Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MID1 (midline 1)

Identity

Alias_symbol (synonym)OS
FXY
TRIM18
RNF59
Other aliasBBBG1
GBBB1
MIDIN
OGS1
OSX
XPRF
ZNFXY
HGNC (Hugo) MID1
LocusID (NCBI) 4281
Atlas_Id 54457
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 10445310 and ends at 10620634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EDA (Xq13.1) / MID1 (Xp22.2)LOC284395 (19q12) / MID1 (Xp22.2)MID1 (Xp22.2) / ARHGAP6 (Xp22.2)
MID1 (Xp22.2) / S100A2 (1q21.3)MID1 (Xp22.2) / YIPF6 (Xq12)MID1 Xp22.2 / ARHGAP6 Xp22.2
MID1 Xp22.2 / S100A2 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MID1   7095
Cards
Entrez_Gene (NCBI)MID1  4281  midline 1
AliasesBBBG1; FXY; GBBB1; MIDIN; 
OGS1; OS; OSX; RNF59; TRIM18; XPRF; ZNFXY
GeneCards (Weizmann)MID1
Ensembl hg19 (Hinxton)ENSG00000101871 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101871 [Gene_View]  chrX:10445310-10620634 [Contig_View]  MID1 [Vega]
ICGC DataPortalENSG00000101871
TCGA cBioPortalMID1
AceView (NCBI)MID1
Genatlas (Paris)MID1
WikiGenes4281
SOURCE (Princeton)MID1
Genetics Home Reference (NIH)MID1
Genomic and cartography
GoldenPath hg38 (UCSC)MID1  -     chrX:10445310-10620634 -  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MID1  -     Xp22.2   [Description]    (hg19-Feb_2009)
EnsemblMID1 - Xp22.2 [CytoView hg19]  MID1 - Xp22.2 [CytoView hg38]
Mapping of homologs : NCBIMID1 [Mapview hg19]  MID1 [Mapview hg38]
OMIM189960   300000   300552   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_000381 NM_001098624 NM_001193277 NM_001193278 NM_001193279 NM_001193280 NM_001193281 NM_001347733 NM_033289 NM_033290 NM_033291
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MID1
Cluster EST : UnigeneHs.738954 [ NCBI ]
CGAP (NCI)Hs.738954
Alternative Splicing GalleryENSG00000101871
Gene ExpressionMID1 [ NCBI-GEO ]   MID1 [ EBI - ARRAY_EXPRESS ]   MID1 [ SEEK ]   MID1 [ MEM ]
Gene Expression Viewer (FireBrowse)MID1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4281
GTEX Portal (Tissue expression)MID1
Human Protein AtlasENSG00000101871-MID1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15344
Splice isoforms : SwissVarO15344
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusO15344
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    COS (PS51262)    FN3 (PS50853)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Bbox_C    Butyrophylin    ConA-like_dom    COS_domain    FN3_dom    Ig-like_fold    MID1    PRY    SPRY_dom    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)fn3 (PF00041)    PRY (PF13765)    SPRY (PF00622)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00041    pfam13765    pfam00622    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBC (SM00502)  BBOX (SM00336)  FN3 (SM00060)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)MID1
DMDM Disease mutations4281
Blocks (Seattle)MID1
PDB (SRS)2DQ5    2FFW    2JUN    5IM8   
PDB (PDBSum)2DQ5    2FFW    2JUN    5IM8   
PDB (IMB)2DQ5    2FFW    2JUN    5IM8   
PDB (RSDB)2DQ5    2FFW    2JUN    5IM8   
Structural Biology KnowledgeBase2DQ5    2FFW    2JUN    5IM8   
SCOP (Structural Classification of Proteins)2DQ5    2FFW    2JUN    5IM8   
CATH (Classification of proteins structures)2DQ5    2FFW    2JUN    5IM8   
SuperfamilyO15344
Human Protein Atlas [tissue]ENSG00000101871-MID1 [tissue]
Peptide AtlasO15344
HPRD02047
IPIIPI00029324   IPI00219026   IPI00976371   IPI00646829   IPI00977503   IPI00975687   IPI00908484   IPI00977866   IPI00647754   
Protein Interaction databases
