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MIR135A1 (microRNA 135a-1)

Written2014-02Alfons Navarro, Marina Díaz-Beyá, Mariano Monzó
Molecular Oncology, Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, Barcelona, Spain (AN, MM); Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (MDB)

(Note : for Links provided by Atlas : click)


Alias (NCBI)MIRN135-1
HGNC (Hugo) MIR135A1
HGNC Alias symbhsa-mir-135-1
HGNC Previous nameMIRN135-1
HGNC Previous namemicroRNA 135-1
LocusID (NCBI) 406925
Atlas_Id 50328
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 52294219 and ends at 52294308 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MIR135A1.png]
Local_order Genes flanking MIR135A1 oriented from centromere to telomere on 3p21.1:
- PHF7: PHD finger protein 7, 3p21.1
- BAP1: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), 3p21.31-p21.2
- DNAH1: dynein, axonemal, heavy chain 1, 3p21.1
- MIR135A1
- GLYCTK-AS1: GLYCTK Antisense RNA 1 (Non-protein coding), 3p21.1
- GLYCTK: glycerate kinase, 3p21.1
- TCONS_00006853; lnc-GLYCTK-1, 3p21.1
- WDR82: WD repeat domain 82, 3p21.2
- MIRLET7G: microRNA let-7g, 3p21.1.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


  A. Stem-loop structure of hsa-mir-135a-1. B. Genomic location of MIR135A 1 and its host genes.
Description The gene is located in the intron 1 of GLYCTK-AS1/RP11 gene (sense) and in the exon 4 of GLYCTK (antisense). The precursor length is 90 nt.
Transcription The transcription of miR-135a is regulated by FOXM1 in hepatocellular carcinoma (Liu et al., 2012).
BMP2 inhibits miR-135a expression during osteoblast differentiation (Li et al., 2008).
Pseudogene No reported pseudogenes.


Note MicroRNAs are not translated into amino acids.


Note Deletions of miR-135a-1 gene have been described in medulloblastomas, where 16/48 (33%) of medulloblastoma patients had a deletion of miR-135a-1 gene (Lv et al., 2012).

Implicated in

Entity Cancer
Entity Colorectal cancer (CRC)
Note Interestingly, treating CRC cell lines with mistletoe lecitin-I, degrades precursor of some microRNAs, including pre-mir-135a, thus dowregulating miR-135 and upregulating APC and increasing beta-catenin phosphorylation (Li et al., 2011).
Prognosis A prognostic miRNA signature composed of miR-135a, miR-21, miR-335, miR-206 and let-7a was useful to detect the presence of metastasis (Vickers et al., 2012).
Oncogenesis Oncogene.
miRNA expression: Overexpression among colorectal adenome and carcinome in comparison with normal tissue. miR-135 family (miR-135a and miR-135b) overexpression during CRC progression (in patients) (Nagel et al., 2008). Consistently, a study comparing patient samples, healthy controls and cell lines showed overexpression in CRC samples (Zhou et al., 2012). Another study also showed overexpression associated with progression and metastasis (Vickers et al., 2012).
Targets: Adenomatous polyposis coli (APC) (Nagel et al., 2008). Metastasis suppressor 1 (MTSS1) (Zhou et al., 2012).
Function: miR-135a and miR-135b inhibits APC translation (independently of mutational status of APC) activating downstream Wnt pathway activity and induce beta-catenin signaling (Nagel et al., 2008). In CRC cell lines, miR-135a overexpression increased proliferation and promoted mobility and invasion in part by targeting MTSS1 (Zhou et al., 2012).
Entity Gastric cancer
Oncogenesis Tumor suppressor (Wu H et al., 2012).
miRNA expression: Downregulation in gastric cancer patient samples in comparison with adjacent normal tissue.
Targets: JAK2 (Janus kinase 2)
Function: miR-135a overexpression produces downregulation of JAK2 levels reducing cell proliferation and colony formation. It also reduces p-STAT3 (phospho signal transducer and activator of transcription 3) activation and cyclin D1 and Bcl-x (BCL2-like1).
Entity Hepatocellular carcinoma (HCC)
Prognosis In a cohort of 50 patients, overexpression of miR-135a identified a group of patients with worse OS end DFS among patients with PVTT.
Oncogenesis Oncogene (Liu et al., 2012).
miRNA expression: Overexpression of miR-135a in samples from HCC with portal vein tumor thrombus (PVTT) - that is considered a special type of HCC metastasis - compared with parenchyma tumor nodes.
