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MIR107 (MicroRNA 107)

Written2013-12Priyanka Sharma, Rinu Sharma
Research Scholar, University School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi-110078, India (PS); University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector 16 C Dwarka, New Delhi-110078, India (RS)

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Other namesMIRN107
HGNC (Hugo) MIR107
LocusID (NCBI) 406901
Atlas_Id 51325
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 91352504 and ends at 91352584 bp from pter ( according to hg19-Feb_2009)  [Mapping MIR107.png]


  Table 1: Overlapping Transcripts.
Description miR-107 is located on the 10th chromosome. miR-107 gene is of 87 bp and starts from 91352500 bp from pter and ends at 91352586 bp from pter on minus strand. Total number of exon present is one and coding exon is 0.
miR-107 paralogs include miR-103(1), miR103(2) and miR107 which reside in three homologous PANK genes - PANK3, PANK2 and PANK1 respectively. miR-103 is in a PANK gene intron but miR-107 is located intergenically (Finnerty et al., 2010).
Transcription hsa-miR-107 is a product of gene ENSG00000198997 and has 1 transcript ENST00000362127 of 87 bp. Precursor miRNA transcribed by this gene is of 81 base pairs (location: complement (91352504..91352584) on DNA and 1:81 on RNA) while mature miRNA is of 23 bp transcribed from sequence located at (91352513..91352535)bp on minus strand of DNA and 50:72 bp on RNA. Transcript is intron-less.
Pseudogene Paralogs: hsa-miR-107 has two paralogs:
1)hsa-miR-103-1 HGNC: 31490
2)hsa-miR-103-2 HGNC: 31491


Note No protein product.


Note SNP

AllelePos=51; totalLen=101; snpclass=1; alleles='A/G'. (NCBI dbSNP)

AllelePos=101; totalLen=201; snpclass=1; alleles='C/T'. (NCBI dbSNP)
- SNP Loc relative to pre-miR 40
- Primary miRNA Eenergy: -29.6 kcal/mol
- SNP-miRNA Eenergy: -30.3kcal/mol
- ΔΔG: -0.7kcal/mol (microRNA-related Single Nucleotide Polymorphims)
For miRNA-107 NCBI Reference Sequence NR_029524.1 (Contig NT_030059.13) following 56 SNPs have been reported in dbSNP (NCBI dbSNP).