DIP (DOE-UCLA)O15344
IntAct (EBI)O15344
FunCoupENSG00000101871
BioGRIDMID1
STRING (EMBL)MID1
ZODIACMID1
Ontologies - Pathways
QuickGOO15344
Ontology : AmiGOmicrotubule cytoskeleton organization  protein binding  spindle  cytosol  microtubule  microtubule associated complex  cytoplasmic microtubule  negative regulation of microtubule depolymerization  pattern specification process  microtubule binding  zinc ion binding  transferase activity  ubiquitin protein ligase binding  positive regulation of stress-activated MAPK cascade  protein localization to microtubule  identical protein binding  protein homodimerization activity  protein heterodimerization activity  phosphoprotein binding  interferon-gamma-mediated signaling pathway  
Ontology : EGO-EBImicrotubule cytoskeleton organization  protein binding  spindle  cytosol  microtubule  microtubule associated complex  cytoplasmic microtubule  negative regulation of microtubule depolymerization  pattern specification process  microtubule binding  zinc ion binding  transferase activity  ubiquitin protein ligase binding  positive regulation of stress-activated MAPK cascade  protein localization to microtubule  identical protein binding  protein homodimerization activity  protein heterodimerization activity  phosphoprotein binding  interferon-gamma-mediated signaling pathway  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkMID1
Atlas of Cancer Signalling NetworkMID1
Wikipedia pathwaysMID1
Orthology - Evolution
OrthoDB4281
GeneTree (enSembl)ENSG00000101871
Phylogenetic Trees/Animal Genes : TreeFamMID1
HOVERGENO15344
HOGENOMO15344
Homologs : HomoloGeneMID1
Homology/Alignments : Family Browser (UCSC)MID1
Gene fusions - Rearrangements
Fusion : MitelmanEDA/MID1 [Xq13.1/Xp22.2]  [t(X;X)(p22;q13)]  
Fusion : MitelmanMID1/ARHGAP6 [Xp22.2/Xp22.2]  [t(X;X)(p22;p22)]  
Fusion : MitelmanMID1/S100A2 [Xp22.2/1q21.3]  [t(X;1)(p22;q21)]  
Fusion: TCGA_MDACCMID1 Xp22.2 ARHGAP6 Xp22.2 BRCA
Fusion: TCGA_MDACCMID1 Xp22.2 S100A2 1q21.3 LUAD
Tumor Fusion PortalMID1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMID1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MID1
dbVarMID1
ClinVarMID1
1000_GenomesMID1 
Exome Variant ServerMID1
ExAC (Exome Aggregation Consortium)ENSG00000101871
GNOMAD BrowserENSG00000101871
Genetic variants : HAPMAP4281
Genomic Variants (DGV)MID1 [DGVbeta]
DECIPHERMID1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMID1 
Mutations
ICGC Data PortalMID1 
TCGA Data PortalMID1 
Broad Tumor PortalMID1
OASIS PortalMID1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMID1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMID1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch MID1
DgiDB (Drug Gene Interaction Database)MID1
DoCM (Curated mutations)MID1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MID1 (select a term)
intoGenMID1
Cancer3DMID1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189960    300000    300552   
Orphanet21238   
DisGeNETMID1
MedgenMID1
Genetic Testing Registry MID1
NextProtO15344 [Medical]
TSGene4281
GENETestsMID1
Target ValidationMID1
Huge Navigator MID1 [HugePedia]
snp3D : Map Gene to Disease4281
BioCentury BCIQMID1
ClinGenMID1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4281
Chemical/Pharm GKB GenePA30816
Clinical trialMID1
Miscellaneous
canSAR (ICR)MID1 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMID1
EVEXMID1
GoPubMedMID1
iHOPMID1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:22:24 CET 2017

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