Targets: MTSS
Function: miR-135a promotes invasion and metastasis in vitro and in mouse models of HCC. Reducing miR-135a leads to reduced PVTT. The transcription of miR-135a is regulated by FOXM1.
Entity Breast cancer
Oncogenesis Oncogene (Chen et al., 2012).
miRNA expression: Overexpression in metastasic breast tumors in comparison with benign tumor patient samples. Upregulation in the highly invasive breast cancer cell line BT 549 in comparison with other breast cancer cell lines.
Targets: HOXA10 (homeobox A10).
Function: miR-135a promotes the migration and invasion of breast cancer cells at least in part through HOXA10.
Entity Malignant glioma
Oncogenesis Tumor suppressor (Wu S et al., 2012).
miRNA expression: Downregulated in glioma in comparison with normal glia. miRNA-135a correlated negatively with the pathological grading of human glioma tissue samples.
Targets: STAT6 (signal transducer and activator of transcription 6), SMAD5 (SMAD family member 5), BMPR2 (bone morphogenetic protein receptor, type II).
Function: miR-135a selectively induces mitochondria-dependent apoptosis of malignant glioma by targeting various genes (STAT6, SMAD5, BMPR2). Interestingly it doesn't affect normal glia cells.
Entity Lung cancer
Oncogenesis Tumor suppressor (Cheng et al., 2013; Zhou et al., 2013).
miRNA expression: miR-135a/b downregulated in the cisplatin-resistant cell line A549R compared with the cisplatin-sensitive A549 cell line (Zhou, Qiu et al. 2013)
Targets: MCL1 (myeloid cell leukemia sequence 1) (Zhou et al., 2013), CD133 (Cheng et al., 2013).
Function: Overexpression of miR-135a/b reduced MCL1 and sensitized cell lines to cisplatin by modulation of apoptosis (Zhou et al., 2013). miR-135a/b suppressed CD133 only in CD133 with binding polymorphism rs2240688 CC or CA but not in genotype AA (Cheng et al., 2013).
Entity Classic Hodgkin lymphoma (cHL)
Prognosis In a cohort of 89 cHL patients, low miR-135a was associated with a higher risk of relapse and worse disease free survival.
Oncogenesis Tumor suppressor (Navarro et al., 2008; Navarro et al., 2009).
miRNA expression: Downregulated miR-135a in cHL patient lymph nodes in comparison with reactive non-tumor lymph nodes used as control.
Targets: JAK2.
Function: Overexpression of miR-135a increases apoptosis and decreases cellular growth in HL cell lines through regulation of JAK/STAT pathway and activation BcL-xL expression.
Entity Acute myeloid leukemia (AML)
Prognosis In a cohort of 85 intermediate risk AML (IR-AML) patients (later extended to 238 IR-AML patients), low expression of miR-135a identified a group of patients with a higher risk of relapse - both in the entire cohort and also within the unfavourable molecular subgroup (FLT3-ITD or wild-type NPM and CEBPA) (Díaz-Beyá et al., 2014).
Oncogenesis Tumor suppressor.
Entity Renal cell carcinoma
Oncogenesis Tumor suppressor (Hidaka et al., 2012).
miRNA expression: Lower expression of miR-135a observed in 10 cancer tissue samples compared to 5 adjacent non-cancer tissue samples.
Function: Effect on cell proliferation, where the miR-135a overexpression reduces cell viavility.
Entity Cervival cancer cell
Oncogenesis Oncogene (Leung et al., 2014).
miRNA expression: miR-135a is overexpressed in cervical squamous cell carcinoma in comparison with cervical intraepithelial neoplasia (precancerous lesions).
Targets: SIAH1 (in cervical cancer cells and cervical epithelial cells).
Function: Overexpression of miR-135a induced increased colony formation, anchorage-independent growth, and proliferation, cell-invasion and migration in cervical cancer cell lines. The inhibition of miR-135a on SIAH1 led to upregulation of beta-catenin activity, indicating that miR-135a induces transformation and enhances tumor growth. The authors analyzed the miR-135a-induced malignant transformation activity in cell lines with or without human papiloma virus (HPV) proteins (E6 and E7) and concluded that these proteins are necessary for miR-135a oncogenic activity. Also in xenografts, miR-135a improved the growth of cancer cells and the tumorigenic activity of HPV cells.
