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MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3)

Identity

Alias_symbol (synonym)KIAA0819
Other aliasMICAL-3
HGNC (Hugo) MICAL3
LocusID (NCBI) 57553
Atlas_Id 56227
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 17834336 and ends at 17906886 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERBB3 (12q13.2) / MICAL3 (22q11.21)HIST2H2BF (1q21.2) / MICAL3 (22q11.21)MICAL3 (22q11.21) / MICAL3 (22q11.21)
MICAL3 (22q11.21) / PPT1 (1p34.2)MICAL3 (22q11.21) / SLC1A3 (5p13.2)MICAL3 (22q11.21) / SLC25A18 (22q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MICAL3   24694
Cards
Entrez_Gene (NCBI)MICAL3  57553  microtubule associated monooxygenase, calponin and LIM domain containing 3
AliasesMICAL-3
GeneCards (Weizmann)MICAL3
Ensembl hg19 (Hinxton)ENSG00000243156 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243156 [Gene_View]  chr22:17834336-17906886 [Contig_View]  MICAL3 [Vega]
ICGC DataPortalENSG00000243156
TCGA cBioPortalMICAL3
AceView (NCBI)MICAL3
Genatlas (Paris)MICAL3
WikiGenes57553
SOURCE (Princeton)MICAL3
Genetics Home Reference (NIH)MICAL3
Genomic and cartography
GoldenPath hg38 (UCSC)MICAL3  -     chr22:17834336-17906886 -  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MICAL3  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblMICAL3 - 22q11.21 [CytoView hg19]  MICAL3 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIMICAL3 [Mapview hg19]  MICAL3 [Mapview hg38]
OMIM608882   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001122731 NM_001136004 NM_015241 NM_020793
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MICAL3
Cluster EST : UnigeneHs.528024 [ NCBI ]
CGAP (NCI)Hs.528024
Alternative Splicing GalleryENSG00000243156
Gene ExpressionMICAL3 [ NCBI-GEO ]   MICAL3 [ EBI - ARRAY_EXPRESS ]   MICAL3 [ SEEK ]   MICAL3 [ MEM ]
Gene Expression Viewer (FireBrowse)MICAL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57553
GTEX Portal (Tissue expression)MICAL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7RTP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7RTP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7RTP6
Splice isoforms : SwissVarQ7RTP6
Catalytic activity : Enzyme1.14.13.225 [ Enzyme-Expasy ]   1.14.13.2251.14.13.225 [ IntEnz-EBI ]   1.14.13.225 [ BRENDA ]   1.14.13.225 [ KEGG ]   
PhosPhoSitePlusQ7RTP6
Domaine pattern : Prosite (Expaxy)CH (PS50021)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)CH-domain    DUF3585    FAD-bd    FAD/NAD-binding_dom    MICAL3    Znf_LIM   
Domain families : Pfam (Sanger)CH (PF00307)    DUF3585 (PF12130)    FAD_binding_3 (PF01494)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00307    pfam12130    pfam01494    pfam00412   
Domain families : Smart (EMBL)CH (SM00033)  LIM (SM00132)  
Conserved Domain (NCBI)MICAL3
DMDM Disease mutations57553
Blocks (Seattle)MICAL3
PDB (SRS)2D88    5SZG   
PDB (PDBSum)2D88    5SZG   
PDB (IMB)2D88    5SZG   
PDB (RSDB)2D88    5SZG   
Structural Biology KnowledgeBase2D88    5SZG   
SCOP (Structural Classification of Proteins)2D88    5SZG   
CATH (Classification of proteins structures)2D88    5SZG   
SuperfamilyQ7RTP6
Human Protein AtlasENSG00000243156
Peptide AtlasQ7RTP6
IPIIPI00177937   IPI00480203   IPI00969176   IPI00741791   IPI00896430   IPI00979242   IPI01010424   
Protein Interaction databases
DIP (DOE-UCLA)Q7RTP6
IntAct (EBI)Q7RTP6
FunCoupENSG00000243156
BioGRIDMICAL3
STRING (EMBL)MICAL3
ZODIACMICAL3
Ontologies - Pathways
QuickGOQ7RTP6
Ontology : AmiGOactin binding  actin binding  nucleus  nucleoplasm  spindle  cytosol  plasma membrane  cell cortex  exocytosis  cytoskeleton organization  cell cycle  zinc ion binding  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  Rab GTPase binding  actin filament depolymerization  actin filament depolymerization  midbody  cell projection  cell division  oxidation-reduction process  FAD binding  
Ontology : EGO-EBIactin binding  actin binding  nucleus  nucleoplasm  spindle  cytosol  plasma membrane  cell cortex  exocytosis  cytoskeleton organization  cell cycle  zinc ion binding  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  Rab GTPase binding  actin filament depolymerization  actin filament depolymerization  midbody  cell projection  cell division  oxidation-reduction process  FAD binding  
NDEx NetworkMICAL3
Atlas of Cancer Signalling NetworkMICAL3
Wikipedia pathwaysMICAL3
Orthology - Evolution
OrthoDB57553
GeneTree (enSembl)ENSG00000243156
Phylogenetic Trees/Animal Genes : TreeFamMICAL3
HOVERGENQ7RTP6
HOGENOMQ7RTP6
Homologs : HomoloGeneMICAL3
Homology/Alignments : Family Browser (UCSC)MICAL3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMICAL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MICAL3
dbVarMICAL3
ClinVarMICAL3
1000_GenomesMICAL3 
Exome Variant ServerMICAL3
ExAC (Exome Aggregation Consortium)MICAL3 (select the gene name)
Genetic variants : HAPMAP57553
Genomic Variants (DGV)MICAL3 [DGVbeta]
DECIPHERMICAL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMICAL3 
Mutations
ICGC Data PortalMICAL3 
TCGA Data PortalMICAL3 
Broad Tumor PortalMICAL3
OASIS PortalMICAL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMICAL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMICAL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MICAL3
DgiDB (Drug Gene Interaction Database)MICAL3
DoCM (Curated mutations)MICAL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MICAL3 (select a term)
intoGenMICAL3
Cancer3DMICAL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608882   
Orphanet
MedgenMICAL3
Genetic Testing Registry MICAL3
NextProtQ7RTP6 [Medical]
TSGene57553
GENETestsMICAL3
Target ValidationMICAL3
Huge Navigator MICAL3 [HugePedia]
snp3D : Map Gene to Disease57553
BioCentury BCIQMICAL3
ClinGenMICAL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57553
Chemical/Pharm GKB GenePA142671454
Clinical trialMICAL3
Miscellaneous
canSAR (ICR)MICAL3 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMICAL3
EVEXMICAL3
GoPubMedMICAL3
iHOPMICAL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:43:00 CEST 2017

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