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MKNK1 (MAP kinase interacting serine/threonine kinase 1)

Identity

Alias_symbol (synonym)MNK1
Other alias
HGNC (Hugo) MKNK1
LocusID (NCBI) 8569
Atlas_Id 41371
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 47023079 and ends at 47069966 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MKNK1 (1p33) / SHFM1 (7q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MKNK1   7110
Cards
Entrez_Gene (NCBI)MKNK1  8569  MAP kinase interacting serine/threonine kinase 1
AliasesMNK1
GeneCards (Weizmann)MKNK1
Ensembl hg19 (Hinxton)ENSG00000079277 [Gene_View]  chr1:47023079-47069966 [Contig_View]  MKNK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000079277 [Gene_View]  chr1:47023079-47069966 [Contig_View]  MKNK1 [Vega]
ICGC DataPortalENSG00000079277
TCGA cBioPortalMKNK1
AceView (NCBI)MKNK1
Genatlas (Paris)MKNK1
WikiGenes8569
SOURCE (Princeton)MKNK1
Genetics Home Reference (NIH)MKNK1
Genomic and cartography
GoldenPath hg19 (UCSC)MKNK1  -     chr1:47023079-47069966 -  1p33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MKNK1  -     1p33   [Description]    (hg38-Dec_2013)
EnsemblMKNK1 - 1p33 [CytoView hg19]  MKNK1 - 1p33 [CytoView hg38]
Mapping of homologs : NCBIMKNK1 [Mapview hg19]  MKNK1 [Mapview hg38]
OMIM606724   
Gene and transcription
Genbank (Entrez)AB000409 AB451300 AB451432 AK096423 AK290456
RefSeq transcript (Entrez)NM_001135553 NM_003684 NM_198973
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_032029 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)MKNK1
Cluster EST : UnigeneHs.371594 [ NCBI ]
CGAP (NCI)Hs.371594
Alternative Splicing GalleryENSG00000079277
Gene ExpressionMKNK1 [ NCBI-GEO ]   MKNK1 [ EBI - ARRAY_EXPRESS ]   MKNK1 [ SEEK ]   MKNK1 [ MEM ]
Gene Expression Viewer (FireBrowse)MKNK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8569
GTEX Portal (Tissue expression)MKNK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BUB5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BUB5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BUB5
Splice isoforms : SwissVarQ9BUB5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9BUB5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MKNK1
DMDM Disease mutations8569
Blocks (Seattle)MKNK1
PDB (SRS)2HW6    2Y9Q   
PDB (PDBSum)2HW6    2Y9Q   
PDB (IMB)2HW6    2Y9Q   
PDB (RSDB)2HW6    2Y9Q   
Structural Biology KnowledgeBase2HW6    2Y9Q   
SCOP (Structural Classification of Proteins)2HW6    2Y9Q   
CATH (Classification of proteins structures)2HW6    2Y9Q   
SuperfamilyQ9BUB5
Human Protein AtlasENSG00000079277
Peptide AtlasQ9BUB5
HPRD09468
IPIIPI00304048   IPI00187091   IPI00412417   IPI00979517   IPI00981835   IPI01014049   IPI00384906   IPI00514270   IPI00984731   IPI00976436   IPI00983527   IPI01015795   IPI00975786   IPI00978291   IPI00977564   IPI00984219   IPI00980028   
Protein Interaction databases
DIP (DOE-UCLA)Q9BUB5
IntAct (EBI)Q9BUB5
FunCoupENSG00000079277
BioGRIDMKNK1
STRING (EMBL)MKNK1
ZODIACMKNK1
Ontologies - Pathways
QuickGOQ9BUB5
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of translational initiation  protein phosphorylation  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  intracellular signal transduction  protein autophosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of translational initiation  protein phosphorylation  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  intracellular signal transduction  protein autophosphorylation  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]    p38 MAPK Signaling Pathway [Genes]    mTOR Signaling Pathway [Genes]    Regulation of eIF4e and p70 S6 Kinase [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    HIF-1 signaling pathway    Insulin signaling pathway   
NDEx NetworkMKNK1
Atlas of Cancer Signalling NetworkMKNK1
Wikipedia pathwaysMKNK1
Orthology - Evolution
OrthoDB8569
GeneTree (enSembl)ENSG00000079277
Phylogenetic Trees/Animal Genes : TreeFamMKNK1
HOVERGENQ9BUB5
HOGENOMQ9BUB5
Homologs : HomoloGeneMKNK1
Homology/Alignments : Family Browser (UCSC)MKNK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMKNK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MKNK1
dbVarMKNK1
ClinVarMKNK1
1000_GenomesMKNK1 
Exome Variant ServerMKNK1
ExAC (Exome Aggregation Consortium)MKNK1 (select the gene name)
Genetic variants : HAPMAP8569
Genomic Variants (DGV)MKNK1 [DGVbeta]
DECIPHER (Syndromes)1:47023079-47069966  ENSG00000079277
CONAN: Copy Number AnalysisMKNK1 
Mutations
ICGC Data PortalMKNK1 
TCGA Data PortalMKNK1 
Broad Tumor PortalMKNK1
OASIS PortalMKNK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMKNK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMKNK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MKNK1
DgiDB (Drug Gene Interaction Database)MKNK1
DoCM (Curated mutations)MKNK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MKNK1 (select a term)
intoGenMKNK1
Cancer3DMKNK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606724   
Orphanet
MedgenMKNK1
Genetic Testing Registry MKNK1
NextProtQ9BUB5 [Medical]
TSGene8569
GENETestsMKNK1
Huge Navigator MKNK1 [HugePedia]
snp3D : Map Gene to Disease8569
BioCentury BCIQMKNK1
ClinGenMKNK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8569
Chemical/Pharm GKB GenePA30829
Clinical trialMKNK1
Miscellaneous
canSAR (ICR)MKNK1 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMKNK1
EVEXMKNK1
GoPubMedMKNK1
iHOPMKNK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:10:45 CEST 2017

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