Entity Various tumor cell lines (HeLa cervical carcinoma, SW480 colon cancer, A375 melanoma, PANC-1 pancreatic tumor, and 293 epithelial kidney cells)
Note FAK is overexpressed in many cancers.
Oncogenesis Tumor suppressor (Golubovskaya et al., 2014).
Targets: FAK (focal adhesion kinase).
Function: miR-135a overexpression decreased FAK mRNA and protein levels, decreased cell invasion and increased sensitivity to doxorubicin, 5-fluorouacil and FAK inhibitor Y15.
Entity Various tumor cell lines
Oncogenesis Oncogene (Holleman et al., 2011).
miRNA expression: miR-135a levels were significantly upregulated in paclitaxel-resistant ovarian, lung, uterine, breast and prostate tumor cells lines derived from A549, PC-14, MCF-7, PC-3, SKOV-3 and MES-SA.
Targets: APC.
Function: miR-135a upregulation in vitro and in vivo is associated with paclitaxel resistance. Anti-miR-135a treatment in paclitaxel-resistant lung cancer xenografts restored sensitivity to paclitaxel, in part through the direct inhibition of APC expression.
Entity Metabolism
Entity Diabetes
Note miRNA expression: Overexpression in diabetic human and mouse skeletal muscle.
Targets: IRS2 (insulin receptor substrate 2).
Function: miR-135a inhibits IRS2, thus reducing glucose uptake into the cell. miR-135a overexpression attenuates insulin signaling and glucose uptake in skeletal muscle. In vivo, silencing miR-135a decreases hyperglicemia (Agarwal et al., 2013).
Entity Essential hypertension, renin-angiotensin-aldosteron system
Note Targets: NR3C2 (mineral corticoid receptor).
Function: In Hela cells, overexpression of miR-135a and miR-124 downregulates NR3C2 protein, indicating a role in the regulation of blood pressure (Sõber et al., 2010).
Entity Corticoid dependent stress response
Note Targets: NR3C2 (mineral corticoid receptor, other alias MR)
Function: In a mouse model, downregulation of miR-135a and miR-124 in amygdale after two hours of stress stimulus. Stress reaction by activation of corticosteroid signaling through NR3C2R. miR-135a and miR-124 are thus important components of the stress signaling response in the brain (Mannironi et al., 2013).
Entity Development, congenital disease and others
Entity Cryptorchid testis
Note miRNA expression: In rat models, low expression of miR-135a in undescended testis in comparison with that in contralateral normal testis. Higher miR-135a expression in the testes than in other organs. miR-135a is detected in spermatogonial stem cells.
Targets: FoxO1 (forehead box protein O1).
Functions: miR-135a contributes to spermatogonial stem cell maintenance through modulation of FoxO1 (Moritoki et al., 2014).
Entity Endometriosis
Note miRNA expression: Overexpressed in endometriosis in comparison with normal endometrial tissue (50 controls and 32 women with endometriosis).
Targets: HOXA10 (homeobox A10).
Function: miR135a expression in controls was increased during the proliferative phase, decreased at the time of ovulation, and increased during the luteal phase (Petracco et al., 2011).
Entity Osteogenesis
Note miRNA expression: Very low levels in differentiated osteoblast, downregulated during BMP2-mediated osteogenic differentiation.
Targets: SMAD5.
Function: miR-135a suppresses osteogenesis and inhibits differentiation of osteoprogenitors and the osteogenic phenotype in pluripotent cells by attenuating SMAD5. BMP2 inhibits miR-135a expression and permits osteoblast differentiation (Li et al., 2008).
Entity Muscle differentiation (myogenesis) and Duchenne muscular dystrophy (DMD)
Note miRNA expression: miR-135a is upregulated during myogenic differentiation. Overexpression of miR-135a is observed when the myoblasts are differentiated in human samples, cell lines and mouse model (Greco et al., 2009). miR-135a is part of the DMD miRNA signature (Greco et al., 2009) and is overexpressed in Duchenne muscle (Cesana et al., 2011).
Targets: MEF2C (myocyte enhancer factor 2C) (Cesana et al., 2011).
Function: Critical in myogenesis by targeting MEF2C. miR-135a inhibits MEF2C, leading to inhibition of muscle genes. LincRNA MD1 sponges miR-135a, allowing transcription of muscle genes. LincRNA MD1 is reduced in Duchenne muscle cells, so miR-135a is overexpressed and MEFC2 is downregulated (Cesana et al., 2011).
