MIR34B (microRNA 34b)

2008-09-01  

Identity

HGNC
MIR34B
LOCATION
11q23.1
LOCUSID
407041
ALIAS
MIRN34B,miRNA34B,mir-34b

Other Information

Locus ID:

NCBI: 407041
MIM: 611374
HGNC: 31636
Ensembl: ENSG00000207811
miRBase:

Variants:

dbSNP: 407041
ClinVar: 407041
TCGA: ENSG00000207811
COSMIC: MIR34B

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
185196712008Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.216
184511452008Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.84
203099402011A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma.65
255414882015Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease.45
235045542013Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma.27
249708122014Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis.27
233052262013MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3.23
248928872014Increased striatal adenosine A2A receptor levels is an early event in Parkinson's disease-related pathology and it is potentially regulated by miR-34b.23
243373712014Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.19
233146122013MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met.17

Citation

Dessen P

MIR34B (microRNA 34b)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50326/mir34b