MIRLET7B (microRNA let-7b)

2012-09-01  

Identity

HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
LET7B,MIRNLET7B,hsa-let-7b,let-7b

Other Information

Locus ID:

NCBI: 406884
MIM: 611249
HGNC: 31479
Ensembl: ENSG00000284520
miRBase:

Variants:

dbSNP: 406884
ClinVar: 406884
TCGA: ENSG00000284520
COSMIC: MIRLET7B

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
226100692012An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.237
201302132010MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response.83
220223552011Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.43
234372182013Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4.39
237989982013Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer.35
249833652014Circulating cell-free cancer-testis MAGE-A RNA, BORIS RNA, let-7b and miR-202 in the blood of patients with breast cancer and benign breast diseases.30
227617382012Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.19
248101132014IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma.19
252473042014Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries.19
256332612015Inhibition of c-Myc by let-7b mimic reverses mutidrug resistance in gastric cancer cells.19

Citation

Dessen P

MIRLET7B (microRNA let-7b)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52864/mirlet7b