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MINK1 (misshapen-like kinase 1)

Identity

Alias_namesmisshapen-like kinase 1 (zebrafish)
misshapen-like kinase 1
Alias_symbol (synonym)B55
MINK
ZC3
MAP4K6
YSK2
Other aliashMINK
hMINKbeta
HGNC (Hugo) MINK1
LocusID (NCBI) 50488
Atlas_Id 68989
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 4736635 and ends at 4801356 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CALM1 (14q32.11) / MINK1 (17p13.2)MINK1 (17p13.2) / DAZAP2 (12q13.13)MINK1 (17p13.2) / MINK1 (17p13.2)
MINK1 (17p13.2) / NQO2 (6p25.2)MINK1 (17p13.2) / USO1 (4q21.1)RABEP1 (17p13.2) / MINK1 (17p13.2)
RANBP1 (22q11.21) / MINK1 (17p13.2)RPL5 (1p22.1) / MINK1 (17p13.2)MINK1 USO1
MINK1 NQO2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MINK1   17565
Cards
Entrez_Gene (NCBI)MINK1  50488  misshapen-like kinase 1
AliasesB55; MAP4K6; MINK; YSK2; 
ZC3; hMINK; hMINKbeta
GeneCards (Weizmann)MINK1
Ensembl hg19 (Hinxton)ENSG00000141503 [Gene_View]  chr17:4736635-4801356 [Contig_View]  MINK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141503 [Gene_View]  chr17:4736635-4801356 [Contig_View]  MINK1 [Vega]
ICGC DataPortalENSG00000141503
TCGA cBioPortalMINK1
AceView (NCBI)MINK1
Genatlas (Paris)MINK1
WikiGenes50488
SOURCE (Princeton)MINK1
Genetics Home Reference (NIH)MINK1
Genomic and cartography
GoldenPath hg19 (UCSC)MINK1  -     chr17:4736635-4801356 +  17p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MINK1  -     17p13.2   [Description]    (hg38-Dec_2013)
EnsemblMINK1 - 17p13.2 [CytoView hg19]  MINK1 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIMINK1 [Mapview hg19]  MINK1 [Mapview hg38]
OMIM609426   
Gene and transcription
Genbank (Entrez)AB035698 AB041926 AB209450 AF218033 AK096610
RefSeq transcript (Entrez)NM_001024937 NM_015716 NM_153827 NM_170663
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_028005 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)MINK1
Cluster EST : UnigeneHs.443417 [ NCBI ]
CGAP (NCI)Hs.443417
Alternative Splicing GalleryENSG00000141503
Gene ExpressionMINK1 [ NCBI-GEO ]   MINK1 [ EBI - ARRAY_EXPRESS ]   MINK1 [ SEEK ]   MINK1 [ MEM ]
Gene Expression Viewer (FireBrowse)MINK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50488
GTEX Portal (Tissue expression)MINK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N4C8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N4C8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N4C8
Splice isoforms : SwissVarQ8N4C8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8N4C8
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Citron    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MINK1
DMDM Disease mutations50488
Blocks (Seattle)MINK1
SuperfamilyQ8N4C8
Human Protein AtlasENSG00000141503
Peptide AtlasQ8N4C8
HPRD11366
IPIIPI00166680   IPI00955938   IPI00218498   IPI00479498   
Protein Interaction databases
DIP (DOE-UCLA)Q8N4C8
IntAct (EBI)Q8N4C8
FunCoupENSG00000141503
BioGRIDMINK1
STRING (EMBL)MINK1
ZODIACMINK1
Ontologies - Pathways
QuickGOQ8N4C8
Ontology : AmiGOregulation of cell-matrix adhesion  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  protein phosphorylation  protein phosphorylation  response to stress  JNK cascade  synaptic transmission  multicellular organismal development  postsynaptic density  regulation of cell-cell adhesion  microvillus assembly  cell junction  regulation of cell migration  axon  dendrite  actin cytoskeleton reorganization  intracellular signal transduction  negative thymic T cell selection  postsynaptic membrane  positive regulation of JNK cascade  protein autophosphorylation  dendrite morphogenesis  extracellular exosome  regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  
Ontology : EGO-EBIregulation of cell-matrix adhesion  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  protein phosphorylation  protein phosphorylation  response to stress  JNK cascade  synaptic transmission  multicellular organismal development  postsynaptic density  regulation of cell-cell adhesion  microvillus assembly  cell junction  regulation of cell migration  axon  dendrite  actin cytoskeleton reorganization  intracellular signal transduction  negative thymic T cell selection  postsynaptic membrane  positive regulation of JNK cascade  protein autophosphorylation  dendrite morphogenesis  extracellular exosome  regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  
NDEx NetworkMINK1
Atlas of Cancer Signalling NetworkMINK1
Wikipedia pathwaysMINK1
Orthology - Evolution
OrthoDB50488
GeneTree (enSembl)ENSG00000141503
Phylogenetic Trees/Animal Genes : TreeFamMINK1
HOVERGENQ8N4C8
HOGENOMQ8N4C8
Homologs : HomoloGeneMINK1
Homology/Alignments : Family Browser (UCSC)MINK1
Gene fusions - Rearrangements
Fusion: TCGAMINK1 USO1
Fusion: TCGAMINK1 NQO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMINK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MINK1
dbVarMINK1
ClinVarMINK1
1000_GenomesMINK1 
Exome Variant ServerMINK1
ExAC (Exome Aggregation Consortium)MINK1 (select the gene name)
Genetic variants : HAPMAP50488
Genomic Variants (DGV)MINK1 [DGVbeta]
DECIPHER (Syndromes)17:4736635-4801356  ENSG00000141503
CONAN: Copy Number AnalysisMINK1 
Mutations
ICGC Data PortalMINK1 
TCGA Data PortalMINK1 
Broad Tumor PortalMINK1
OASIS PortalMINK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMINK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMINK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MINK1
DgiDB (Drug Gene Interaction Database)MINK1
DoCM (Curated mutations)MINK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MINK1 (select a term)
intoGenMINK1
Cancer3DMINK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609426   
Orphanet
MedgenMINK1
Genetic Testing Registry MINK1
NextProtQ8N4C8 [Medical]
TSGene50488
GENETestsMINK1
Huge Navigator MINK1 [HugePedia]
snp3D : Map Gene to Disease50488
BioCentury BCIQMINK1
ClinGenMINK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50488
Chemical/Pharm GKB GenePA134910641
Clinical trialMINK1
Miscellaneous
canSAR (ICR)MINK1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMINK1
EVEXMINK1
GoPubMedMINK1
iHOPMINK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:28:21 CET 2017

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