Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MKRN1 (makorin ring finger protein 1)

Identity

Alias_symbol (synonym)RNF61
Other alias
HGNC (Hugo) MKRN1
LocusID (NCBI) 23608
Atlas_Id 51299
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 140155983 and ends at 140179369 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MKRN1 (7q34) / BRAF (7q34)MKRN1 (7q34) / DENND2A (7q34)MKRN1 (7q34) / GDA (9q21.13)
MKRN1 (7q34) / MKRN1 (7q34)MKRN1 (7q34) / MRPS33 (7q34)MKRN1 7q34 / BRAF 7q34
MKRN1 7q34 / DENND2A 7q34MKRN1 7q34 / MRPS33 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MKRN1   7112
Cards
Entrez_Gene (NCBI)MKRN1  23608  makorin ring finger protein 1
AliasesRNF61
GeneCards (Weizmann)MKRN1
Ensembl hg19 (Hinxton)ENSG00000133606 [Gene_View]  chr7:140155983-140179369 [Contig_View]  MKRN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133606 [Gene_View]  chr7:140155983-140179369 [Contig_View]  MKRN1 [Vega]
ICGC DataPortalENSG00000133606
TCGA cBioPortalMKRN1
AceView (NCBI)MKRN1
Genatlas (Paris)MKRN1
WikiGenes23608
SOURCE (Princeton)MKRN1
Genetics Home Reference (NIH)MKRN1
Genomic and cartography
GoldenPath hg19 (UCSC)MKRN1  -     chr7:140155983-140179369 -  7q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MKRN1  -     7q34   [Description]    (hg38-Dec_2013)
EnsemblMKRN1 - 7q34 [CytoView hg19]  MKRN1 - 7q34 [CytoView hg38]
Mapping of homologs : NCBIMKRN1 [Mapview hg19]  MKRN1 [Mapview hg38]
OMIM607754   
Gene and transcription
Genbank (Entrez)AB209298 AF117233 AF192784 AI828363 AK024987
RefSeq transcript (Entrez)NM_001145125 NM_001291663 NM_013446
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)MKRN1
Cluster EST : UnigeneHs.744883 [ NCBI ]
CGAP (NCI)Hs.744883
Alternative Splicing GalleryENSG00000133606
Gene ExpressionMKRN1 [ NCBI-GEO ]   MKRN1 [ EBI - ARRAY_EXPRESS ]   MKRN1 [ SEEK ]   MKRN1 [ MEM ]
Gene Expression Viewer (FireBrowse)MKRN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23608
GTEX Portal (Tissue expression)MKRN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHC7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHC7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHC7
Splice isoforms : SwissVarQ9UHC7
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ9UHC7
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)MKRN1_C    Znf_C3HC4_RING-type    Znf_CCCH    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)MKRN1_C (PF15815)    zf-C3HC4 (PF00097)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam15815    pfam00097    pfam00642   
Domain families : Smart (EMBL)RING (SM00184)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)MKRN1
DMDM Disease mutations23608
Blocks (Seattle)MKRN1
SuperfamilyQ9UHC7
Human Protein AtlasENSG00000133606
Peptide AtlasQ9UHC7
HPRD09673
IPIIPI00033350   IPI00946774   IPI00973591   IPI00921845   IPI01015445   IPI00945768   IPI00947318   IPI00946335   IPI00947035   IPI00947551   IPI00947058   IPI00946491   IPI00944929   IPI00945351   IPI00947187   IPI00946589   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHC7
IntAct (EBI)Q9UHC7
FunCoupENSG00000133606
BioGRIDMKRN1
STRING (EMBL)MKRN1
ZODIACMKRN1
Ontologies - Pathways
QuickGOQ9UHC7
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  protein binding  cellular_component  zinc ion binding  ligase activity  poly(A) RNA binding  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  protein binding  cellular_component  zinc ion binding  ligase activity  poly(A) RNA binding  
NDEx NetworkMKRN1
Atlas of Cancer Signalling NetworkMKRN1
Wikipedia pathwaysMKRN1
Orthology - Evolution
OrthoDB23608
GeneTree (enSembl)ENSG00000133606
Phylogenetic Trees/Animal Genes : TreeFamMKRN1
HOVERGENQ9UHC7
HOGENOMQ9UHC7
Homologs : HomoloGeneMKRN1
Homology/Alignments : Family Browser (UCSC)MKRN1
Gene fusions - Rearrangements
Fusion: TCGAMKRN1 7q34 BRAF 7q34 THCA
Fusion: TCGAMKRN1 7q34 DENND2A 7q34 LGG
Fusion: TCGAMKRN1 7q34 MRPS33 7q34 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMKRN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MKRN1
dbVarMKRN1
ClinVarMKRN1
1000_GenomesMKRN1 
Exome Variant ServerMKRN1
ExAC (Exome Aggregation Consortium)MKRN1 (select the gene name)
Genetic variants : HAPMAP23608
Genomic Variants (DGV)MKRN1 [DGVbeta]
DECIPHER (Syndromes)7:140155983-140179369  ENSG00000133606
CONAN: Copy Number AnalysisMKRN1 
Mutations
ICGC Data PortalMKRN1 
TCGA Data PortalMKRN1 
Broad Tumor PortalMKRN1
OASIS PortalMKRN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMKRN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMKRN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MKRN1
DgiDB (Drug Gene Interaction Database)MKRN1
DoCM (Curated mutations)MKRN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MKRN1 (select a term)
intoGenMKRN1
Cancer3DMKRN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607754   
Orphanet
MedgenMKRN1
Genetic Testing Registry MKRN1
NextProtQ9UHC7 [Medical]
TSGene23608
GENETestsMKRN1
Huge Navigator MKRN1 [HugePedia]
snp3D : Map Gene to Disease23608
BioCentury BCIQMKRN1
ClinGenMKRN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23608
Chemical/Pharm GKB GenePA30831
Clinical trialMKRN1
Miscellaneous
canSAR (ICR)MKRN1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMKRN1
EVEXMKRN1
GoPubMedMKRN1
iHOPMKRN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:10:45 CEST 2017

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