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MKI67 (marker of proliferation Ki-67)

Identity

Other namesKIA
MIB-
MIB-1
PPP1R105
HGNC (Hugo) MKI67
LocusID (NCBI) 4288
Location 10q26.2
Location_base_pair Starts at 129894925 and ends at 129924468 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MKI67   7107
Cards
Entrez_Gene (NCBI)MKI67  4288  marker of proliferation Ki-67
GeneCards (Weizmann)MKI67
Ensembl (Hinxton)ENSG00000148773 [Gene_View]  chr10:129894925-129924468 [Contig_View]  MKI67 [Vega]
ICGC DataPortalENSG00000148773
cBioPortalMKI67
AceView (NCBI)MKI67
Genatlas (Paris)MKI67
WikiGenes4288
SOURCE (Princeton)NM_001145966 NM_002417
Genomic and cartography
GoldenPath (UCSC)MKI67  -  10q26.2   chr10:129894925-129924468 -  10q26.2   [Description]    (hg19-Feb_2009)
EnsemblMKI67 - 10q26.2 [CytoView]
Mapping of homologs : NCBIMKI67 [Mapview]
OMIM176741   
Gene and transcription
Genbank (Entrez)AJ567755 AJ567756 AJ567757 AK299254 BM699306
RefSeq transcript (Entrez)NM_001145966 NM_002417
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NT_030059 NW_001838011 NW_004929377
Consensus coding sequences : CCDS (NCBI)MKI67
Cluster EST : UnigeneHs.689823 [ NCBI ]
CGAP (NCI)Hs.689823
Alternative Splicing : Fast-db (Paris)GSHG0004450
Alternative Splicing GalleryENSG00000148773
Gene ExpressionMKI67 [ NCBI-GEO ]     MKI67 [ SEEK ]   MKI67 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46013 (Uniprot)
NextProtP46013  [Medical]
With graphics : InterProP46013
Splice isoforms : SwissVarP46013 (Swissvar)
Domaine pattern : Prosite (Expaxy)FHA_DOMAIN (PS50006)   
Domains : Interpro (EBI)FHA_dom [organisation]   K167R [organisation]   PP1-bd [organisation]   SMAD_FHA_domain [organisation]  
Related proteins : CluSTrP46013
Domain families : Pfam (Sanger)FHA (PF00498)    K167R (PF08065)    PP1_bind (PF15276)   
Domain families : Pfam (NCBI)pfam00498    pfam08065    pfam15276   
Domain families : Smart (EMBL)FHA (SM00240)  
DMDM Disease mutations4288
Blocks (Seattle)P46013
PDB (SRS)1R21    2AFF   
PDB (PDBSum)1R21    2AFF   
PDB (IMB)1R21    2AFF   
PDB (RSDB)1R21    2AFF   
Human Protein AtlasENSG00000148773 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP46013
HPRD08902
IPIIPI00004233   IPI00413173   IPI00844453   IPI01011955   IPI01012421   IPI00426109   
Protein Interaction databases
DIP (DOE-UCLA)P46013
IntAct (EBI)P46013
FunCoupENSG00000148773
BioGRIDMKI67
InParanoidP46013
Interologous Interaction database P46013
IntegromeDBMKI67
STRING (EMBL)MKI67
Ontologies - Pathways
Ontology : AmiGOchromosome, centromeric region  condensed chromosome  protein binding  ATP binding  nucleus  nucleolus  cytoplasm  DNA metabolic process  meiotic nuclear division  protein C-terminus binding  cell proliferation  response to organic cyclic compound  membrane  hyaluronan metabolic process  organ regeneration  cellular response to heat  poly(A) RNA binding  
Ontology : EGO-EBIchromosome, centromeric region  condensed chromosome  protein binding  ATP binding  nucleus  nucleolus  cytoplasm  DNA metabolic process  meiotic nuclear division  protein C-terminus binding  cell proliferation  response to organic cyclic compound  membrane  hyaluronan metabolic process  organ regeneration  cellular response to heat  poly(A) RNA binding  
Protein Interaction DatabaseMKI67
Wikipedia pathwaysMKI67
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MKI67
snp3D : Map Gene to Disease4288
SNP (GeneSNP Utah)MKI67
SNP : HGBaseMKI67
Genetic variants : HAPMAPMKI67
Exome VariantMKI67
1000_GenomesMKI67 
ICGC programENSG00000148773 
Somatic Mutations in Cancer : COSMICMKI67 
CONAN: Copy Number AnalysisMKI67 
Mutations and Diseases : HGMDMKI67
Genomic VariantsMKI67  MKI67 [DGVbeta]
dbVarMKI67
ClinVarMKI67
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM176741   
MedgenMKI67
GENETestsMKI67
Disease Genetic AssociationMKI67
Huge Navigator MKI67 [HugePedia]  MKI67 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMKI67
Homology/Alignments : Family Browser (UCSC)MKI67
Phylogenetic Trees/Animal Genes : TreeFamMKI67
Chemical/Protein Interactions : CTD4288
Chemical/Pharm GKB GenePA30825
Clinical trialMKI67
Cancer Resource (Charite)ENSG00000148773
Other databases
Probes
Litterature
PubMed434 Pubmed reference(s) in Entrez
CoreMineMKI67
iHOPMKI67
OncoSearchMKI67
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:06:18 CEST 2014

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