Entity Preimplantation embryo development
Note miRNA expression: Overexpressed in mouse zygote and decreased thereafter, indicating that it is a zygote-specific miRNA.
Targets: SIAH1A (E3 ubiquitin ligase seven in absentia homolog 1A).
Function: miR-135a modulates the first cell cleavage through regulation of Siah1a. When miR-135a is inhibited, first cell cleavage is suppressed. mir-135a regulates proteosomal degradation (Pang et al., 2011).
Entity Mouse embryonic stem cells
Note miRNA expression: Upregulated during mouse embryonic stem cell differentiation.
Targets: SIRT1 (sirtuin 1).
Function: Together with miR-181a, miR-181b, miR-9, miR-204 and miR-199b, miR-135a suppressed SIRT1 protein expression during mouse embryonic stem cell differentiation (Saunders et al., 2010).
Entity Bovine blastocyst development
Note miRNA expression: miR-135a is part of a downregulated miRNA signature in more mature stage (Goossens et al., 2013).
Entity Megakaryocytopoiesis
Note miRNA expression: A comparison between differentiated megakaryocytes with AML megakaryocytic cell lines found miR-135a higher in AML samples (Garzon et al., 2006).
Entity Hypoxia
Note miRNA expression: Downregulation of miR-135a (and miR199a-5p) in response to hypoxia.
Targets: FLAP (5-lipoxygenase activating protein) (Gonsalves and Kalra, 2010).


miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.
Agarwal P, Srivastava R, Srivastava AK, Ali S, Datta M.
Biochim Biophys Acta. 2013 Aug;1832(8):1294-303. doi: 10.1016/j.bbadis.2013.03.021. Epub 2013 Apr 8.
PMID 23579070
A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.
Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I.
Cell. 2011 Oct 14;147(2):358-69. doi: 10.1016/j.cell.2011.09.028.
PMID 22000014
miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10.
Chen Y, Zhang J, Wang H, Zhao J, Xu C, Du Y, Luo X, Zheng F, Liu R, Zhang H, Ma D.
BMC Cancer. 2012 Mar 23;12:111. doi: 10.1186/1471-2407-12-111.
PMID 22439757
A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression.
Cheng M, Yang L, Yang R, Yang X, Deng J, Yu B, Huang D, Zhang S, Wang H, Qiu F, Zhou Y, Lu J.
Carcinogenesis. 2013 Oct;34(10):2292-9. doi: 10.1093/carcin/bgt181. Epub 2013 May 28.
PMID 23715500
MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia.
Diaz-Beya M, Brunet S, Nomdedeu J, Tejero R, Diaz T, Pratcorona M, Tormo M, Ribera JM, Escoda L, Duarte R, Gallardo D, Heras I, Queipo de Llano MP, Bargay J, Monzo M, Sierra J, Navarro A, Esteve J.
Leukemia. 2014 Apr;28(4):804-12. doi: 10.1038/leu.2013.281. Epub 2013 Sep 27.
PMID 24072101
MicroRNA fingerprints during human megakaryocytopoiesis.
Garzon R, Pichiorri F, Palumbo T, Iuliano R, Cimmino A, Aqeilan R, Volinia S, Bhatt D, Alder H, Marcucci G, Calin GA, Liu CG, Bloomfield CD, Andreeff M, Croce CM.
Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5078-83. Epub 2006 Mar 20.
PMID 16549775
MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.
Golubovskaya VM, Sumbler B, Ho B, Yemma M, Cance WG.
Anticancer Agents Med Chem. 2014 Jan;14(1):18-28.
PMID 23438844
Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p.
Gonsalves CS, Kalra VK.
J Immunol. 2010 Apr 1;184(7):3878-88. doi: 10.4049/jimmunol.0902594. Epub 2010 Mar 1.
PMID 20194722
Regulatory microRNA network identification in bovine blastocyst development.
Goossens K, Mestdagh P, Lefever S, Van Poucke M, Van Zeveren A, Van Soom A, Vandesompele J, Peelman L.
Stem Cells Dev. 2013 Jul 1;22(13):1907-20. doi: 10.1089/scd.2012.0708. Epub 2013 Mar 15.
PMID 23398486
Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia.
Greco S, De Simone M, Colussi C, Zaccagnini G, Fasanaro P, Pescatori M, Cardani R, Perbellini R, Isaia E, Sale P, Meola G, Capogrossi MC, Gaetano C, Martelli F.
