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MIS12 (MIS12, kinetochore complex component)

Identity

Alias_namesMIS12, MIND kinetochore complex component, homolog (yeast)
MIS12, MIND kinetochore complex component, homolog (S. pombe)
Alias_symbol (synonym)MGC2488
hMIS12
KNTC2AP
MTW1
Other alias2510025F08Rik
hMis12
HGNC (Hugo) MIS12
LocusID (NCBI) 79003
Atlas_Id 70322
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 5486374 and ends at 5490810 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MIS12   24967
Cards
Entrez_Gene (NCBI)MIS12  79003  MIS12, kinetochore complex component
Aliases2510025F08Rik; KNTC2AP; MTW1; hMis12
GeneCards (Weizmann)MIS12
Ensembl hg19 (Hinxton)ENSG00000167842 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167842 [Gene_View]  chr17:5486374-5490810 [Contig_View]  MIS12 [Vega]
ICGC DataPortalENSG00000167842
TCGA cBioPortalMIS12
AceView (NCBI)MIS12
Genatlas (Paris)MIS12
WikiGenes79003
SOURCE (Princeton)MIS12
Genetics Home Reference (NIH)MIS12
Genomic and cartography
GoldenPath hg38 (UCSC)MIS12  -     chr17:5486374-5490810 +  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIS12  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblMIS12 - 17p13.2 [CytoView hg19]  MIS12 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIMIS12 [Mapview hg19]  MIS12 [Mapview hg38]
OMIM609178   
Gene and transcription
Genbank (Entrez)AK056072 AK289939 AL136906 AM392972 AM393558
RefSeq transcript (Entrez)NM_001258217 NM_001258218 NM_001258219 NM_001258220 NM_024039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MIS12
Cluster EST : UnigeneHs.267194 [ NCBI ]
CGAP (NCI)Hs.267194
Alternative Splicing GalleryENSG00000167842
Gene ExpressionMIS12 [ NCBI-GEO ]   MIS12 [ EBI - ARRAY_EXPRESS ]   MIS12 [ SEEK ]   MIS12 [ MEM ]
Gene Expression Viewer (FireBrowse)MIS12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79003
GTEX Portal (Tissue expression)MIS12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H081
Splice isoforms : SwissVarQ9H081
PhosPhoSitePlusQ9H081
Domains : Interpro (EBI)Centromere_Mis12   
Domain families : Pfam (Sanger)Mis12 (PF05859)   
Domain families : Pfam (NCBI)pfam05859   
Conserved Domain (NCBI)MIS12
DMDM Disease mutations79003
Blocks (Seattle)MIS12
PDB (SRS)5LSJ    5LSK   
PDB (PDBSum)5LSJ    5LSK   
PDB (IMB)5LSJ    5LSK   
PDB (RSDB)5LSJ    5LSK   
Structural Biology KnowledgeBase5LSJ    5LSK   
SCOP (Structural Classification of Proteins)5LSJ    5LSK   
CATH (Classification of proteins structures)5LSJ    5LSK   
SuperfamilyQ9H081
Human Protein AtlasENSG00000167842
Peptide AtlasQ9H081
HPRD12379
IPIIPI00031527   
Protein Interaction databases
DIP (DOE-UCLA)Q9H081
IntAct (EBI)Q9H081
FunCoupENSG00000167842
BioGRIDMIS12
STRING (EMBL)MIS12
ZODIACMIS12
Ontologies - Pathways
QuickGOQ9H081
Ontology : AmiGOMIS12/MIND type complex  protein binding  nucleus  cytosol  chromosome segregation  sister chromatid cohesion  cell division  attachment of mitotic spindle microtubules to kinetochore  kinetochore assembly  
Ontology : EGO-EBIMIS12/MIND type complex  protein binding  nucleus  cytosol  chromosome segregation  sister chromatid cohesion  cell division  attachment of mitotic spindle microtubules to kinetochore  kinetochore assembly  
NDEx NetworkMIS12
Atlas of Cancer Signalling NetworkMIS12
Wikipedia pathwaysMIS12
Orthology - Evolution
OrthoDB79003
GeneTree (enSembl)ENSG00000167842
Phylogenetic Trees/Animal Genes : TreeFamMIS12
HOVERGENQ9H081
HOGENOMQ9H081
Homologs : HomoloGeneMIS12
Homology/Alignments : Family Browser (UCSC)MIS12
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMIS12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MIS12
dbVarMIS12
ClinVarMIS12
1000_GenomesMIS12 
Exome Variant ServerMIS12
ExAC (Exome Aggregation Consortium)MIS12 (select the gene name)
Genetic variants : HAPMAP79003
Genomic Variants (DGV)MIS12 [DGVbeta]
DECIPHERMIS12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMIS12 
Mutations
ICGC Data PortalMIS12 
TCGA Data PortalMIS12 
Broad Tumor PortalMIS12
OASIS PortalMIS12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMIS12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMIS12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MIS12
DgiDB (Drug Gene Interaction Database)MIS12
DoCM (Curated mutations)MIS12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MIS12 (select a term)
intoGenMIS12
Cancer3DMIS12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609178   
Orphanet
MedgenMIS12
Genetic Testing Registry MIS12
NextProtQ9H081 [Medical]
TSGene79003
GENETestsMIS12
Huge Navigator MIS12 [HugePedia]
snp3D : Map Gene to Disease79003
BioCentury BCIQMIS12
ClinGenMIS12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79003
Chemical/Pharm GKB GenePA134951024
Clinical trialMIS12
Miscellaneous
canSAR (ICR)MIS12 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMIS12
EVEXMIS12
GoPubMedMIS12
iHOPMIS12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:43:20 CEST 2017

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