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MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2)

Identity

Alias_symbol (synonym)KIAA0750
Other aliasMICAL-2
MICAL2PV1
MICAL2PV2
HGNC (Hugo) MICAL2
LocusID (NCBI) 9645
Atlas_Id 46433
Location 11p15.3  [Link to chromosome band 11p15]
Location_base_pair Starts at 12110576 and ends at 12263790 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAH11 (7p15.3) / MICAL2 (11p15.3)MICAL2 (11p15.3) / CIC (19q13.2)MICAL2 (11p15.3) / LPO (17q22)
MICAL2 (11p15.3) / PARVA (11p15.3)MICAL2 (11p15.3) / PSMC5 (17q23.3)MICAL2 (11p15.3) / VMP1 (17q23.1)
NOL3 (16q22.1) / MICAL2 (11p15.3)PARVA (11p15.3) / MICAL2 (11p15.3)TEAD1 (11p15.3) / MICAL2 (11p15.3)
TEAD1 11p15.3 / MICAL2 11p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MICAL2   24693
Cards
Entrez_Gene (NCBI)MICAL2  9645  microtubule associated monooxygenase, calponin and LIM domain containing 2
AliasesMICAL-2; MICAL2PV1; MICAL2PV2
GeneCards (Weizmann)MICAL2
Ensembl hg19 (Hinxton)ENSG00000133816 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133816 [Gene_View]  chr11:12110576-12263790 [Contig_View]  MICAL2 [Vega]
ICGC DataPortalENSG00000133816
TCGA cBioPortalMICAL2
AceView (NCBI)MICAL2
Genatlas (Paris)MICAL2
WikiGenes9645
SOURCE (Princeton)MICAL2
Genetics Home Reference (NIH)MICAL2
Genomic and cartography
GoldenPath hg38 (UCSC)MICAL2  -     chr11:12110576-12263790 +  11p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MICAL2  -     11p15.3   [Description]    (hg19-Feb_2009)
EnsemblMICAL2 - 11p15.3 [CytoView hg19]  MICAL2 - 11p15.3 [CytoView hg38]
Mapping of homologs : NCBIMICAL2 [Mapview hg19]  MICAL2 [Mapview hg38]
OMIM608881   
Gene and transcription
Genbank (Entrez)AB018293 AB110785 AB110786 AF052170 AK025186
RefSeq transcript (Entrez)NM_001282663 NM_001282664 NM_001282665 NM_001282666 NM_001282667 NM_001282668 NM_001346292 NM_001346293 NM_001346294 NM_001346295 NM_001346296 NM_001346297 NM_001346298 NM_001346299 NM_014632
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MICAL2
Cluster EST : UnigeneHs.501928 [ NCBI ]
CGAP (NCI)Hs.501928
Alternative Splicing GalleryENSG00000133816
Gene ExpressionMICAL2 [ NCBI-GEO ]   MICAL2 [ EBI - ARRAY_EXPRESS ]   MICAL2 [ SEEK ]   MICAL2 [ MEM ]
Gene Expression Viewer (FireBrowse)MICAL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9645
GTEX Portal (Tissue expression)MICAL2
Human Protein AtlasENSG00000133816-MICAL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94851   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94851  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94851
Splice isoforms : SwissVarO94851
PhosPhoSitePlusO94851
Domaine pattern : Prosite (Expaxy)CH (PS50021)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)CH-domain    FAD-bd    FAD/NAD-binding_dom    MICAL2    Znf_LIM   
Domain families : Pfam (Sanger)CH (PF00307)    FAD_binding_3 (PF01494)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00307    pfam01494    pfam00412   
Domain families : Smart (EMBL)CH (SM00033)  LIM (SM00132)  
Conserved Domain (NCBI)MICAL2
DMDM Disease mutations9645
Blocks (Seattle)MICAL2
PDB (SRS)2E9K   
PDB (PDBSum)2E9K   
PDB (IMB)2E9K   
PDB (RSDB)2E9K   
Structural Biology KnowledgeBase2E9K   
SCOP (Structural Classification of Proteins)2E9K   
CATH (Classification of proteins structures)2E9K   
SuperfamilyO94851
Human Protein Atlas [tissue]ENSG00000133816-MICAL2 [tissue]