  Table 2

Implicated in

Entity Breast cancer
Oncogenesis miR-107 was reported to be over expressed in malignant tissues from patients with advanced breast cancer, and its expression showed an inverse correlation with let-7 expression in tumors and in cancer cell lines Ectopic expression of miR-107 in human cancer cell lines led to destabilization of mature let-7, increased expression of let-7 targets, and increased malignant phenotypes (Chen et al., 2011).
Entity Colon cancer
Oncogenesis P53-induced miR-107 inhibited HIF-1 and tumor angiogenesis in colon cancer specimens. Furthermore, overexpression of miR-107 in tumor cells suppresses tumor angiogenesis, tumor growth, and tumor VEGF expression in mice (Yamakuchi et al., 2010).
Entity Colorectal cancer
Oncogenesis miR-103/107 targeted the known metastasis suppressors death-associated protein kinase (DAPK) and Krüppel-like factor 4 (KLF4) in colorectal cancer cells, resulting in increased cell motility and cell-matrix adhesion and decreased cell-cell adhesion and epithelial marker expression. miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness (Chen et al., 2012).
Entity Esophageal cancer
Oncogenesis Circulating and tissue miR-107 was found to be downregulated in esophageal cancer tissues and sera samples as compared to matched non-malignant tissues and healthy controls respectively (Sharma et al., 2013).
Entity Gastric cancer
Prognosis miR-107 expression in gastric cancer tissues was demonstrated as an independent prognostic factor for overall survival rates (OS) and disease-free survival rates (DFS). OS and DFS of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression (Inoue et al., 2012).
Oncogenesis Its ectopic expression reduced both mRNA and protein expression levels of CDK6, inhibited proliferation, blocked invasion of gastric cancer cells and also induced G1 cell cycle arrest (Feng et al., 2012). miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. Moreover, significant inverse correlation was found between miR-107 and DICER1 mRNA (Inoue et al., 2012) and it was demonstrated that miR107 regulates tumor invasion and metastasis in gastric cancer by targeting DICER1 (Li et al., 2011).
Entity Glioma
Oncogenesis miR-107 inhibited proliferation of Glioma cells (Chen et al., 2013a), downregulated expression of CDK6 and notch-2 and also inhibited glioma cell migration and invasion by modulating notch-2 expression (Chen et al., 2013b). He et al., (2013) reported that upregulation of miR-107 suppressed glioma cell growth through directly targeting SALL4, leading to the activation of FADD/caspase-8/caspase-3/caspase-7 signaling pathway of cell apoptosis.
Entity Head and neck squamous cell carcinoma
Oncogenesis microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cε. Treatment with miR-107 significantly blocked cell proliferation, DNA replication, colony formation and invasion in head and neck squamous cell carcinoma (HNSCC) cell lines (Datta et al., 2012). Moreover, Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of HNSCC (Piao et al., 2012).
Entity B-cell chronic lymphocytic leukemia
Oncogenesis Down-regulation of miRNA-107 due to epigenetic transcriptional silencing results in overexpression of its target gene PLAG1 (pleomorphic adenoma gene 1), a well known oncogenic transcription factor (Pallasch, 2009).
Entity Lung cancer
Oncogenesis MiR-107 suppressed cell proliferation in human non-small cell lung cancer cell lines (Takahashi et al., 2009) and induced G1 cell cycle arrest.
Entity Neuroblastoma
Oncogenesis miR-103 and miR-107 regulate CDK5R1 expression and their overexpression, as well as CDK5R1 silencing, caused a reduction in migration ability of neuroblastoma cells (Moncini et al., 2011).
Entity Pancreatic cancer
Oncogenesis Lee et al. (2009) reported that epigenetic silencing of miR-107 regulates CDK6 expression in pancreatic cancer.
Entity Pituitary adenomas
Oncogenesis miR-107 is overexpressed in Pituitary adenomas and may act as tumor suppressor. Pituitary tumor suppressor gene AIP (aryl hydrocarbon receptor-interacting protein) is a miR-107 target and both may have roles in tumorigenesis (Trivellin et al., 2012). Recent studies have demonstrated regulation of miR-107 by P53 tumor suppressor.
Entity Prostate cancer
Oncogenesis Multiple members of the miR-107 gene group repress mitogen and growth factor granulin (GRN) protein levels when transfected into prostate cancer cells (Wang et al., 2010a). GRN is dysregulated via miR-15/107 gene group in multiple human cancers, which may provide a potential common therapeutic target.
Entity Various cancers
Cytogenetics - Entrez Gene cytogenetic band: 10q23.31
- Ensembl cytogenetic band: 10q23.31
- HGNC cytogenetic band: 10q23.31
- Type: Cytoband, Source: UCSC, Length: 3300000, Stain: gpos75 (Database of Genomic Variants)
Entity Hypoxia and angiogenesis
Note miR-107 mediates p53 regulation of hypoxic signaling and tumor angiogenesis in colon cancer. It regulates hypoxia signaling by suppressing expression of hypoxia inducible factor-1β (HIF-1β). Moreover, overexpression of miR-107 in tumor cells suppresses tumor angiogenesis, tumor growth and tumor VEGF expression in mice (Yamakuchi et al., 2010).
Entity Metabolism
Note miR-107 has been implicated in metabolism of cellular lipids (Wilfred et al., 2007) and in regulation of insulin sensitivity. Caveolin-1, a critical regulator of insulin receptor has been identified as a direct target of miR-103/107 (Trajkovski et al., 2011). Human CYP2C8, a member of CYP2C subfamily of cytochrome P450 enzymes is also post-transcriptionally regulated by microRNAs 103 and 107 in human liver (Zhang et al., 2012).
Entity Alzheimer's
Note Expression of miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 (Wang et al., 2008). Moreover, miR-107 expression tended to correlate in a negative fashion with neuritic plaque(NPs) and neurofibrillary tangle (NFTs) (Nelson and Wang, 2010) microRNAs-107/miR-103 represse translation of actin-binding protein cofilin, and their reduced levels are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of Alzheimer's disease (Yao et al., 2010).
Entity Brain injury and neurodegenerative disease
Note miR-107 contributes to regulation of granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease (Wang et al., 2010b).
Entity Schizophrenia
Note Increased levels of miR-107 contribute to the marked loss of cortical CHRM1 in schizophrenia which may be a differentiating pathophysiology (Scarr et al., 2013).


