MKNK2 (MAPK interacting serine/threonine kinase 2)

2003-11-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
GPRK7,MNK2
FUSION GENES

Other Information

Locus ID:

NCBI: 2872
MIM: 605069
HGNC: 7111
Ensembl: ENSG00000099875

Variants:

dbSNP: 2872
ClinVar: 2872
TCGA: ENSG00000099875
COSMIC: MKNK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099875ENST00000250896Q9HBH9
ENSG00000099875ENST00000586828K7EK27
ENSG00000099875ENST00000588014K7EJ98
ENSG00000099875ENST00000589441K7EMP5
ENSG00000099875ENST00000589509K7ELN0
ENSG00000099875ENST00000589534K7ELG3
ENSG00000099875ENST00000591142Q9NV89
ENSG00000099875ENST00000591588K7EIN7
ENSG00000099875ENST00000591601Q9HBH9

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Insulin signaling pathwayKEGGko04910
MAPK signaling pathwayKEGGhsa04010
Insulin signaling pathwayKEGGhsa04910
HIF-1 signaling pathwayKEGGhsa04066

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
261476852015Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.70
227970672013Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.42
128971412003The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.35
254032302014MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.27
251938632014Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells.20
211494472011Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.19
255274532015Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.15
276183662016Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.12
238140522013Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.11
303290872018Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.6

Citation

Dessen P

MKNK2 (MAPK interacting serine/threonine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41372/mknk2