Peptide AtlasO94851
HPRD10085
IPIIPI00183018   IPI00909269   IPI00414591   IPI00552407   IPI01009917   IPI00922235   IPI00980049   IPI00977896   IPI00977197   IPI00976400   IPI00979386   IPI00982673   
Protein Interaction databases
DIP (DOE-UCLA)O94851
IntAct (EBI)O94851
FunCoupENSG00000133816
BioGRIDMICAL2
STRING (EMBL)MICAL2
ZODIACMICAL2
Ontologies - Pathways
QuickGOO94851
Ontology : AmiGOheart looping  actin binding  actin binding  nucleus  cytoskeleton organization  heart development  zinc ion binding  positive regulation of transcription via serum response element binding  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  sulfur oxidation  sulfur oxidation  actin filament depolymerization  actin filament depolymerization  NADPH:sulfur oxidoreductase activity  oxidation-reduction process  FAD binding  
Ontology : EGO-EBIheart looping  actin binding  actin binding  nucleus  cytoskeleton organization  heart development  zinc ion binding  positive regulation of transcription via serum response element binding  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  sulfur oxidation  sulfur oxidation  actin filament depolymerization  actin filament depolymerization  NADPH:sulfur oxidoreductase activity  oxidation-reduction process  FAD binding  
NDEx NetworkMICAL2
Atlas of Cancer Signalling NetworkMICAL2
Wikipedia pathwaysMICAL2
Orthology - Evolution
OrthoDB9645
GeneTree (enSembl)ENSG00000133816
Phylogenetic Trees/Animal Genes : TreeFamMICAL2
HOVERGENO94851
HOGENOMO94851
Homologs : HomoloGeneMICAL2
Homology/Alignments : Family Browser (UCSC)MICAL2
Gene fusions - Rearrangements
Fusion : MitelmanTEAD1/MICAL2 [11p15.3/11p15.3]  [t(11;11)(p15;p15)]  
Fusion: TCGA_MDACCTEAD1 11p15.3 MICAL2 11p15.3 PRAD
Tumor Fusion PortalMICAL2
Fusion Cancer (Beijing)MICAL2 [11p15.3]  -  PSMC5 [17q23.3]  [FUSC004306]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMICAL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MICAL2
dbVarMICAL2
ClinVarMICAL2
1000_GenomesMICAL2 
Exome Variant ServerMICAL2
ExAC (Exome Aggregation Consortium)ENSG00000133816
GNOMAD BrowserENSG00000133816
Genetic variants : HAPMAP9645
Genomic Variants (DGV)MICAL2 [DGVbeta]
DECIPHERMICAL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMICAL2 
Mutations
ICGC Data PortalMICAL2 
TCGA Data PortalMICAL2 
Broad Tumor PortalMICAL2
OASIS PortalMICAL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMICAL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMICAL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MICAL2
DgiDB (Drug Gene Interaction Database)MICAL2
DoCM (Curated mutations)MICAL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MICAL2 (select a term)
intoGenMICAL2
Cancer3DMICAL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608881   
Orphanet
DisGeNETMICAL2
MedgenMICAL2
Genetic Testing Registry MICAL2
NextProtO94851 [Medical]
TSGene9645
GENETestsMICAL2
Target ValidationMICAL2
Huge Navigator MICAL2 [HugePedia]
snp3D : Map Gene to Disease9645
BioCentury BCIQMICAL2
ClinGenMICAL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9645
Chemical/Pharm GKB GenePA142671453
Clinical trialMICAL2
Miscellaneous
canSAR (ICR)MICAL2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMICAL2
EVEXMICAL2
GoPubMedMICAL2
iHOPMICAL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:22:22 CET 2017

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