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MICB (MHC class I polypeptide-related sequence B)

Identity

Alias_symbol (synonym)PERB11.2
Other alias
HGNC (Hugo) MICB
LocusID (NCBI) 4277
Atlas_Id 45710
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31498050 and ends at 31511124 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL11B (14q32.2) / MICB (6p21.33)CCNK (14q32.2) / MICB (6p21.33)MICB (6p21.33) / BCL11B (14q32.2)
MICB (6p21.33) / HLA-H (6p22.1)MICB (6p21.33) / MICB (6p21.33)MICB (6p21.33) / NFE2L1 (17q21.32)
MICB (6p21.33) / PCDH11Y (Yp11.2)MICB (6p21.33) / RAB29 (1q32.1)MICB (6p21.33) / RPL3 (22q13.1)
MICB (6p21.33) / SHANK3 (22q13.33)MICB (6p21.33) / TXNRD3 (3q21.3)MICB (6p21.33) / UBXN7 (3q29)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MICB   7091
Cards
Entrez_Gene (NCBI)MICB  4277  MHC class I polypeptide-related sequence B
AliasesPERB11.2
GeneCards (Weizmann)MICB
Ensembl hg19 (Hinxton)ENSG00000204516 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204516 [Gene_View]  ENSG00000204516 [Sequence]  chr6:31498050-31511124 [Contig_View]  MICB [Vega]
ICGC DataPortalENSG00000204516
TCGA cBioPortalMICB
AceView (NCBI)MICB
Genatlas (Paris)MICB
WikiGenes4277
SOURCE (Princeton)MICB
Genetics Home Reference (NIH)MICB
Genomic and cartography
GoldenPath hg38 (UCSC)MICB  -     chr6:31498050-31511124 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MICB  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblMICB - 6p21.33 [CytoView hg19]  MICB - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIMICB [Mapview hg19]  MICB [Mapview hg38]
OMIM602436   
Gene and transcription
Genbank (Entrez)AF021221 AF021222 AF021223 AF021224 AF021225
RefSeq transcript (Entrez)NM_001289160 NM_001289161 NM_005931
RefSeq genomic (Entrez)NC_000006 NG_021405 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)MICB
Cluster EST : UnigeneHs.731446 [ NCBI ]
CGAP (NCI)Hs.731446
Alternative Splicing GalleryENSG00000204516
Gene ExpressionMICB [ NCBI-GEO ]   MICB [ EBI - ARRAY_EXPRESS ]   MICB [ SEEK ]   MICB [ MEM ]
Gene Expression Viewer (FireBrowse)MICB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4277
GTEX Portal (Tissue expression)MICB
Human Protein AtlasENSG00000204516-MICB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ29980   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ29980  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ29980
Splice isoforms : SwissVarQ29980
PhosPhoSitePlusQ29980
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_C1-set    MHC_I-like_Ag-recog    MHC_I-like_Ag-recog_sf    MHC_I/II-like_Ag-recog   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_I (PF00129)   
Domain families : Pfam (NCBI)pfam07654    pfam00129   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)MICB
DMDM Disease mutations4277
Blocks (Seattle)MICB
PDB (SRS)1JE6    2WY3   
PDB (PDBSum)1JE6    2WY3   
PDB (IMB)1JE6    2WY3   
PDB (RSDB)1JE6    2WY3   
Structural Biology KnowledgeBase1JE6    2WY3   
SCOP (Structural Classification of Proteins)1JE6    2WY3   
CATH (Classification of proteins structures)1JE6    2WY3   
SuperfamilyQ29980
Human Protein Atlas [tissue]ENSG00000204516-MICB [tissue]
Peptide AtlasQ29980
HPRD03894
IPIIPI00646545   IPI00895817   IPI01020877   IPI01026543   IPI01021764   IPI00942385   IPI00647961   IPI00793961   IPI00647042   IPI00893359   IPI00892606   IPI00894561   IPI00893236   IPI00893870   
Protein Interaction databases
DIP (DOE-UCLA)Q29980
IntAct (EBI)Q29980
FunCoupENSG00000204516
BioGRIDMICB
STRING (EMBL)MICB
ZODIACMICB
Ontologies - Pathways
QuickGOQ29980
Ontology : AmiGOT cell mediated cytotoxicity  immune response-activating cell surface receptor signaling pathway  plasma membrane  plasma membrane  immune response  response to oxidative stress  response to heat  cell surface  integral component of membrane  viral process  cytolysis  natural killer cell activation  response to retinoic acid  natural killer cell mediated cytotoxicity  susceptibility to natural killer cell mediated cytotoxicity  gamma-delta T cell activation  natural killer cell lectin-like receptor binding  natural killer cell lectin-like receptor binding  negative regulation of defense response to virus by host  regulation of immune response  
Ontology : EGO-EBIT cell mediated cytotoxicity  immune response-activating cell surface receptor signaling pathway  plasma membrane  plasma membrane  immune response  response to oxidative stress  response to heat  cell surface  integral component of membrane  viral process  cytolysis  natural killer cell activation  response to retinoic acid  natural killer cell mediated cytotoxicity  susceptibility to natural killer cell mediated cytotoxicity  gamma-delta T cell activation  natural killer cell lectin-like receptor binding  natural killer cell lectin-like receptor binding  negative regulation of defense response to virus by host  regulation of immune response  
Pathways : KEGGNatural killer cell mediated cytotoxicity   
NDEx NetworkMICB
Atlas of Cancer Signalling NetworkMICB
Wikipedia pathwaysMICB
Orthology - Evolution
OrthoDB4277
GeneTree (enSembl)ENSG00000204516
Phylogenetic Trees/Animal Genes : TreeFamMICB
HOVERGENQ29980
HOGENOMQ29980
Homologs : HomoloGeneMICB
Homology/Alignments : Family Browser (UCSC)MICB
Gene fusions - Rearrangements
Fusion : QuiverMICB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMICB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MICB
dbVarMICB
ClinVarMICB
1000_GenomesMICB 
Exome Variant ServerMICB
ExAC (Exome Aggregation Consortium)ENSG00000204516
GNOMAD BrowserENSG00000204516
Varsome BrowserMICB
Genetic variants : HAPMAP4277
Genomic Variants (DGV)MICB [DGVbeta]
DECIPHERMICB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMICB 
Mutations
ICGC Data PortalMICB 
TCGA Data PortalMICB 
Broad Tumor PortalMICB
OASIS PortalMICB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMICB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMICB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MICB
DgiDB (Drug Gene Interaction Database)MICB
DoCM (Curated mutations)MICB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MICB (select a term)
intoGenMICB
Cancer3DMICB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602436   
Orphanet
DisGeNETMICB
MedgenMICB
Genetic Testing Registry MICB
NextProtQ29980 [Medical]
TSGene4277
GENETestsMICB
Target ValidationMICB
Huge Navigator MICB [HugePedia]
snp3D : Map Gene to Disease4277
BioCentury BCIQMICB
ClinGenMICB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4277
Chemical/Pharm GKB GenePA30812
Clinical trialMICB
Miscellaneous
canSAR (ICR)MICB (select the gene name)
Probes
Litterature
PubMed166 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMICB
EVEXMICB
GoPubMedMICB
iHOPMICB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:20:00 CET 2018

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