MGST2 (microsomal glutathione S-transferase 2)

2014-08-01  

Identity

HGNC
LOCATION
4q31.1
LOCUSID
ALIAS
GST2,MGST-II
FUSION GENES

Other Information

Locus ID:

NCBI: 4258
MIM: 601733
HGNC: 7063
Ensembl: ENSG00000085871

Variants:

dbSNP: 4258
ClinVar: 4258
TCGA: ENSG00000085871
COSMIC: MGST2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085871ENST00000265498Q99735
ENSG00000085871ENST00000503816Q99735
ENSG00000085871ENST00000506797Q99735
ENSG00000085871ENST00000616265Q99735

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
234098382013Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.8
260666102015Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.5
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3
167733122006Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.1
167733122006Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.1
164983982006A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris.0

Citation

Dessen P

MGST2 (microsomal glutathione S-transferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54455/mgst2