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MICU2 (mitochondrial calcium uptake 2)

Identity

Alias_namesEFHA1
EF hand domain family A1
EF-hand domain family, member A1
Other alias1110008L20Rik
HGNC (Hugo) MICU2
LocusID (NCBI) 221154
Atlas_Id 68978
Location 13q12.11  [Link to chromosome band 13q12]
Location_base_pair Starts at 21492689 and ends at 21604216 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IKZF2 (2q34) / MICU2 (13q12.11)MAPK14 (6p21.31) / MICU2 (13q12.11)MICU2 (13q12.11) / ATP8A2 (13q12.13)
WEE1 (11p15.4) / MICU2 (13q12.11)ZDHHC20 (13q12.11) / MICU2 (13q12.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MICU2   31830
Cards
Entrez_Gene (NCBI)MICU2  221154  mitochondrial calcium uptake 2
Aliases1110008L20Rik; EFHA1
GeneCards (Weizmann)MICU2
Ensembl hg19 (Hinxton)ENSG00000165487 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165487 [Gene_View]  chr13:21492689-21604216 [Contig_View]  MICU2 [Vega]
ICGC DataPortalENSG00000165487
TCGA cBioPortalMICU2
AceView (NCBI)MICU2
Genatlas (Paris)MICU2
WikiGenes221154
SOURCE (Princeton)MICU2
Genetics Home Reference (NIH)MICU2
Genomic and cartography
GoldenPath hg38 (UCSC)MICU2  -     chr13:21492689-21604216 -  13q12.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MICU2  -     13q12.11   [Description]    (hg19-Feb_2009)
EnsemblMICU2 - 13q12.11 [CytoView hg19]  MICU2 - 13q12.11 [CytoView hg38]
Mapping of homologs : NCBIMICU2 [Mapview hg19]  MICU2 [Mapview hg38]
OMIM610632   
Gene and transcription
Genbank (Entrez)AK057745 AK091907 BC031089 BC034965 BQ438851
RefSeq transcript (Entrez)NM_152726
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MICU2
Cluster EST : UnigeneHs.412103 [ NCBI ]
CGAP (NCI)Hs.412103
Alternative Splicing GalleryENSG00000165487
Gene ExpressionMICU2 [ NCBI-GEO ]   MICU2 [ EBI - ARRAY_EXPRESS ]   MICU2 [ SEEK ]   MICU2 [ MEM ]
Gene Expression Viewer (FireBrowse)MICU2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221154
GTEX Portal (Tissue expression)MICU2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYU8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYU8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYU8
Splice isoforms : SwissVarQ8IYU8
PhosPhoSitePlusQ8IYU8
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_8 (PF13833)   
Domain families : Pfam (NCBI)pfam13833   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)MICU2
DMDM Disease mutations221154
Blocks (Seattle)MICU2
SuperfamilyQ8IYU8
Human Protein AtlasENSG00000165487
Peptide AtlasQ8IYU8
HPRD16852
IPIIPI00640276   IPI00983825   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYU8
IntAct (EBI)Q8IYU8
FunCoupENSG00000165487
BioGRIDMICU2
STRING (EMBL)MICU2
ZODIACMICU2
Ontologies - Pathways
QuickGOQ8IYU8
Ontology : AmiGOcalcium ion binding  protein binding  nucleus  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial calcium ion transmembrane transport  calcium channel complex  mitochondrial calcium uptake  protein heterodimerization activity  mitochondrial calcium ion homeostasis  positive regulation of mitochondrial calcium ion concentration  negative regulation of mitochondrial calcium ion concentration  uniplex complex  
Ontology : EGO-EBIcalcium ion binding  protein binding  nucleus  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial calcium ion transmembrane transport  calcium channel complex  mitochondrial calcium uptake  protein heterodimerization activity  mitochondrial calcium ion homeostasis  positive regulation of mitochondrial calcium ion concentration  negative regulation of mitochondrial calcium ion concentration  uniplex complex  
NDEx NetworkMICU2
Atlas of Cancer Signalling NetworkMICU2
Wikipedia pathwaysMICU2
Orthology - Evolution
OrthoDB221154
GeneTree (enSembl)ENSG00000165487
Phylogenetic Trees/Animal Genes : TreeFamMICU2
HOVERGENQ8IYU8
HOGENOMQ8IYU8
Homologs : HomoloGeneMICU2
Homology/Alignments : Family Browser (UCSC)MICU2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMICU2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MICU2
dbVarMICU2
ClinVarMICU2
1000_GenomesMICU2 
Exome Variant ServerMICU2
ExAC (Exome Aggregation Consortium)MICU2 (select the gene name)
Genetic variants : HAPMAP221154
Genomic Variants (DGV)MICU2 [DGVbeta]
DECIPHERMICU2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMICU2 
Mutations
ICGC Data PortalMICU2 
TCGA Data PortalMICU2 
Broad Tumor PortalMICU2
OASIS PortalMICU2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMICU2
BioMutasearch MICU2
DgiDB (Drug Gene Interaction Database)MICU2
DoCM (Curated mutations)MICU2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MICU2 (select a term)
intoGenMICU2
Cancer3DMICU2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610632   
Orphanet
MedgenMICU2
Genetic Testing Registry MICU2
NextProtQ8IYU8 [Medical]
TSGene221154
GENETestsMICU2
Target ValidationMICU2
Huge Navigator MICU2 [HugePedia]
snp3D : Map Gene to Disease221154
BioCentury BCIQMICU2
ClinGenMICU2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD221154
Chemical/Pharm GKB GenePA134891566
Clinical trialMICU2
Miscellaneous
canSAR (ICR)MICU2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMICU2
EVEXMICU2
GoPubMedMICU2
iHOPMICU2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:26:09 CEST 2017

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