Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MIER2 (MIER family member 2)

Identity

Alias_namesKIAA1193
KIAA1193
mesoderm induction early response 1, family member 2
Other aliasMi-er2
HGNC (Hugo) MIER2
LocusID (NCBI) 54531
Atlas_Id 54459
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 305575 and ends at 344841 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MIER2 (19p13.3) / CDK5RAP1 (20q11.21)MIER2 (19p13.3) / NMRK2 (19p13.3)MIER2 (19p13.3) / RSRC2 (12q24.31)
MIER2 19p13.3 / CDK5RAP1 20q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Adenocarcinoma
t(12;19)(q24;p13) MIER2/RSRC2
t(19;20)(p13;q11) MIER2/CDK5RAP1

External links

Nomenclature
HGNC (Hugo)MIER2   29210
Cards
Entrez_Gene (NCBI)MIER2  54531  MIER family member 2
AliasesKIAA1193; Mi-er2
GeneCards (Weizmann)MIER2
Ensembl hg19 (Hinxton)ENSG00000105556 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105556 [Gene_View]  ENSG00000105556 [Sequence]  chr19:305575-344841 [Contig_View]  MIER2 [Vega]
ICGC DataPortalENSG00000105556
TCGA cBioPortalMIER2
AceView (NCBI)MIER2
Genatlas (Paris)MIER2
WikiGenes54531
SOURCE (Princeton)MIER2
Genetics Home Reference (NIH)MIER2
Genomic and cartography
GoldenPath hg38 (UCSC)MIER2  -     chr19:305575-344841 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIER2  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathMIER2 - 19p13.3 [CytoView hg19]  MIER2 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000105556
Mapping of homologs : NCBIMIER2 [Mapview hg19]  MIER2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB033019 BC028203 HY026788
RefSeq transcript (Entrez)NM_001346105 NM_017550
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MIER2
Cluster EST : UnigeneHs.101891 [ NCBI ]
CGAP (NCI)Hs.101891
Alternative Splicing GalleryENSG00000105556
Gene ExpressionMIER2 [ NCBI-GEO ]   MIER2 [ EBI - ARRAY_EXPRESS ]   MIER2 [ SEEK ]   MIER2 [ MEM ]
Gene Expression Viewer (FireBrowse)MIER2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54531
GTEX Portal (Tissue expression)MIER2
Human Protein AtlasENSG00000105556-MIER2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N344
Splice isoforms : SwissVarQ8N344
PhosPhoSitePlusQ8N344
Domaine pattern : Prosite (Expaxy)ELM2 (PS51156)    SANT (PS51293)   
Domains : Interpro (EBI)ELM2_dom    Homeobox-like_sf    SANT/Myb    SANT_dom   
Domain families : Pfam (Sanger)ELM2 (PF01448)   
Domain families : Pfam (NCBI)pfam01448   
Domain families : Smart (EMBL)ELM2 (SM01189)  SANT (SM00717)  
Conserved Domain (NCBI)MIER2
DMDM Disease mutations54531
Blocks (Seattle)MIER2
SuperfamilyQ8N344
Human Protein Atlas [tissue]ENSG00000105556-MIER2 [tissue]
Peptide AtlasQ8N344
HPRD11130
IPIIPI00297301   
Protein Interaction databases
DIP (DOE-UCLA)Q8N344
IntAct (EBI)Q8N344
FunCoupENSG00000105556
BioGRIDMIER2
STRING (EMBL)MIER2
ZODIACMIER2
Ontologies - Pathways
QuickGOQ8N344
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II repressing transcription factor binding  DNA binding  transcription corepressor activity  histone deacetylase activity  nucleus  nucleus  nucleoplasm  cytoplasm  histone deacetylation  histone deacetylation  protein-containing complex  histone deacetylase binding  histone deacetylase binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II repressing transcription factor binding  DNA binding  transcription corepressor activity  histone deacetylase activity  nucleus  nucleus  nucleoplasm  cytoplasm  histone deacetylation  histone deacetylation  protein-containing complex  histone deacetylase binding  histone deacetylase binding  
NDEx NetworkMIER2
Atlas of Cancer Signalling NetworkMIER2
Wikipedia pathwaysMIER2
Orthology - Evolution
OrthoDB54531
GeneTree (enSembl)ENSG00000105556
Phylogenetic Trees/Animal Genes : TreeFamMIER2
HOGENOMQ8N344
Homologs : HomoloGeneMIER2
Homology/Alignments : Family Browser (UCSC)MIER2
Gene fusions - Rearrangements
Fusion : MitelmanMIER2/CDK5RAP1 [19p13.3/20q11.21]  
Fusion : MitelmanMIER2/NMRK2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanMIER2/RSRC2 [19p13.3/12q24.31]  [t(12;19)(q24;p13)]  
Fusion PortalMIER2 19p13.3 CDK5RAP1 20q11.21 BLCA
Fusion : QuiverMIER2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMIER2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MIER2
dbVarMIER2
ClinVarMIER2
1000_GenomesMIER2 
Exome Variant ServerMIER2
ExAC (Exome Aggregation Consortium)ENSG00000105556
GNOMAD BrowserENSG00000105556
Varsome BrowserMIER2
Genetic variants : HAPMAP54531
Genomic Variants (DGV)MIER2 [DGVbeta]
DECIPHERMIER2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMIER2 
Mutations
ICGC Data PortalMIER2 
TCGA Data PortalMIER2 
Broad Tumor PortalMIER2
OASIS PortalMIER2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMIER2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMIER2
Mutations and Diseases : HGMDMIER2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MIER2
DgiDB (Drug Gene Interaction Database)MIER2
DoCM (Curated mutations)MIER2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MIER2 (select a term)
intoGenMIER2
Cancer3DMIER2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETMIER2
MedgenMIER2
Genetic Testing Registry MIER2
NextProtQ8N344 [Medical]
TSGene54531
GENETestsMIER2
Target ValidationMIER2
Huge Navigator MIER2 [HugePedia]
snp3D : Map Gene to Disease54531
BioCentury BCIQMIER2
ClinGenMIER2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54531
Chemical/Pharm GKB GenePA134925804
Clinical trialMIER2
Miscellaneous
canSAR (ICR)MIER2 (select the gene name)
DataMed IndexMIER2
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMIER2
EVEXMIER2
GoPubMedMIER2
iHOPMIER2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:53:31 CET 2019
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