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MLEC (malectin)

Identity

Alias_namesKIAA0152
KIAA0152
Other alias
HGNC (Hugo) MLEC
LocusID (NCBI) 9761
Atlas_Id 70338
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 120688310 and ends at 120701864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MLEC (12q24.31) / FAM107B (10p13)MLEC (12q24.31) / MAGI1 (3p14.1)MLEC (12q24.31) / MLEC (12q24.31)
MOB3B (9p21.2) / MLEC (12q24.31)MUC5B (11p15.5) / MLEC (12q24.31)TERF1 (8q21.11) / MLEC (12q24.31)
TXNDC9 (2q11.2) / MLEC (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;3)(p36;q21) RPN1/PRDM16


External links

Nomenclature
HGNC (Hugo)MLEC   28973
Cards
Entrez_Gene (NCBI)MLEC  9761  malectin
AliasesKIAA0152
GeneCards (Weizmann)MLEC
Ensembl hg19 (Hinxton)ENSG00000110917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110917 [Gene_View]  chr12:120688310-120701864 [Contig_View]  MLEC [Vega]
ICGC DataPortalENSG00000110917
TCGA cBioPortalMLEC
AceView (NCBI)MLEC
Genatlas (Paris)MLEC
WikiGenes9761
SOURCE (Princeton)MLEC
Genetics Home Reference (NIH)MLEC
Genomic and cartography
GoldenPath hg38 (UCSC)MLEC  -     chr12:120688310-120701864 +  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLEC  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblMLEC - 12q24.31 [CytoView hg19]  MLEC - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIMLEC [Mapview hg19]  MLEC [Mapview hg38]
OMIM613802   
Gene and transcription
Genbank (Entrez)AA831396 AK124275 BC000371 BC016297 BE326824
RefSeq transcript (Entrez)NM_001303627 NM_001303628 NM_014730
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MLEC
Cluster EST : UnigeneHs.744910 [ NCBI ]
CGAP (NCI)Hs.744910
Alternative Splicing GalleryENSG00000110917
Gene ExpressionMLEC [ NCBI-GEO ]   MLEC [ EBI - ARRAY_EXPRESS ]   MLEC [ SEEK ]   MLEC [ MEM ]
Gene Expression Viewer (FireBrowse)MLEC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9761
GTEX Portal (Tissue expression)MLEC
Human Protein AtlasENSG00000110917-MLEC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14165   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14165  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14165
Splice isoforms : SwissVarQ14165
PhosPhoSitePlusQ14165
Domains : Interpro (EBI)Malectin   
Domain families : Pfam (Sanger)Malectin (PF11721)   
Domain families : Pfam (NCBI)pfam11721   
Conserved Domain (NCBI)MLEC
DMDM Disease mutations9761
Blocks (Seattle)MLEC
SuperfamilyQ14165
Human Protein Atlas [tissue]ENSG00000110917-MLEC [tissue]
Peptide AtlasQ14165
HPRD13781
IPIIPI00029046   IPI01012626   IPI01009959   IPI01010337   
Protein Interaction databases
DIP (DOE-UCLA)Q14165
IntAct (EBI)Q14165
FunCoupENSG00000110917
BioGRIDMLEC
STRING (EMBL)MLEC
ZODIACMLEC
Ontologies - Pathways
QuickGOQ14165
Ontology : AmiGOendoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  carbohydrate metabolic process  protein folding  membrane  integral component of membrane  enzyme binding  carbohydrate binding  specific granule membrane  neutrophil degranulation  
Ontology : EGO-EBIendoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  carbohydrate metabolic process  protein folding  membrane  integral component of membrane  enzyme binding  carbohydrate binding  specific granule membrane  neutrophil degranulation  
NDEx NetworkMLEC
Atlas of Cancer Signalling NetworkMLEC
Wikipedia pathwaysMLEC
Orthology - Evolution
OrthoDB9761
GeneTree (enSembl)ENSG00000110917
Phylogenetic Trees/Animal Genes : TreeFamMLEC
HOVERGENQ14165
HOGENOMQ14165
Homologs : HomoloGeneMLEC
Homology/Alignments : Family Browser (UCSC)MLEC
Gene fusions - Rearrangements
Fusion: Tumor Portal MLEC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLEC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLEC
dbVarMLEC
ClinVarMLEC
1000_GenomesMLEC 
Exome Variant ServerMLEC
ExAC (Exome Aggregation Consortium)ENSG00000110917
GNOMAD BrowserENSG00000110917
Genetic variants : HAPMAP9761
Genomic Variants (DGV)MLEC [DGVbeta]
DECIPHERMLEC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLEC 
Mutations
ICGC Data PortalMLEC 
TCGA Data PortalMLEC 
Broad Tumor PortalMLEC
OASIS PortalMLEC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLEC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMLEC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MLEC
DgiDB (Drug Gene Interaction Database)MLEC
DoCM (Curated mutations)MLEC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLEC (select a term)
intoGenMLEC
Cancer3DMLEC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613802   
Orphanet
MedgenMLEC
Genetic Testing Registry MLEC
NextProtQ14165 [Medical]
TSGene9761
GENETestsMLEC
Target ValidationMLEC
Huge Navigator MLEC [HugePedia]
snp3D : Map Gene to Disease9761
BioCentury BCIQMLEC
ClinGenMLEC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9761
Chemical/Pharm GKB GenePA164723038
Clinical trialMLEC
Miscellaneous
canSAR (ICR)MLEC (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLEC
EVEXMLEC
GoPubMedMLEC
iHOPMLEC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:17:27 CET 2017

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