MGP (matrix Gla protein)

2014-08-01  

Identity

HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
GIG36,MGLAP,NTI
FUSION GENES

Other Information

Locus ID:

NCBI: 4256
MIM: 154870
HGNC: 7060
Ensembl: ENSG00000111341

Variants:

dbSNP: 4256
ClinVar: 4256
TCGA: ENSG00000111341
COSMIC: MGP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111341ENST00000228938P08493
ENSG00000111341ENST00000539261P08493
ENSG00000111341ENST00000539261A0A024RAX0
ENSG00000111341ENST00000545199H0YGZ6

Expression (GTEx)

0
5000
10000
15000

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA28660GGCXGenePathwayassociated

References

Pubmed IDYearTitleCitations
204790292010The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study.141
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
201334892010The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report.68
188412802008Matrix Gla-protein: the calcification inhibitor in need of vitamin K.66
178481782007Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.65
145870312003Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells.43
217652152011Matrix Gla protein deficiency causes arteriovenous malformations in mice.42
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
177244492007Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients.35
183691572008Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.35

Citation

Dessen P

MGP (matrix Gla protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54454/mgp