  Table 3. LOH and homozygous deletion on chromosome 10q (10q22-10q23) in primary hepatocellular carcinoma (Zhu et al., 2004). See Supplementary Table S1.


miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4.
Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT, Chen RH.
Cancer Res. 2012 Jul 15;72(14):3631-41. doi: 10.1158/0008-5472.CAN-12-0667. Epub 2012 May 16.
PMID 22593189
MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression.
Chen L, Chen XR, Zhang R, Li P, Liu Y, Yan K, Jiang XD.
J Neurooncol. 2013a Mar;112(1):59-66. doi: 10.1007/s11060-012-1037-7. Epub 2013 Jan 9.
PMID 23299462
P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2.
Chen L, Zhang R, Li P, Liu Y, Qin K, Fa ZQ, Liu YJ, Ke YQ, Jiang XD.
Neurosci Lett. 2013b Feb 8;534:327-32. doi: 10.1016/j.neulet.2012.11.047. Epub 2012 Dec 7.
PMID 23220650
miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans.
Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, Kuo ML.
J Clin Invest. 2011 Sep;121(9):3442-55. doi: 10.1172/JCI45390. Epub 2011 Aug 15.
PMID 21841313
microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cε.
Datta J, Smith A, Lang JC, Islam M, Dutt D, Teknos TN, Pan Q.
Oncogene. 2012 Sep 6;31(36):4045-53. doi: 10.1038/onc.2011.565. Epub 2011 Dec 12.
PMID 22158047
The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases.
Finnerty JR, Wang WX, Hebert SS, Wilfred BR, Mao G, Nelson PT.
J Mol Biol. 2010 Sep 24;402(3):491-509. doi: 10.1016/j.jmb.2010.07.051. Epub 2010 Aug 1. (REVIEW)
PMID 20678503
Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4.
He J1, Zhang W, Zhou Q, Zhao T, Song Y, Chai L, Li Y.
Int J Biochem Cell Biol. 2013 Sep;45(9):1962-73. doi: 10.1016/j.biocel.2013.06.008. Epub 2013 Jun 28.
PMID 23811124
Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer.
Inoue T1, Iinuma H, Ogawa E, Inaba T, Fukushima R.
Oncol Rep. 2012 Jun;27(6):1759-64. doi: 10.3892/or.2012.1709. Epub 2012 Mar 7.
PMID 22407237
Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer.
Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins MG, Mendell JT, Maitra A.
Pancreatology. 2009;9(3):293-301. doi: 10.1159/000186051. Epub 2009 Apr 29.
PMID 19407485
MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer.
Li X, Zhang Y, Shi Y, Dong G, Liang J, Han Y, Wang X, Zhao Q, Ding J, Wu K, Fan D.
J Cell Mol Med. 2011 Sep;15(9):1887-95. doi: 10.1111/j.1582-4934.2010.01194.x.
PMID 21029372
The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.
Moncini S, Salvi A, Zuccotti P, Viero G, Quattrone A, Barlati S, De Petro G, Venturin M, Riva P.
PLoS One. 2011;6(5):e20038. doi: 10.1371/journal.pone.0020038. Epub 2011 May 23.
PMID 21625387
MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study.
Nelson PT, Wang WX.
J Alzheimers Dis. 2010;21(1):75-9. doi: 10.3233/JAD-2010-091603.
PMID 20413881
miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia.
Pallasch CP, Patz M, Park YJ, Hagist S, Eggle D, Claus R, Debey-Pascher S, Schulz A, Frenzel LP, Claasen J, Kutsch N, Krause G, Mayr C, Rosenwald A, Plass C, Schultze JL, Hallek M, Wendtner CM.
Blood. 2009 Oct 8;114(15):3255-64. doi: 10.1182/blood-2009-06-229898. Epub 2009 Aug 19.
PMID 19692702
Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma.
Piao L, Zhang M, Datta J, Xie X, Su T, Li H, Teknos TN, Pan Q.
Mol Ther. 2012 Jun;20(6):1261-9. doi: 10.1038/mt.2012.67. Epub 2012 Apr 10.
PMID 22491216
Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA.
Scarr E, Craig JM, Cairns MJ, Seo MS, Galati JC, Beveridge NJ, Gibbons A, Juzva S, Weinrich B, Parkinson-Bates M, Carroll AP, Saffery R, Dean B.
Transl Psychiatry. 2013 Feb 19;3:e230. doi: 10.1038/tp.2013.3.
PMID 23423139
Decreased levels of circulating and tissue miR-107 in human esophageal cancer.
Sharma P, Saraya A, Gupta P, Sharma R.
Biomarkers. 2013 Jun;18(4):322-30. doi: 10.3109/1354750X.2013.781677. Epub 2013 Apr 29.
PMID 23627613
MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines.
Takahashi Y, Forrest AR, Maeno E, Hashimoto T, Daub CO, Yasuda J.
PLoS One. 2009 Aug 18;4(8):e6677. doi: 10.1371/journal.pone.0006677.
PMID 19688090
MicroRNAs 103 and 107 regulate insulin sensitivity.
Trajkovski M, Hausser J, Soutschek J, Bhat B, Akin A, Zavolan M, Heim MH, Stoffel M.
Nature. 2011 Jun 8;474(7353):649-53. doi: 10.1038/nature10112.
PMID 21654750
MicroRNA miR-107 is overexpressed in pituitary adenomas and inhibits the expression of aryl hydrocarbon receptor-interacting protein in vitro.
Trivellin G, Butz H, Delhove J, Igreja S, Chahal HS, Zivkovic V, McKay T, Patocs A, Grossman AB, Korbonits M.
Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E708-19. doi: 10.1152/ajpendo.00546.2011. Epub 2012 Jul 17.
PMID 22811466
Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group.
Wang WX, Kyprianou N, Wang X, Nelson PT.
Cancer Res. 2010a Nov 15;70(22):9137-42. doi: 10.1158/0008-5472.CAN-10-1684. Epub 2010 Sep 30.
PMID 20884628
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.
Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT.
J Neurosci. 2008 Jan 30;28(5):1213-23. doi: 10.1523/JNEUROSCI.5065-07.2008.
PMID 18234899
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease.
Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, Nelson PT.
Am J Pathol. 2010b Jul;177(1):334-45. doi: 10.2353/ajpath.2010.091202. Epub 2010 May 20.
PMID 20489155
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways.
Wilfred BR, Wang WX, Nelson PT.
Mol Genet Metab. 2007 Jul;91(3):209-17. Epub 2007 May 22. (REVIEW)
PMID 17521938
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.
Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ.
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-9. doi: 10.1073/pnas.0911082107. Epub 2010 Mar 22.
PMID 20308559
MicroRNA-related cofilin abnormality in Alzheimer's disease.
Yao J, Hennessey T, Flynt A, Lai E, Beal MF, Lin MT.
PLoS One. 2010 Dec 16;5(12):e15546. doi: 10.1371/journal.pone.0015546.
PMID 21179570
Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver.
Zhang SY, Surapureddi S, Coulter S, Ferguson SS, Goldstein JA.
Mol Pharmacol. 2012 Sep;82(3):529-40. doi: 10.1124/mol.112.078386. Epub 2012 Jun 20.
PMID 22723340
Loss of heterozygosity on chromosome 10q22-10q23 and 22q11.2-22q12.1 and p53 gene in primary hepatocellular carcinoma.
Zhu GN, Zuo L, Zhou Q, Zhang SM, Zhu HQ, Gui SY, Wang Y.
World J Gastroenterol. 2004 Jul 1;10(13):1975-8.
PMID 15222050


