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MGST1 (microsomal glutathione S-transferase 1)

Identity

Alias_namesGST12
Alias_symbol (synonym)MGST-I
Other aliasMGST
HGNC (Hugo) MGST1
LocusID (NCBI) 4257
Atlas_Id 41361
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 16347142 and ends at 16364410 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MGST1 (12p12.3) / CRYZ (1p31.1)MGST1 (12p12.3) / MGST1 (12p12.3)MGST1 (12p12.3) / SRGAP2 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MGST1   7061
Cards
Entrez_Gene (NCBI)MGST1  4257  microsomal glutathione S-transferase 1
AliasesGST12; MGST; MGST-I
GeneCards (Weizmann)MGST1
Ensembl hg19 (Hinxton)ENSG00000008394 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008394 [Gene_View]  ENSG00000008394 [Sequence]  chr12:16347142-16364410 [Contig_View]  MGST1 [Vega]
ICGC DataPortalENSG00000008394
TCGA cBioPortalMGST1
AceView (NCBI)MGST1
Genatlas (Paris)MGST1
WikiGenes4257
SOURCE (Princeton)MGST1
Genetics Home Reference (NIH)MGST1
Genomic and cartography
GoldenPath hg38 (UCSC)MGST1  -     chr12:16347142-16364410 +  12p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGST1  -     12p12.3   [Description]    (hg19-Feb_2009)
EnsemblMGST1 - 12p12.3 [CytoView hg19]  MGST1 - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBIMGST1 [Mapview hg19]  MGST1 [Mapview hg38]
OMIM138330   
Gene and transcription
Genbank (Entrez)AA314967 AK123482 AK291148 AK309707 AV655242
RefSeq transcript (Entrez)NM_001260511 NM_001260512 NM_001267598 NM_020300 NM_145764 NM_145791 NM_145792
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MGST1
Cluster EST : UnigeneHs.389700 [ NCBI ]
CGAP (NCI)Hs.389700
Alternative Splicing GalleryENSG00000008394
Gene ExpressionMGST1 [ NCBI-GEO ]   MGST1 [ EBI - ARRAY_EXPRESS ]   MGST1 [ SEEK ]   MGST1 [ MEM ]
Gene Expression Viewer (FireBrowse)MGST1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4257
GTEX Portal (Tissue expression)MGST1
Human Protein AtlasENSG00000008394-MGST1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10620   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10620  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10620
Splice isoforms : SwissVarP10620
Catalytic activity : Enzyme2.5.1.18 [ Enzyme-Expasy ]   2.5.1.182.5.1.18 [ IntEnz-EBI ]   2.5.1.18 [ BRENDA ]   2.5.1.18 [ KEGG ]   
PhosPhoSitePlusP10620
Domains : Interpro (EBI)MAPEG-like_dom_sf    Membr-assoc_MAPEG   
Domain families : Pfam (Sanger)MAPEG (PF01124)   
Domain families : Pfam (NCBI)pfam01124   
Conserved Domain (NCBI)MGST1
DMDM Disease mutations4257
Blocks (Seattle)MGST1
SuperfamilyP10620
Human Protein Atlas [tissue]ENSG00000008394-MGST1 [tissue]
Peptide AtlasP10620
HPRD00705
IPIIPI00021805   IPI01014744   IPI01015983   IPI01015231   IPI00798081   IPI01014188   IPI01011894   
Protein Interaction databases
DIP (DOE-UCLA)P10620
IntAct (EBI)P10620
FunCoupENSG00000008394
BioGRIDMGST1
STRING (EMBL)MGST1
ZODIACMGST1
Ontologies - Pathways
QuickGOP10620
Ontology : AmiGOprostaglandin biosynthetic process  glutathione transferase activity  glutathione transferase activity  glutathione transferase activity  glutathione peroxidase activity  protein binding  nucleus  mitochondrion  mitochondrion  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  glutathione metabolic process  xenobiotic metabolic process  response to organonitrogen compound  integral component of membrane  response to lipopolysaccharide  Leydig cell differentiation  azurophil granule membrane  response to drug  protein homodimerization activity  glutathione binding  neutrophil degranulation  apical part of cell  prostaglandin-E synthase activity  oxidation-reduction process  oxidation-reduction process  protein homotrimerization  cellular response to lipid hydroperoxide  cellular oxidant detoxification  glutathione derivative biosynthetic process  
Ontology : EGO-EBIprostaglandin biosynthetic process  glutathione transferase activity  glutathione transferase activity  glutathione transferase activity  glutathione peroxidase activity  protein binding  nucleus  mitochondrion  mitochondrion  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  glutathione metabolic process  xenobiotic metabolic process  response to organonitrogen compound  integral component of membrane  response to lipopolysaccharide  Leydig cell differentiation  azurophil granule membrane  response to drug  protein homodimerization activity  glutathione binding  neutrophil degranulation  apical part of cell  prostaglandin-E synthase activity  oxidation-reduction process  oxidation-reduction process  protein homotrimerization  cellular response to lipid hydroperoxide  cellular oxidant detoxification  glutathione derivative biosynthetic process  
Pathways : KEGGGlutathione metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkMGST1
Atlas of Cancer Signalling NetworkMGST1
Wikipedia pathwaysMGST1
Orthology - Evolution
OrthoDB4257
GeneTree (enSembl)ENSG00000008394
Phylogenetic Trees/Animal Genes : TreeFamMGST1
HOVERGENP10620
HOGENOMP10620
Homologs : HomoloGeneMGST1
Homology/Alignments : Family Browser (UCSC)MGST1
Gene fusions - Rearrangements
Fusion : QuiverMGST1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGST1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGST1
dbVarMGST1
ClinVarMGST1
1000_GenomesMGST1 
Exome Variant ServerMGST1
ExAC (Exome Aggregation Consortium)ENSG00000008394
GNOMAD BrowserENSG00000008394
Varsome BrowserMGST1
Genetic variants : HAPMAP4257
Genomic Variants (DGV)MGST1 [DGVbeta]
DECIPHERMGST1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGST1 
Mutations
ICGC Data PortalMGST1 
TCGA Data PortalMGST1 
Broad Tumor PortalMGST1
OASIS PortalMGST1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGST1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMGST1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MGST1
DgiDB (Drug Gene Interaction Database)MGST1
DoCM (Curated mutations)MGST1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGST1 (select a term)
intoGenMGST1
Cancer3DMGST1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138330   
Orphanet
DisGeNETMGST1
MedgenMGST1
Genetic Testing Registry MGST1
NextProtP10620 [Medical]
TSGene4257
GENETestsMGST1
Target ValidationMGST1
Huge Navigator MGST1 [HugePedia]
snp3D : Map Gene to Disease4257
BioCentury BCIQMGST1
ClinGenMGST1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4257
Chemical/Pharm GKB GenePA30791
Clinical trialMGST1
Miscellaneous
canSAR (ICR)MGST1 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGST1
EVEXMGST1
GoPubMedMGST1
iHOPMGST1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:19:54 CET 2018

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