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MIOX (myo-inositol oxygenase)

Identity

Alias_namesALDRL6
aldehyde reductase (aldose reductase) like 6
Other alias
HGNC (Hugo) MIOX
LocusID (NCBI) 55586
Atlas_Id 68993
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50925213 and ends at 50928750 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADM2 (22q13.33) / MIOX (22q13.33)NUMA1 (11q13.4) / MIOX (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MIOX   14522
Cards
Entrez_Gene (NCBI)MIOX  55586  myo-inositol oxygenase
AliasesALDRL6
GeneCards (Weizmann)MIOX
Ensembl hg19 (Hinxton)ENSG00000100253 [Gene_View]  chr22:50925213-50928750 [Contig_View]  MIOX [Vega]
Ensembl hg38 (Hinxton)ENSG00000100253 [Gene_View]  chr22:50925213-50928750 [Contig_View]  MIOX [Vega]
ICGC DataPortalENSG00000100253
TCGA cBioPortalMIOX
AceView (NCBI)MIOX
Genatlas (Paris)MIOX
WikiGenes55586
SOURCE (Princeton)MIOX
Genetics Home Reference (NIH)MIOX
Genomic and cartography
GoldenPath hg19 (UCSC)MIOX  -     chr22:50925213-50928750 +  22q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MIOX  -     22q13.33   [Description]    (hg38-Dec_2013)
EnsemblMIOX - 22q13.33 [CytoView hg19]  MIOX - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIMIOX [Mapview hg19]  MIOX [Mapview hg38]
OMIM606774   
Gene and transcription
Genbank (Entrez)AF197129 AY064416 AY738258 BC012025 BC064395
RefSeq transcript (Entrez)NM_017584
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011526 NW_004929431
Consensus coding sequences : CCDS (NCBI)MIOX
Cluster EST : UnigeneHs.129227 [ NCBI ]
CGAP (NCI)Hs.129227
Alternative Splicing GalleryENSG00000100253
Gene ExpressionMIOX [ NCBI-GEO ]   MIOX [ EBI - ARRAY_EXPRESS ]   MIOX [ SEEK ]   MIOX [ MEM ]
Gene Expression Viewer (FireBrowse)MIOX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55586
GTEX Portal (Tissue expression)MIOX
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGB7
Splice isoforms : SwissVarQ9UGB7
Catalytic activity : Enzyme1.13.99.1 [ Enzyme-Expasy ]   1.13.99.11.13.99.1 [ IntEnz-EBI ]   1.13.99.1 [ BRENDA ]   1.13.99.1 [ KEGG ]   
PhosPhoSitePlusQ9UGB7
Domains : Interpro (EBI)Inositol_oxygenase   
Domain families : Pfam (Sanger)DUF706 (PF05153)   
Domain families : Pfam (NCBI)pfam05153   
Conserved Domain (NCBI)MIOX
DMDM Disease mutations55586
Blocks (Seattle)MIOX
PDB (SRS)2IBN   
PDB (PDBSum)2IBN   
PDB (IMB)2IBN   
PDB (RSDB)2IBN   
Structural Biology KnowledgeBase2IBN   
SCOP (Structural Classification of Proteins)2IBN   
CATH (Classification of proteins structures)2IBN   
SuperfamilyQ9UGB7
Human Protein AtlasENSG00000100253
Peptide AtlasQ9UGB7
HPRD12443
IPIIPI00099088   IPI00807628   IPI00853406   IPI00852977   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGB7
IntAct (EBI)Q9UGB7
FunCoupENSG00000100253
BioGRIDMIOX
STRING (EMBL)MIOX
ZODIACMIOX
Ontologies - Pathways
QuickGOQ9UGB7
Ontology : AmiGOaldo-keto reductase (NADP) activity  cytoplasm  ferric iron binding  inclusion body  oxidoreductase activity, acting on NAD(P)H  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen  inositol catabolic process  inositol catabolic process  inositol oxygenase activity  NADP binding  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIaldo-keto reductase (NADP) activity  cytoplasm  ferric iron binding  inclusion body  oxidoreductase activity, acting on NAD(P)H  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen  inositol catabolic process  inositol catabolic process  inositol oxygenase activity  NADP binding  oxidation-reduction process  extracellular exosome  
Pathways : KEGGAscorbate and aldarate metabolism    Inositol phosphate metabolism   
NDEx NetworkMIOX
Atlas of Cancer Signalling NetworkMIOX
Wikipedia pathwaysMIOX
Orthology - Evolution
OrthoDB55586
GeneTree (enSembl)ENSG00000100253
Phylogenetic Trees/Animal Genes : TreeFamMIOX
HOVERGENQ9UGB7
HOGENOMQ9UGB7
Homologs : HomoloGeneMIOX
Homology/Alignments : Family Browser (UCSC)MIOX
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMIOX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MIOX
dbVarMIOX
ClinVarMIOX
1000_GenomesMIOX 
Exome Variant ServerMIOX
ExAC (Exome Aggregation Consortium)MIOX (select the gene name)
Genetic variants : HAPMAP55586
Genomic Variants (DGV)MIOX [DGVbeta]
DECIPHER (Syndromes)22:50925213-50928750  ENSG00000100253
CONAN: Copy Number AnalysisMIOX 
Mutations
ICGC Data PortalMIOX 
TCGA Data PortalMIOX 
Broad Tumor PortalMIOX
OASIS PortalMIOX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMIOX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMIOX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MIOX
DgiDB (Drug Gene Interaction Database)MIOX
DoCM (Curated mutations)MIOX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MIOX (select a term)
intoGenMIOX
Cancer3DMIOX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606774   
Orphanet
MedgenMIOX
Genetic Testing Registry MIOX
NextProtQ9UGB7 [Medical]
TSGene55586
GENETestsMIOX
Huge Navigator MIOX [HugePedia]
snp3D : Map Gene to Disease55586
BioCentury BCIQMIOX
ClinGenMIOX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55586
Chemical/Pharm GKB GenePA24716
Clinical trialMIOX
Miscellaneous
canSAR (ICR)MIOX (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMIOX
EVEXMIOX
GoPubMedMIOX
iHOPMIOX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:28:22 CET 2017

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