FASEB J. 2009 Oct;23(10):3335-46. doi: 10.1096/fj.08-128579. Epub 2009 Jun 15.
PMID 19528256
Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma.
Hidaka H, Seki N, Yoshino H, Yamasaki T, Yamada Y, Nohata N, Fuse M, Nakagawa M, Enokida H.
Oncotarget. 2012 Jan;3(1):44-57.
PMID 22294552
miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo.
Holleman A, Chung I, Olsen RR, Kwak B, Mizokami A, Saijo N, Parissenti A, Duan Z, Voest EE, Zetter BR.
Oncogene. 2011 Oct 27;30(43):4386-98. doi: 10.1038/onc.2011.148. Epub 2011 May 9.
PMID 21552288
miR-135a leads to cervical cancer cell transformation through regulation of beta-catenin via a SIAH1-dependent ubiquitin proteosomal pathway.
Leung CO, Deng W, Ye TM, Ngan HY, Tsao SW, Cheung AN, Pang RT, Yeung WS.
Carcinogenesis. 2014 Feb 25. [Epub ahead of print]
PMID 24503442
Down-regulation of some miRNAs by degrading their precursors contributes to anti-cancer effect of mistletoe lectin-I.
Li LN, Zhang HD, Zhi R, Yuan SJ.
Br J Pharmacol. 2011 Jan;162(2):349-64. doi: 10.1111/j.1476-5381.2010.01042.x.
PMID 20955366
A microRNA signature for a BMP2-induced osteoblast lineage commitment program.
Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian JB, Stein GS.
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13906-11. doi: 10.1073/pnas.0804438105. Epub 2008 Sep 10.
PMID 18784367
MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma.
Liu S, Guo W, Shi J, Li N, Yu X, Xue J, Fu X, Chu K, Lu C, Zhao J, Xie D, Wu M, Cheng S, Liu S.
J Hepatol. 2012 Feb;56(2):389-96. doi: 10.1016/j.jhep.2011.08.008. Epub 2011 Aug 31.
PMID 21888875
Genetic alterations in microRNAs in medulloblastomas.
Lv SQ, Kim YH, Giulio F, Shalaby T, Nobusawa S, Yang H, Zhou Z, Grotzer M, Ohgaki H.
Brain Pathol. 2012 Mar;22(2):230-9. doi: 10.1111/j.1750-3639.2011.00523.x. Epub 2011 Sep 15.
PMID 21793975
Acute stress alters amygdala microRNA miR-135a and miR-124 expression: inferences for corticosteroid dependent stress response.
Mannironi C, Camon J, De Vito F, Biundo A, De Stefano ME, Persiconi I, Bozzoni I, Fragapane P, Mele A, Presutti C.
PLoS One. 2013 Sep 4;8(9):e73385. doi: 10.1371/journal.pone.0073385. eCollection 2013.
PMID 24023867
Expression Profiling of microRNA in Cryptorchid Testes: miR-135a Contributes to the Maintenance of Spermatogonial Stem Cells by Regulating FoxO1.
Moritoki Y, Hayashi Y, Mizuno K, Kamisawa H, Nishio H, Kurokawa S, Ugawa S, Kojima Y, Kohri K.
J Urol. 2014 Apr;191(4):1174-80. doi: 10.1016/j.juro.2013.10.137. Epub 2013 Oct 31.
PMID 24184258
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.
Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R.
Cancer Res. 2008 Jul 15;68(14):5795-802. doi: 10.1158/0008-5472.CAN-08-0951.
PMID 18632633
Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma.
Navarro A, Diaz T, Martinez A, Gaya A, Pons A, Gel B, Codony C, Ferrer G, Martinez C, Montserrat E, Monzo M.
Blood. 2009 Oct 1;114(14):2945-51. doi: 10.1182/blood-2009-02-204842. Epub 2009 Aug 7.
PMID 19666866
MicroRNA expression profiling in classic Hodgkin lymphoma.
Navarro A, Gaya A, Martinez A, Urbano-Ispizua A, Pons A, Balague O, Gel B, Abrisqueta P, Lopez-Guillermo A, Artells R, Montserrat E, Monzo M.
Blood. 2008 Mar 1;111(5):2825-32. Epub 2007 Dec 18.
PMID 18089852
miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression.
Pang RT, Liu WM, Leung CO, Ye TM, Kwan PC, Lee KF, Yeung WS.
