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MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1)

Identity

Alias_namesNICAL
NEDD9 interacting protein with calponin homology and LIM domains
Alias_symbol (synonym)MICAL
FLJ11937
DKFZp434B1517
FLJ21739
Other aliasMICAL-1
HGNC (Hugo) MICAL1
LocusID (NCBI) 64780
Atlas_Id 55540
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 109444063 and ends at 109455987 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MICAL1 (6q21) / AK9 (6q21)RB1 (13q14.2) / MICAL1 (6q21)TNFRSF14 (1p36.32) / MICAL1 (6q21)
UBR4 (1p36.13) / MICAL1 (6q21)ZNF563 (19p13.2) / MICAL1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MICAL1   20619
Cards
Entrez_Gene (NCBI)MICAL1  64780  microtubule associated monooxygenase, calponin and LIM domain containing 1
AliasesMICAL; MICAL-1; NICAL
GeneCards (Weizmann)MICAL1
Ensembl hg19 (Hinxton)ENSG00000135596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135596 [Gene_View]  ENSG00000135596 [Sequence]  chr6:109444063-109455987 [Contig_View]  MICAL1 [Vega]
ICGC DataPortalENSG00000135596
TCGA cBioPortalMICAL1
AceView (NCBI)MICAL1
Genatlas (Paris)MICAL1
WikiGenes64780
SOURCE (Princeton)MICAL1
Genetics Home Reference (NIH)MICAL1
Genomic and cartography
GoldenPath hg38 (UCSC)MICAL1  -     chr6:109444063-109455987 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MICAL1  -     6q21   [Description]    (hg19-Feb_2009)
EnsemblMICAL1 - 6q21 [CytoView hg19]  MICAL1 - 6q21 [CytoView hg38]
Mapping of homologs : NCBIMICAL1 [Mapview hg19]  MICAL1 [Mapview hg38]
OMIM607129   
Gene and transcription
Genbank (Entrez)AB048948 AK021999 AK024500 AK025392 AK160384
RefSeq transcript (Entrez)NM_001159291 NM_001286613 NM_022765
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MICAL1
Cluster EST : UnigeneHs.33476 [ NCBI ]
CGAP (NCI)Hs.33476
Alternative Splicing GalleryENSG00000135596
Gene ExpressionMICAL1 [ NCBI-GEO ]   MICAL1 [ EBI - ARRAY_EXPRESS ]   MICAL1 [ SEEK ]   MICAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MICAL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64780
GTEX Portal (Tissue expression)MICAL1
Human Protein AtlasENSG00000135596-MICAL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDZ2
Splice isoforms : SwissVarQ8TDZ2
PhosPhoSitePlusQ8TDZ2
Domaine pattern : Prosite (Expaxy)BMERB (PS51848)    CH (PS50021)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)CH-domain    CH_dom_sf    DUF3585    FAD-bd    FAD/NAD-bd_sf    MICAL1    Znf_LIM   
Domain families : Pfam (Sanger)CH (PF00307)    DUF3585 (PF12130)    FAD_binding_3 (PF01494)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00307    pfam12130    pfam01494    pfam00412   
Domain families : Smart (EMBL)CH (SM00033)  LIM (SM00132)  
Conserved Domain (NCBI)MICAL1
DMDM Disease mutations64780
Blocks (Seattle)MICAL1
PDB (SRS)1WYL    2CO8    2DK9    5LE0    5LPN   
PDB (PDBSum)1WYL    2CO8    2DK9    5LE0    5LPN   
PDB (IMB)1WYL    2CO8    2DK9    5LE0    5LPN   
PDB (RSDB)1WYL    2CO8    2DK9    5LE0    5LPN   
Structural Biology KnowledgeBase1WYL    2CO8    2DK9    5LE0    5LPN   
SCOP (Structural Classification of Proteins)1WYL    2CO8    2DK9    5LE0    5LPN   
CATH (Classification of proteins structures)1WYL    2CO8    2DK9    5LE0    5LPN   
SuperfamilyQ8TDZ2
Human Protein Atlas [tissue]ENSG00000135596-MICAL1 [tissue]
Peptide AtlasQ8TDZ2
HPRD06183
IPIIPI01014373   IPI00647681   IPI00386301   IPI00157757   IPI00953144   IPI00441963   IPI00643917   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDZ2
IntAct (EBI)Q8TDZ2
FunCoupENSG00000135596
BioGRIDMICAL1
STRING (EMBL)MICAL1
ZODIACMICAL1
Ontologies - Pathways
QuickGOQ8TDZ2
Ontology : AmiGOnegative regulation of protein phosphorylation  actin binding  monooxygenase activity  protein binding  cytoplasm  cytosol  intermediate filament  cytoskeleton organization  signal transduction  blood coagulation  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  SH3 domain binding  Rab GTPase binding  sulfur oxidation  protein kinase binding  actin filament depolymerization  midbody  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  metal ion binding  oxidation-reduction process  FAD binding  regulation of regulated secretory pathway  hippocampal mossy fiber expansion  
Ontology : EGO-EBInegative regulation of protein phosphorylation  actin binding  monooxygenase activity  protein binding  cytoplasm  cytosol  intermediate filament  cytoskeleton organization  signal transduction  blood coagulation  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  SH3 domain binding  Rab GTPase binding  sulfur oxidation  protein kinase binding  actin filament depolymerization  midbody  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  metal ion binding  oxidation-reduction process  FAD binding  regulation of regulated secretory pathway  hippocampal mossy fiber expansion  
NDEx NetworkMICAL1
Atlas of Cancer Signalling NetworkMICAL1
Wikipedia pathwaysMICAL1
Orthology - Evolution
OrthoDB64780
GeneTree (enSembl)ENSG00000135596
Phylogenetic Trees/Animal Genes : TreeFamMICAL1
HOVERGENQ8TDZ2
HOGENOMQ8TDZ2
Homologs : HomoloGeneMICAL1
Homology/Alignments : Family Browser (UCSC)MICAL1
Gene fusions - Rearrangements
Fusion : QuiverMICAL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMICAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MICAL1
dbVarMICAL1
ClinVarMICAL1
1000_GenomesMICAL1 
Exome Variant ServerMICAL1
ExAC (Exome Aggregation Consortium)ENSG00000135596
GNOMAD BrowserENSG00000135596
Varsome BrowserMICAL1
Genetic variants : HAPMAP64780
Genomic Variants (DGV)MICAL1 [DGVbeta]
DECIPHERMICAL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMICAL1 
Mutations
ICGC Data PortalMICAL1 
TCGA Data PortalMICAL1 
Broad Tumor PortalMICAL1
OASIS PortalMICAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMICAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMICAL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MICAL1
DgiDB (Drug Gene Interaction Database)MICAL1
DoCM (Curated mutations)MICAL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MICAL1 (select a term)
intoGenMICAL1
Cancer3DMICAL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607129   
Orphanet
DisGeNETMICAL1
MedgenMICAL1
Genetic Testing Registry MICAL1
NextProtQ8TDZ2 [Medical]
TSGene64780
GENETestsMICAL1
Target ValidationMICAL1
Huge Navigator MICAL1 [HugePedia]
snp3D : Map Gene to Disease64780
BioCentury BCIQMICAL1
ClinGenMICAL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64780
Chemical/Pharm GKB GenePA134900249
Clinical trialMICAL1
Miscellaneous
canSAR (ICR)MICAL1 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMICAL1
EVEXMICAL1
GoPubMedMICAL1
iHOPMICAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:19:58 CET 2018

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