Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MLC1 (modulator of VRAC current 1)

Identity

Alias (NCBI)LVM
MLC
VL
HGNC (Hugo) MLC1
HGNC Alias symbMLC
KIAA0027
LVM
VL
LocusID (NCBI) 23209
Atlas_Id 70337
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50059391 and ends at 50085352 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRD1 (22q13.33) / MLC1 (22q13.33)PRDX5 (11q13.1) / MLC1 (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  BRD1/MLC1 (22q13)

External links

Nomenclature
HGNC (Hugo)MLC1   17082
Cards
Entrez_Gene (NCBI)MLC1    modulator of VRAC current 1
AliasesLVM; MLC; VL
GeneCards (Weizmann)MLC1
Ensembl hg19 (Hinxton)ENSG00000100427 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100427 [Gene_View]  ENSG00000100427 [Sequence]  chr22:50059391-50085352 [Contig_View]  MLC1 [Vega]
ICGC DataPortalENSG00000100427
TCGA cBioPortalMLC1
AceView (NCBI)MLC1
Genatlas (Paris)MLC1
SOURCE (Princeton)MLC1
Genetics Home Reference (NIH)MLC1
Genomic and cartography
GoldenPath hg38 (UCSC)MLC1  -     chr22:50059391-50085352 -  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLC1  -     22q13.33   [Description]    (hg19-Feb_2009)
GoldenPathMLC1 - 22q13.33 [CytoView hg19]  MLC1 - 22q13.33 [CytoView hg38]
ImmunoBaseENSG00000100427
genome Data Viewer NCBIMLC1 [Mapview hg19]  
OMIM604004   605908   
Gene and transcription
Genbank (Entrez)AF319633 AK124264 AK294048 AK295106 AK297341
RefSeq transcript (Entrez)NM_001376472 NM_001376473 NM_001376474 NM_001376475 NM_001376476 NM_001376477 NM_001376478 NM_001376479 NM_001376480 NM_001376481 NM_001376482 NM_001376483 NM_001376484 NM_015166 NM_139202
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MLC1
Alternative Splicing GalleryENSG00000100427
Gene ExpressionMLC1 [ NCBI-GEO ]   MLC1 [ EBI - ARRAY_EXPRESS ]   MLC1 [ SEEK ]   MLC1 [ MEM ]
Gene Expression Viewer (FireBrowse)MLC1 [ Firebrowse - Broad ]
GenevisibleExpression of MLC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23209
GTEX Portal (Tissue expression)MLC1
Human Protein AtlasENSG00000100427-MLC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15049   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15049  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15049
Splice isoforms : SwissVarQ15049
PhosPhoSitePlusQ15049
Domains : Interpro (EBI)Membrane_MLC1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MLC1
Blocks (Seattle)MLC1
SuperfamilyQ15049
Human Protein Atlas [tissue]ENSG00000100427-MLC1 [tissue]
Peptide AtlasQ15049
HPRD05800
IPIIPI00014240   IPI01013055   IPI01013946   IPI00793010   IPI00922225   
Protein Interaction databases
DIP (DOE-UCLA)Q15049
IntAct (EBI)Q15049
BioGRIDMLC1
STRING (EMBL)MLC1
ZODIACMLC1
Ontologies - Pathways
QuickGOQ15049
Ontology : AmiGOprotein binding  cytoplasm  lysosome  endosome  early endosome  endoplasmic reticulum  endoplasmic reticulum  plasma membrane  plasma membrane  caveola  cell-cell junction  ion transport  protein transport  integral component of membrane  vesicle-mediated transport  basolateral plasma membrane  apical plasma membrane  clathrin-coated vesicle  cytoplasmic vesicle  cytoplasmic vesicle  positive regulation of intracellular transport  protein-containing complex binding  membrane raft  regulation of response to osmotic stress  regulation of response to osmotic stress  perinuclear region of cytoplasm  protein complex oligomerization  recycling endosome  cellular response to cholesterol  caveolin-mediated endocytosis  
Ontology : EGO-EBIprotein binding  cytoplasm  lysosome  endosome  early endosome  endoplasmic reticulum  endoplasmic reticulum  plasma membrane  plasma membrane  caveola  cell-cell junction  ion transport  protein transport  integral component of membrane  vesicle-mediated transport  basolateral plasma membrane  apical plasma membrane  clathrin-coated vesicle  cytoplasmic vesicle  cytoplasmic vesicle  positive regulation of intracellular transport  protein-containing complex binding  membrane raft  regulation of response to osmotic stress  regulation of response to osmotic stress  perinuclear region of cytoplasm  protein complex oligomerization  recycling endosome  cellular response to cholesterol  caveolin-mediated endocytosis  
NDEx NetworkMLC1
Atlas of Cancer Signalling NetworkMLC1
Wikipedia pathwaysMLC1
Orthology - Evolution
OrthoDB23209
GeneTree (enSembl)ENSG00000100427
Phylogenetic Trees/Animal Genes : TreeFamMLC1
HOGENOMQ15049
Homologs : HomoloGeneMLC1
Homology/Alignments : Family Browser (UCSC)MLC1
Gene fusions - Rearrangements
Fusion : QuiverMLC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLC1 [hg38]
dbVarMLC1
ClinVarMLC1
MonarchMLC1
1000_GenomesMLC1 
Exome Variant ServerMLC1
GNOMAD BrowserENSG00000100427
Varsome BrowserMLC1
Genomic Variants (DGV)MLC1 [DGVbeta]
DECIPHERMLC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLC1 
Mutations
ICGC Data PortalMLC1 
TCGA Data PortalMLC1 
Broad Tumor PortalMLC1
OASIS PortalMLC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMLC1
Mutations and Diseases : HGMDMLC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch MLC1
DgiDB (Drug Gene Interaction Database)MLC1
DoCM (Curated mutations)MLC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLC1 (select a term)
intoGenMLC1
Cancer3DMLC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604004    605908   
Orphanet3715   
DisGeNETMLC1
MedgenMLC1
Genetic Testing Registry MLC1
NextProtQ15049 [Medical]
GENETestsMLC1
Target ValidationMLC1
Huge Navigator MLC1 [HugePedia]
ClinGenMLC1
Clinical trials, drugs, therapy
MyCancerGenomeMLC1
Protein Interactions : CTD
Pharm GKB GenePA38199
Clinical trialMLC1
Miscellaneous
canSAR (ICR)MLC1 (select the gene name)
HarmonizomeMLC1
DataMed IndexMLC1
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLC1
EVEXMLC1
GoPubMedMLC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:17:37 CET 2020
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