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MKNK2 (MAP kinase interacting serine/threonine kinase 2)

Identity

Alias_namesGPRK7
G protein-coupled receptor kinase 7
Alias_symbol (synonym)MNK2
Other alias
HGNC (Hugo) MKNK2
LocusID (NCBI) 2872
Atlas_Id 41372
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2037471 and ends at 2051244 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNK1 (1q42.2) / MKNK2 (19p13.3)MKNK2 (19p13.3) / AP3D1 (19p13.3)MKNK2 (19p13.3) / FAM151A (1p32.3)
MKNK2 (19p13.3) / GNG7 (19p13.3)MKNK2 (19p13.3) / RNF126 (19p13.3)MKNK2 (19p13.3) / ZFR2 (19p13.3)
MKNK2 19p13.3 / FAM151A 1p32.3MKNK2 19p13.3 / RNF126 19p13.3MKNK2 19p13.3 / ZFR2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MKNK2   7111
Cards
Entrez_Gene (NCBI)MKNK2  2872  MAP kinase interacting serine/threonine kinase 2
AliasesGPRK7; MNK2
GeneCards (Weizmann)MKNK2
Ensembl hg19 (Hinxton)ENSG00000099875 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099875 [Gene_View]  chr19:2037471-2051244 [Contig_View]  MKNK2 [Vega]
ICGC DataPortalENSG00000099875
TCGA cBioPortalMKNK2
AceView (NCBI)ci?db=human&term=MKNK2&submit=Go TARGET=AceView>MKNK2
Genatlas (Paris)MKNK2
WikiGenes2872
SOURCE (Princeton)MKNK2
Genetics Home Reference (NIH)MKNK2
Genomic and cartography
GoldenPath hg38 (UCSC)MKNK2  -     chr19:2037471-2051244 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MKNK2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblMKNK2 - 19p13.3 [CytoView hg19]  MKNK2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIMKNK2 [Mapview hg19]  MKNK2 [Mapview hg38]
OMIM605069   
Gene and transcription
Genbank (Entrez)AB209074 AF125532 AF237775 AF237776 AK001730
RefSeq transcript (Entrez)NM_017572 NM_199054
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MKNK2
Cluster EST : UnigeneHs.515032 [ NCBI ]
CGAP (NCI)Hs.515032
Alternative Splicing GalleryENSG00000099875
Gene ExpressionMKNK2 [ NCBI-GEO ]   MKNK2 [ EBI - ARRAY_EXPRESS ]   MKNK2 [ SEEK ]   MKNK2 [ MEM ]
Gene Expression Viewer (FireBrowse)MKNK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2872
GTEX Portal (Tissue expression)MKNK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBH9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBH9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBH9
Splice isoforms : SwissVarQ9HBH9
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9HBH9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MKNK2
DMDM Disease mutations2872
Blocks (Seattle)MKNK2
PDB (SRS)2AC3    2AC5    2HW7   
PDB (PDBSum)2AC3    2AC5    2HW7   
PDB (IMB)2AC3    2AC5    2HW7   
PDB (RSDB)2AC3    2AC5    2HW7   
Structural Biology KnowledgeBase2AC3    2AC5    2HW7   
SCOP (Structural Classification of Proteins)2AC3    2AC5    2HW7   
CATH (Classification of proteins structures)2AC3    2AC5    2HW7   
SuperfamilyQ9HBH9
Human Protein AtlasENSG00000099875
Peptide AtlasQ9HBH9
HPRD05459
IPIIPI00396114   IPI00479444   IPI01015106   IPI01010235   IPI00556585   IPI00744662   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBH9
IntAct (EBI)Q9HBH9
FunCoupENSG00000099875
BioGRIDMKNK2
STRING (EMBL)MKNK2
ZODIACMKNK2
Ontologies - Pathways
QuickGOQ9HBH9
Ontology : AmiGOprotein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleus  nucleolus  cytoplasm  regulation of translation  protein phosphorylation  cell surface receptor signaling pathway  calcium-dependent protein serine/threonine kinase activity  nuclear body  PML body  peptidyl-serine phosphorylation  hemopoiesis  intracellular signal transduction  protein autophosphorylation  metal ion binding  cellular response to arsenic-containing substance  extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIprotein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleus  nucleolus  cytoplasm  regulation of translation  protein phosphorylation  cell surface receptor signaling pathway  calcium-dependent protein serine/threonine kinase activity  nuclear body  PML body  peptidyl-serine phosphorylation  hemopoiesis  intracellular signal transduction  protein autophosphorylation  metal ion binding  cellular response to arsenic-containing substance  extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAErk1/Erk2 Mapk Signaling pathway [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    HIF-1 signaling pathway    Insulin signaling pathway   
NDEx NetworkMKNK2
Atlas of Cancer Signalling NetworkMKNK2
Wikipedia pathwaysMKNK2
Orthology - Evolution
OrthoDB2872
GeneTree (enSembl)ENSG00000099875
Phylogenetic Trees/Animal Genes : TreeFamMKNK2
HOVERGENQ9HBH9
HOGENOMQ9HBH9
Homologs : HomoloGeneMKNK2
Homology/Alignments : Family Browser (UCSC)MKNK2
Gene fusions - Rearrangements
Fusion : MitelmanMKNK2/FAM151A [19p13.3/1p32.3]  
Fusion : MitelmanMKNK2/RNF126 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanMKNK2/ZFR2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAMKNK2 19p13.3 FAM151A 1p32.3 BRCA
Fusion: TCGAMKNK2 19p13.3 RNF126 19p13.3 LAML
Fusion: TCGAMKNK2 19p13.3 ZFR2 19p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMKNK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MKNK2
dbVarMKNK2
ClinVarMKNK2
1000_GenomesMKNK2 
Exome Variant ServerMKNK2
ExAC (Exome Aggregation Consortium)MKNK2 (select the gene name)
Genetic variants : HAPMAP2872
Genomic Variants (DGV)MKNK2 [DGVbeta]
DECIPHERMKNK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMKNK2 
Mutations
ICGC Data PortalMKNK2 
TCGA Data PortalMKNK2 
Broad Tumor PortalMKNK2
OASIS PortalMKNK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMKNK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMKNK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MKNK2
DgiDB (Drug Gene Interaction Database)MKNK2
DoCM (Curated mutations)MKNK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MKNK2 (select a term)
intoGenMKNK2
Cancer3DMKNK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605069   
Orphanet
MedgenMKNK2
Genetic Testing Registry MKNK2
NextProtQ9HBH9 [Medical]
TSGene2872
GENETestsMKNK2
Target ValidationMKNK2
Huge Navigator MKNK2 [HugePedia]
snp3D : Map Gene to Disease2872
BioCentury BCIQMKNK2
ClinGenMKNK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2872
Chemical/Pharm GKB GenePA30830
Clinical trialMKNK2
Miscellaneous
canSAR (ICR)MKNK2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMKNK2
EVEXMKNK2
GoPubMedMKNK2
iHOPMKNK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:00:27 CEST 2017

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