MIR27B (microRNA 27b)

2012-01-01  

Identity

HGNC
MIR27B
LOCATION
9q22.32
LOCUSID
407019
ALIAS
MIR-27b,MIRN27B,miRNA27B

Other Information

Locus ID:

NCBI: 407019
MIM: 610636
HGNC: 31614
Ensembl: ENSG00000207864
miRBase:

Variants:

dbSNP: 407019
ClinVar: 407019
TCGA: ENSG00000207864
COSMIC: MIR27B

RNA/Proteins

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
198008672009microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma.132
201312572010MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.106
221844112012MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.76
201641872010MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization.68
235932822013miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal cancer.59
241332042013MicroRNA-27 (miR-27) targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells.53
221207192012MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells.52
251153962014The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer.50
215629282011PPARα is regulated by miR-21 and miR-27b in human liver.49
260659212015Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1.39

Citation

Dessen P

MIR27B (microRNA 27b)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52571/mir27b