SwissVarQ99685
PhosPhoSitePlusQ99685
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)   
Domains : Interpro (EBI)AB_hydrolase    AB_hydrolase_1    Hydrolase_4   
Domain families : Pfam (Sanger)Hydrolase_4 (PF12146)   
Domain families : Pfam (NCBI)pfam12146   
Conserved Domain (NCBI)MGLL
DMDM Disease mutations11343
Blocks (Seattle)MGLL
PDB (SRS)3HJU    3JW8    3JWE    3PE6    4UUQ   
PDB (PDBSum)3HJU    3JW8    3JWE    3PE6    4UUQ   
PDB (IMB)3HJU    3JW8    3JWE    3PE6    4UUQ   
PDB (RSDB)3HJU    3JW8    3JWE    3PE6    4UUQ   
Structural Biology KnowledgeBase3HJU    3JW8    3JWE    3PE6    4UUQ   
SCOP (Structural Classification of Proteins)3HJU    3JW8    3JWE    3PE6    4UUQ   
CATH (Classification of proteins structures)3HJU    3JW8    3JWE    3PE6    4UUQ   
SuperfamilyQ99685
Human Protein AtlasENSG00000074416
Peptide AtlasQ99685
HPRD17574
IPIIPI00455206   IPI01013572   IPI00790166   IPI00293590   IPI00748826   IPI00956319   IPI00945201   IPI00796800   
Protein Interaction databases
DIP (DOE-UCLA)Q99685
IntAct (EBI)Q99685
FunCoupENSG00000074416
BioGRIDMGLL
STRING (EMBL)MGLL
ZODIACMGLL
Ontologies - Pathways
QuickGOQ99685
Ontology : AmiGOlysophospholipase activity  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  lipid metabolic process  fatty acid biosynthetic process  inflammatory response  regulation of signal transduction  regulation of signal transduction  membrane  arachidonic acid metabolic process  triglyceride catabolic process  extrinsic component of membrane  acylglycerol acyl-chain remodeling  protein homodimerization activity  acylglycerol catabolic process  acylglycerol catabolic process  acylglycerol lipase activity  acylglycerol lipase activity  acylglycerol lipase activity  regulation of inflammatory response  regulation of sensory perception of pain  regulation of endocannabinoid signaling pathway  
Ontology : EGO-EBIlysophospholipase activity  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  lipid metabolic process  fatty acid biosynthetic process  inflammatory response  regulation of signal transduction  regulation of signal transduction  membrane  arachidonic acid metabolic process  triglyceride catabolic process  extrinsic component of membrane  acylglycerol acyl-chain remodeling  protein homodimerization activity  acylglycerol catabolic process  acylglycerol catabolic process  acylglycerol lipase activity  acylglycerol lipase activity  acylglycerol lipase activity  regulation of inflammatory response  regulation of sensory perception of pain  regulation of endocannabinoid signaling pathway  
Pathways : KEGGGlycerolipid metabolism    Retrograde endocannabinoid signaling   
NDEx NetworkMGLL
Atlas of Cancer Signalling NetworkMGLL
Wikipedia pathwaysMGLL
Orthology - Evolution
OrthoDB11343
GeneTree (enSembl)ENSG00000074416
Phylogenetic Trees/Animal Genes : TreeFamMGLL
HOVERGENQ99685
HOGENOMQ99685
Homologs : HomoloGeneMGLL
Homology/Alignments : Family Browser (UCSC)MGLL
Gene fusions - Rearrangements
Fusion : MitelmanMGLL/ANAPC13 [3q21.3/3q22.2]  
Fusion : MitelmanMGLL/SLCO2A1 [3q21.3/3q22.1]  [t(3;3)(q21;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGLL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGLL
dbVarMGLL
ClinVarMGLL
1000_GenomesMGLL 
Exome Variant ServerMGLL
ExAC (Exome Aggregation Consortium)MGLL (select the gene name)
Genetic variants : HAPMAP11343
Genomic Variants (DGV)MGLL [DGVbeta]
DECIPHERMGLL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGLL 
Mutations
ICGC Data PortalMGLL 
TCGA Data PortalMGLL 
Broad Tumor PortalMGLL
OASIS PortalMGLL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGLL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMGLL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MGLL
DgiDB (Drug Gene Interaction Database)MGLL
DoCM (Curated mutations)MGLL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGLL (select a term)
intoGenMGLL
Cancer3DMGLL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609699   
Orphanet
MedgenMGLL
Genetic Testing Registry MGLL
NextProtQ99685 [Medical]
TSGene11343
GENETestsMGLL
Target ValidationMGLL
Huge Navigator MGLL [HugePedia]
snp3D : Map Gene to Disease11343
BioCentury BCIQMGLL
ClinGenMGLL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11343
Chemical/Pharm GKB GenePA30789
Clinical trialMGLL
Miscellaneous
canSAR (ICR)MGLL (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGLL
EVEXMGLL
GoPubMedMGLL
iHOPMGLL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:57 CEST 2017

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