MIRLET7A2 (microRNA let-7a-2)

2013-08-01  

Identity

HGNC
MIRLET7A2
LOCATION
11q24.1
LOCUSID
406882
ALIAS
LET7A2,MIRNLET7A2,let-7a-2

Other Information

Locus ID:

NCBI: 406882
MIM: 612142
HGNC: 31477
Ensembl: ENSG00000198975
miRBase:

Variants:

dbSNP: 406882
ClinVar: 406882
TCGA: ENSG00000198975
COSMIC: MIRLET7A2

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
297485712018TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.22
252473042014Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries.19
256470782015Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.12
263936822015The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth.10
263482042015USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2.9
255159212015Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells.7
313300672019Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.1
208899072011Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival.0
213652662011Characterization and functional analysis of the human microRNA let-7a2 promoter in lung cancer A549 cell lines.0
2356683420131,25-Dihydroxyvitamin D3 up-regulates expression of hsa-let-7a-2 through the interaction of VDR/VDRE in human lung cancer A549 cells.0

Citation

Dessen P

MIRLET7A2 (microRNA let-7a-2)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53734/mirlet7a2