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MKRN2 (makorin ring finger protein 2)

Identity

Alias_symbol (synonym)RNF62
HSPC070
Other alias
HGNC (Hugo) MKRN2
LocusID (NCBI) 23609
Atlas_Id 56213
Location 3p25.2  [Link to chromosome band 3p25]
Location_base_pair Starts at 12557014 and ends at 12583711 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ESRP1 (8q22.1) / MKRN2 (3p25.2)MKRN2 (3p25.2) / CCDC191 (3q13.31)NSMCE2 (8q24.13) / MKRN2 (3p25.2)
PCNP (3q12.3) / MKRN2 (3p25.2)PRKCDBP (11p15.4) / MKRN2 (3p25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MKRN2   7113
Cards
Entrez_Gene (NCBI)MKRN2  23609  makorin ring finger protein 2
AliasesHSPC070; RNF62
GeneCards (Weizmann)MKRN2
Ensembl hg19 (Hinxton)ENSG00000075975 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075975 [Gene_View]  chr3:12557014-12583711 [Contig_View]  MKRN2 [Vega]
ICGC DataPortalENSG00000075975
TCGA cBioPortalMKRN2
AceView (NCBI)MKRN2
Genatlas (Paris)MKRN2
WikiGenes23609
SOURCE (Princeton)MKRN2
Genetics Home Reference (NIH)MKRN2
Genomic and cartography
GoldenPath hg38 (UCSC)MKRN2  -     chr3:12557014-12583711 +  3p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MKRN2  -     3p25.2   [Description]    (hg19-Feb_2009)
EnsemblMKRN2 - 3p25.2 [CytoView hg19]  MKRN2 - 3p25.2 [CytoView hg38]
Mapping of homologs : NCBIMKRN2 [Mapview hg19]  MKRN2 [Mapview hg38]
OMIM608426   
Gene and transcription
Genbank (Entrez)AF302084 AK091318 AK298463 AL834512 BC001799
RefSeq transcript (Entrez)NM_001271707 NM_014160
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MKRN2
Cluster EST : UnigeneHs.591666 [ NCBI ]
CGAP (NCI)Hs.591666
Alternative Splicing GalleryENSG00000075975
Gene ExpressionMKRN2 [ NCBI-GEO ]   MKRN2 [ EBI - ARRAY_EXPRESS ]   MKRN2 [ SEEK ]   MKRN2 [ MEM ]
Gene Expression Viewer (FireBrowse)MKRN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23609
GTEX Portal (Tissue expression)MKRN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H000   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H000  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H000
Splice isoforms : SwissVarQ9H000
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ9H000
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Makorin_2    Znf_C3HC4_RING-type    Znf_CCCH    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-C3HC4 (PF00097)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00097    pfam00642   
Domain families : Smart (EMBL)RING (SM00184)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)MKRN2
DMDM Disease mutations23609
Blocks (Seattle)MKRN2
SuperfamilyQ9H000
Human Protein AtlasENSG00000075975
Peptide AtlasQ9H000
HPRD09761
IPIIPI00396406   IPI00927374   IPI00927618   
Protein Interaction databases
DIP (DOE-UCLA)Q9H000
IntAct (EBI)Q9H000
FunCoupENSG00000075975
BioGRIDMKRN2
STRING (EMBL)MKRN2
ZODIACMKRN2
Ontologies - Pathways
QuickGOQ9H000
Ontology : AmiGORNA binding  protein binding  intracellular  biological_process  zinc ion binding  protein ubiquitination  transferase activity  
Ontology : EGO-EBIRNA binding  protein binding  intracellular  biological_process  zinc ion binding  protein ubiquitination  transferase activity  
NDEx NetworkMKRN2
Atlas of Cancer Signalling NetworkMKRN2
Wikipedia pathwaysMKRN2
Orthology - Evolution
OrthoDB23609
GeneTree (enSembl)ENSG00000075975
Phylogenetic Trees/Animal Genes : TreeFamMKRN2
HOVERGENQ9H000
HOGENOMQ9H000
Homologs : HomoloGeneMKRN2
Homology/Alignments : Family Browser (UCSC)MKRN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMKRN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MKRN2
dbVarMKRN2
ClinVarMKRN2
1000_GenomesMKRN2 
Exome Variant ServerMKRN2
ExAC (Exome Aggregation Consortium)MKRN2 (select the gene name)
Genetic variants : HAPMAP23609
Genomic Variants (DGV)MKRN2 [DGVbeta]
DECIPHERMKRN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMKRN2 
Mutations
ICGC Data PortalMKRN2 
TCGA Data PortalMKRN2 
Broad Tumor PortalMKRN2
OASIS PortalMKRN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMKRN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMKRN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MKRN2
DgiDB (Drug Gene Interaction Database)MKRN2
DoCM (Curated mutations)MKRN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MKRN2 (select a term)
intoGenMKRN2
Cancer3DMKRN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608426   
Orphanet
MedgenMKRN2
Genetic Testing Registry MKRN2
NextProtQ9H000 [Medical]
TSGene23609
GENETestsMKRN2
Huge Navigator MKRN2 [HugePedia]
snp3D : Map Gene to Disease23609
BioCentury BCIQMKRN2
ClinGenMKRN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23609
Chemical/Pharm GKB GenePA30832
Clinical trialMKRN2
Miscellaneous
canSAR (ICR)MKRN2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMKRN2
EVEXMKRN2
GoPubMedMKRN2
iHOPMKRN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:26:50 CEST 2017

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