PLoS One. 2011;6(11):e27878. doi: 10.1371/journal.pone.0027878. Epub 2011 Nov 22.
PMID 22132158
MicroRNA 135 regulates HOXA10 expression in endometriosis.
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS.
J Clin Endocrinol Metab. 2011 Dec;96(12):E1925-33. doi: 10.1210/jc.2011-1231. Epub 2011 Sep 28.
PMID 21956427
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E.
Aging (Albany NY). 2010 Jul;2(7):415-31.
PMID 20634564
MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression.
Sober S, Laan M, Annilo T.
Biochem Biophys Res Commun. 2010 Jan 1;391(1):727-32. doi: 10.1016/j.bbrc.2009.11.128. Epub 2009 Nov 26.
PMID 19944075
Stage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic disease.
Vickers MM, Bar J, Gorn-Hondermann I, Yarom N, Daneshmand M, Hanson JE, Addison CL, Asmis TR, Jonker DJ, Maroun J, Lorimer IA, Goss GD, Dimitroulakos J.
Clin Exp Metastasis. 2012 Feb;29(2):123-32. doi: 10.1007/s10585-011-9435-3. Epub 2011 Nov 26.
PMID 22120473
MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation.
Wu H, Huang M, Cao P, Wang T, Shu Y, Liu P.
Cancer Biol Ther. 2012 Mar;13(5):281-8. doi: 10.4161/cbt.18943. Epub 2012 Mar 1.
PMID 22310976
MiR-135a functions as a selective killer of malignant glioma.
Wu S, Lin Y, Xu D, Chen J, Shu M, Zhou Y, Zhu W, Su X, Zhou Y, Qiu P, Yan G.
Oncogene. 2012 Aug 23;31(34):3866-74. doi: 10.1038/onc.2011.551. Epub 2011 Dec 5.
PMID 22139076
miR-135a/b modulate cisplatin resistance of human lung cancer cell line by targeting MCL1.
Zhou L, Qiu T, Xu J, Wang T, Wang J, Zhou X, Huang Z, Zhu W, Shu Y, Liu P.
Pathol Oncol Res. 2013 Oct;19(4):677-83. doi: 10.1007/s12253-013-9630-4. Epub 2013 May 3.
PMID 23640248
MiR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro.
Zhou W, Li X, Liu F, Xiao Z, He M, Shen S, Liu S.
Acta Biochim Biophys Sin (Shanghai). 2012 Oct;44(10):838-46.
PMID 23017832


This paper should be referenced as such :
A Navarro, M Díaz-Beyá, M Monzó_
MIR135A1 (microRNA 135a-1)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(10):718-723.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)MIR135A1   31520
Entrez_Gene (NCBI)MIR135A1    microRNA 135a-1
AliasesMIRN135-1; MIRN135A1; mir-135a-1
GeneCards (Weizmann)MIR135A1
Ensembl hg19 (Hinxton)ENSG00000207926 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000207926 [Gene_View]  ENSG00000207926 [Sequence]  chr3:52294219-52294308 [Contig_View]  MIR135A1 [Vega]
ICGC DataPortalENSG00000207926
TCGA cBioPortalMIR135A1
AceView (NCBI)MIR135A1
Genatlas (Paris)MIR135A1
SOURCE (Princeton)MIR135A1
Genetics Home Reference (NIH)MIR135A1
Genomic and cartography
GoldenPath hg38 (UCSC)MIR135A1  -     chr3:52294219-52294308 -  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIR135A1  -     3p21.2   [Description]    (hg19-Feb_2009)
GoldenPathMIR135A1 - 3p21.2 [CytoView hg19]  MIR135A1 - 3p21.2 [CytoView hg38]
Genome Data Viewer NCBIMIR135A1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)LM608492
RefSeq transcript (Entrez)
Consensus coding sequences : CCDS (NCBI)MIR135A1
Gene ExpressionMIR135A1 [ NCBI-GEO ]   MIR135A1 [ EBI - ARRAY_EXPRESS ]   MIR135A1 [ SEEK ]   MIR135A1 [ MEM ]
Gene Expression Viewer (FireBrowse)MIR135A1 [ Firebrowse - Broad ]
GenevisibleExpression of MIR135A1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)406925
GTEX Portal (Tissue expression)MIR135A1
Human Protein AtlasENSG00000207926-MIR135A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MIR135A1
Human Protein Atlas [tissue]ENSG00000207926-MIR135A1 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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