Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MLKL (mixed lineage kinase domain like pseudokinase)

Identity

Alias_namesmixed lineage kinase domain-like
Alias_symbol (synonym)FLJ34389
Other aliashMLKL
HGNC (Hugo) MLKL
LocusID (NCBI) 197259
Atlas_Id 43362
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 74671855 and ends at 74701148 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MLKL (16q23.1) / QSOX1 (1q25.2)TLE3 (15q23) / MLKL (16q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MLKL   26617
Cards
Entrez_Gene (NCBI)MLKL  197259  mixed lineage kinase domain like pseudokinase
AliaseshMLKL
GeneCards (Weizmann)MLKL
Ensembl hg19 (Hinxton)ENSG00000168404 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168404 [Gene_View]  ENSG00000168404 [Sequence]  chr16:74671855-74701148 [Contig_View]  MLKL [Vega]
ICGC DataPortalENSG00000168404
TCGA cBioPortalMLKL
AceView (NCBI)MLKL
Genatlas (Paris)MLKL
WikiGenes197259
SOURCE (Princeton)MLKL
Genetics Home Reference (NIH)MLKL
Genomic and cartography
GoldenPath hg38 (UCSC)MLKL  -     chr16:74671855-74701148 -  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLKL  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblMLKL - 14q24.3 [CytoView hg19]  MLKL - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIMLKL [Mapview hg19]  MLKL [Mapview hg38]
OMIM615153   
Gene and transcription
Genbank (Entrez)AK091708 AK093013 AK122998 AL833362 BC028141
RefSeq transcript (Entrez)NM_001142497 NM_152649
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MLKL
Cluster EST : UnigeneHs.119878 [ NCBI ]
CGAP (NCI)Hs.119878
Alternative Splicing GalleryENSG00000168404
Gene ExpressionMLKL [ NCBI-GEO ]   MLKL [ EBI - ARRAY_EXPRESS ]   MLKL [ SEEK ]   MLKL [ MEM ]
Gene Expression Viewer (FireBrowse)MLKL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)197259
GTEX Portal (Tissue expression)MLKL
Human Protein AtlasENSG00000168404-MLKL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NB16   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NB16  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NB16
Splice isoforms : SwissVarQ8NB16
PhosPhoSitePlusQ8NB16
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Adaptor_Cbl_N_dom_sf    Kinase-like_dom_sf    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)MLKL
DMDM Disease mutations197259
Blocks (Seattle)MLKL
PDB (SRS)2MSV    4M67    4MWI    5KNJ    5KO1   
PDB (PDBSum)2MSV    4M67    4MWI    5KNJ    5KO1   
PDB (IMB)2MSV    4M67    4MWI    5KNJ    5KO1   
PDB (RSDB)2MSV    4M67    4MWI    5KNJ    5KO1   
Structural Biology KnowledgeBase2MSV    4M67    4MWI    5KNJ    5KO1   
SCOP (Structural Classification of Proteins)2MSV    4M67    4MWI    5KNJ    5KO1   
CATH (Classification of proteins structures)2MSV    4M67    4MWI    5KNJ    5KO1   
SuperfamilyQ8NB16
Human Protein Atlas [tissue]ENSG00000168404-MLKL [tissue]
Peptide AtlasQ8NB16
HPRD08752
IPIIPI00180781   IPI00182167   
Protein Interaction databases
DIP (DOE-UCLA)Q8NB16
IntAct (EBI)Q8NB16
FunCoupENSG00000168404
BioGRIDMLKL
STRING (EMBL)MLKL
ZODIACMLKL
Ontologies - Pathways
QuickGOQ8NB16
Ontology : AmiGOMAPK cascade  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  cell surface receptor signaling pathway  activation of JUN kinase activity  protein kinase binding  protein-containing complex binding  protein homotrimerization  necroptotic process  necroptotic process  
Ontology : EGO-EBIMAPK cascade  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  cell surface receptor signaling pathway  activation of JUN kinase activity  protein kinase binding  protein-containing complex binding  protein homotrimerization  necroptotic process  necroptotic process  
Pathways : KEGGTNF signaling pathway   
NDEx NetworkMLKL
Atlas of Cancer Signalling NetworkMLKL
Wikipedia pathwaysMLKL
Orthology - Evolution
OrthoDB197259
GeneTree (enSembl)ENSG00000168404
Phylogenetic Trees/Animal Genes : TreeFamMLKL
HOVERGENQ8NB16
HOGENOMQ8NB16
Homologs : HomoloGeneMLKL
Homology/Alignments : Family Browser (UCSC)MLKL
Gene fusions - Rearrangements
Fusion : QuiverMLKL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLKL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLKL
dbVarMLKL
ClinVarMLKL
1000_GenomesMLKL 
Exome Variant ServerMLKL
ExAC (Exome Aggregation Consortium)ENSG00000168404
GNOMAD BrowserENSG00000168404
Varsome BrowserMLKL
Genetic variants : HAPMAP197259
Genomic Variants (DGV)MLKL [DGVbeta]
DECIPHERMLKL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLKL 
Mutations
ICGC Data PortalMLKL 
TCGA Data PortalMLKL 
Broad Tumor PortalMLKL
OASIS PortalMLKL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLKL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMLKL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MLKL
DgiDB (Drug Gene Interaction Database)MLKL
DoCM (Curated mutations)MLKL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLKL (select a term)
intoGenMLKL
Cancer3DMLKL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615153   
Orphanet
DisGeNETMLKL
MedgenMLKL
Genetic Testing Registry MLKL
NextProtQ8NB16 [Medical]
TSGene197259
GENETestsMLKL
Target ValidationMLKL
Huge Navigator MLKL [HugePedia]
snp3D : Map Gene to Disease197259
BioCentury BCIQMLKL
ClinGenMLKL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD197259
Chemical/Pharm GKB GenePA142671349
Clinical trialMLKL
Miscellaneous
canSAR (ICR)MLKL (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLKL
EVEXMLKL
GoPubMedMLKL
iHOPMLKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:17:21 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.