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MID2 (midline 2)

Identity

Other aliasFXY2
MRX101
RNF60
TRIM1
HGNC (Hugo) MID2
LocusID (NCBI) 11043
Atlas_Id 56701
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 107825854 and ends at 107931637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP29 (1p22.1) / MID2 (Xq22.3)C2CD2 (21q22.3) / MID2 (Xq22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MID2   7096
Cards
Entrez_Gene (NCBI)MID2  11043  midline 2
AliasesFXY2; MRX101; RNF60; TRIM1
GeneCards (Weizmann)MID2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chrX:107825854-107931637 [Contig_View]  MID2 [Vega]
TCGA cBioPortalMID2
AceView (NCBI)MID2
Genatlas (Paris)MID2
WikiGenes11043
SOURCE (Princeton)MID2
Genetics Home Reference (NIH)MID2
Genomic and cartography
GoldenPath hg38 (UCSC)MID2  -     chrX:107825854-107931637 +  Xq22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MID2  -     Xq22.3   [Description]    (hg19-Feb_2009)
EnsemblMID2 - Xq22.3 [CytoView hg19]  MID2 - Xq22.3 [CytoView hg38]
Mapping of homologs : NCBIMID2 [Mapview hg19]  MID2 [Mapview hg38]
OMIM300204   300928   
Gene and transcription
Genbank (Entrez)AF196481 AK095034 AK123807 AY625004 BC017707
RefSeq transcript (Entrez)NM_012216 NM_052817
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MID2
Cluster EST : UnigeneHs.12256 [ NCBI ]
CGAP (NCI)Hs.12256
Gene ExpressionMID2 [ NCBI-GEO ]   MID2 [ EBI - ARRAY_EXPRESS ]   MID2 [ SEEK ]   MID2 [ MEM ]
Gene Expression Viewer (FireBrowse)MID2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11043
GTEX Portal (Tissue expression)MID2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJV3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJV3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJV3
Splice isoforms : SwissVarQ9UJV3
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ9UJV3
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    COS (PS51262)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Bbox_C    Butyrophylin    ConA-like_dom    COS_domain    FN3_dom    Ig-like_fold    MID2    SPRY_dom    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SPRY (PF00622)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00622    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBC (SM00502)  BBOX (SM00336)  FN3 (SM00060)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)MID2
DMDM Disease mutations11043
Blocks (Seattle)MID2
PDB (SRS)2DJA    2DMK   
PDB (PDBSum)2DJA    2DMK   
PDB (IMB)2DJA    2DMK   
PDB (RSDB)2DJA    2DMK   
Structural Biology KnowledgeBase2DJA    2DMK   
SCOP (Structural Classification of Proteins)2DJA    2DMK   
CATH (Classification of proteins structures)2DJA    2DMK   
SuperfamilyQ9UJV3
Peptide AtlasQ9UJV3
IPIIPI00939148   IPI00943123   IPI00956726   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJV3
IntAct (EBI)Q9UJV3
BioGRIDMID2
STRING (EMBL)MID2
ZODIACMID2
Ontologies - Pathways
QuickGOQ9UJV3
Ontology : AmiGOcytoplasm  microtubule  microtubule  microtubule binding  zinc ion binding  positive regulation of autophagy  protein ubiquitination  transferase activity  negative regulation of viral transcription  protein localization to microtubule  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  negative regulation of viral entry into host cell  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  phosphoprotein binding  extracellular exosome  negative regulation of viral release from host cell  
Ontology : EGO-EBIcytoplasm  microtubule  microtubule  microtubule binding  zinc ion binding  positive regulation of autophagy  protein ubiquitination  transferase activity  negative regulation of viral transcription  protein localization to microtubule  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  negative regulation of viral entry into host cell  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  phosphoprotein binding  extracellular exosome  negative regulation of viral release from host cell  
NDEx NetworkMID2
Atlas of Cancer Signalling NetworkMID2
Wikipedia pathwaysMID2
Orthology - Evolution
OrthoDB11043
Phylogenetic Trees/Animal Genes : TreeFamMID2
HOVERGENQ9UJV3
HOGENOMQ9UJV3
Homologs : HomoloGeneMID2
Homology/Alignments : Family Browser (UCSC)MID2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMID2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MID2
dbVarMID2
ClinVarMID2
1000_GenomesMID2 
Exome Variant ServerMID2
ExAC (Exome Aggregation Consortium)MID2 (select the gene name)
Genetic variants : HAPMAP11043
Genomic Variants (DGV)MID2 [DGVbeta]
DECIPHERMID2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMID2 
Mutations
ICGC Data PortalMID2 
TCGA Data PortalMID2 
Broad Tumor PortalMID2
OASIS PortalMID2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMID2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMID2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MID2
DgiDB (Drug Gene Interaction Database)MID2
DoCM (Curated mutations)MID2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MID2 (select a term)
intoGenMID2
Cancer3DMID2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300204    300928   
Orphanet
MedgenMID2
Genetic Testing Registry MID2
NextProtQ9UJV3 [Medical]
TSGene11043
GENETestsMID2
Target ValidationMID2
Huge Navigator MID2 [HugePedia]
snp3D : Map Gene to Disease11043
BioCentury BCIQMID2
ClinGenMID2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11043
Chemical/Pharm GKB GenePA30817
Clinical trialMID2
Miscellaneous
canSAR (ICR)MID2 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMID2
EVEXMID2
GoPubMedMID2
iHOPMID2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:43:02 CEST 2017

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