This paper should be referenced as such :
Sharma, P ; Sharma, R
MIR107 (MicroRNA 107)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(8):559-564.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

HGNC (Hugo)MIR107   31496
Entrez_Gene (NCBI)MIR107  406901  microRNA 107
AliasesMIRN107; miR-107
GeneCards (Weizmann)MIR107
Ensembl hg19 (Hinxton)ENSG00000198997 [Gene_View]  chr10:91352504-91352584 [Contig_View]  MIR107 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198997 [Gene_View]  chr10:91352504-91352584 [Contig_View]  MIR107 [Vega]
ICGC DataPortalENSG00000198997
TCGA cBioPortalMIR107
AceView (NCBI)MIR107
Genatlas (Paris)MIR107
SOURCE (Princeton)MIR107
Genetics Home Reference (NIH)MIR107
Genomic and cartography
GoldenPath hg19 (UCSC)MIR107  -     chr10:91352504-91352584 -  10q23.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MIR107  -     10q23.31   [Description]    (hg38-Dec_2013)
EnsemblMIR107 - 10q23.31 [CytoView hg19]  MIR107 - 10q23.31 [CytoView hg38]
Mapping of homologs : NCBIMIR107 [Mapview hg19]  MIR107 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF480505 AF480550 AJ550401 LM608197
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_029474 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)MIR107
Alternative Splicing GalleryENSG00000198997
Gene ExpressionMIR107 [ NCBI-GEO ]   MIR107 [ EBI - ARRAY_EXPRESS ]   MIR107 [ SEEK ]   MIR107 [ MEM ]
Gene Expression Viewer (FireBrowse)MIR107 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)406901
GTEX Portal (Tissue expression)MIR107
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations406901
Blocks (Seattle)MIR107
Human Protein AtlasENSG00000198997
Protein Interaction databases
Ontologies - Pathways
Huge Navigator MIR107 [HugePedia]
snp3D : Map Gene to Disease406901
BioCentury BCIQMIR107
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD406901
Chemical/Pharm GKB GenePA164722344
Clinical trialMIR107
canSAR (ICR)MIR107 (select the gene name)
Other databaseMirbase
Other databaseMicroRNA related Single Nucleotide Polymorphism
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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