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MINK1 (misshapen like kinase 1)

Identity

Alias (NCBI)B55
MAP4K6
MINK
YSK2
ZC3
HGNC (Hugo) MINK1
HGNC Alias symbB55
MINK
ZC3
MAP4K6
YSK2
HGNC Alias namemisshapen/NIK-related kinase
HGNC Previous namemisshapen-like kinase 1 (zebrafish)
 misshapen-like kinase 1
LocusID (NCBI) 50488
Atlas_Id 68989
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 4833340 and ends at 4898061 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALM1 (14q32.11) / MINK1 (17p13.2)MINK1 (17p13.2) / DAZAP2 (12q13.13)MINK1 (17p13.2) / MINK1 (17p13.2)
MINK1 (17p13.2) / NQO2 (6p25.2)MINK1 (17p13.2) / USO1 (4q21.1)RABEP1 (17p13.2) / MINK1 (17p13.2)
RANBP1 (22q11.21) / MINK1 (17p13.2)RPL5 (1p22.1) / MINK1 (17p13.2)MINK1 USO1
MINK1 NQO2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MINK1   17565
Cards
Entrez_Gene (NCBI)MINK1    misshapen like kinase 1
AliasesB55; MAP4K6; MINK; YSK2; 
ZC3
GeneCards (Weizmann)MINK1
Ensembl hg19 (Hinxton)ENSG00000141503 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141503 [Gene_View]  ENSG00000141503 [Sequence]  chr17:4833340-4898061 [Contig_View]  MINK1 [Vega]
ICGC DataPortalENSG00000141503
TCGA cBioPortalMINK1
AceView (NCBI)MINK1
Genatlas (Paris)MINK1
SOURCE (Princeton)MINK1
Genetics Home Reference (NIH)MINK1
Genomic and cartography
GoldenPath hg38 (UCSC)MINK1  -     chr17:4833340-4898061 +  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MINK1  -     17p13.2   [Description]    (hg19-Feb_2009)
GoldenPathMINK1 - 17p13.2 [CytoView hg19]  MINK1 - 17p13.2 [CytoView hg38]
ImmunoBaseENSG00000141503
Genome Data Viewer NCBIMINK1 [Mapview hg19]  
OMIM609426   
Gene and transcription
Genbank (Entrez)AB035698 AB041926 AB209450 AF218033 AK096610
RefSeq transcript (Entrez)NM_001024937 NM_001321236 NM_015716 NM_153827 NM_170663
Consensus coding sequences : CCDS (NCBI)MINK1
Gene ExpressionMINK1 [ NCBI-GEO ]   MINK1 [ EBI - ARRAY_EXPRESS ]   MINK1 [ SEEK ]   MINK1 [ MEM ]
Gene Expression Viewer (FireBrowse)MINK1 [ Firebrowse - Broad ]
GenevisibleExpression of MINK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50488
GTEX Portal (Tissue expression)MINK1
Human Protein AtlasENSG00000141503-MINK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N4C8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N4C8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N4C8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8N4C8
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MINK1
SuperfamilyQ8N4C8
AlphaFold pdb e-kbQ8N4C8   
Human Protein Atlas [tissue]ENSG00000141503-MINK1 [tissue]
HPRD11366
Protein Interaction databases
DIP (DOE-UCLA)Q8N4C8
IntAct (EBI)Q8N4C8
BioGRIDMINK1
STRING (EMBL)MINK1
ZODIACMINK1
Ontologies - Pathways
QuickGOQ8N4C8
Ontology : AmiGOMAPK cascade  regulation of cell-matrix adhesion  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  protein phosphorylation  protein phosphorylation  protein phosphorylation  JNK cascade  chemical synaptic transmission  multicellular organism development  postsynaptic density  regulation of cell-cell adhesion  microvillus assembly  regulation of cell migration  axon  dendrite  actin cytoskeleton reorganization  actin cytoskeleton reorganization  activation of protein kinase activity  intracellular signal transduction  regulation of MAPK cascade  positive regulation of JNK cascade  positive regulation of JNK cascade  protein autophosphorylation  neuron projection morphogenesis  dendrite morphogenesis  extracellular exosome  protein serine kinase activity  protein threonine kinase activity  positive regulation of p38MAPK cascade  regulation of AMPA receptor activity  
Ontology : EGO-EBIMAPK cascade  regulation of cell-matrix adhesion  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  protein phosphorylation  protein phosphorylation  protein phosphorylation  JNK cascade  chemical synaptic transmission  multicellular organism development  postsynaptic density  regulation of cell-cell adhesion  microvillus assembly  regulation of cell migration  axon  dendrite  actin cytoskeleton reorganization  actin cytoskeleton reorganization  activation of protein kinase activity  intracellular signal transduction  regulation of MAPK cascade  positive regulation of JNK cascade  positive regulation of JNK cascade  protein autophosphorylation  neuron projection morphogenesis  dendrite morphogenesis  extracellular exosome  protein serine kinase activity  protein threonine kinase activity  positive regulation of p38MAPK cascade  regulation of AMPA receptor activity  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMINK1
Atlas of Cancer Signalling NetworkMINK1
Wikipedia pathwaysMINK1
Orthology - Evolution
OrthoDB50488
GeneTree (enSembl)ENSG00000141503
Phylogenetic Trees/Animal Genes : TreeFamMINK1
Homologs : HomoloGeneMINK1
Homology/Alignments : Family Browser (UCSC)MINK1
Gene fusions - Rearrangements
Fusion : QuiverMINK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMINK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MINK1
dbVarMINK1
ClinVarMINK1
MonarchMINK1
1000_GenomesMINK1 
Exome Variant ServerMINK1
GNOMAD BrowserENSG00000141503
Varsome BrowserMINK1
ACMGMINK1 variants
VarityQ8N4C8
Genomic Variants (DGV)MINK1 [DGVbeta]
DECIPHERMINK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMINK1 
Mutations
ICGC Data PortalMINK1 
TCGA Data PortalMINK1 
Broad Tumor PortalMINK1
OASIS PortalMINK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMINK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMINK1
Mutations and Diseases : HGMDMINK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMINK1
DgiDB (Drug Gene Interaction Database)MINK1
DoCM (Curated mutations)MINK1
CIViC (Clinical Interpretations of Variants in Cancer)MINK1
Cancer3DMINK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609426   
Orphanet
DisGeNETMINK1
MedgenMINK1
Genetic Testing Registry MINK1
NextProtQ8N4C8 [Medical]
GENETestsMINK1
Target ValidationMINK1
Huge Navigator MINK1 [HugePedia]
ClinGenMINK1
Clinical trials, drugs, therapy
MyCancerGenomeMINK1
Protein Interactions : CTDMINK1
Pharm GKB GenePA134910641
PharosQ8N4C8
Clinical trialMINK1
Miscellaneous
canSAR (ICR)MINK1
HarmonizomeMINK1
DataMed IndexMINK1
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMINK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:07:24 CEST 2021

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