MLKL (mixed lineage kinase domain like pseudokinase)

2006-10-01  

Identity

HGNC
MLKL
LOCATION
16q23.1
LOCUSID
197259
ALIAS
hMLKL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 197259
MIM: 615153
HGNC: 26617
Ensembl: ENSG00000168404

Variants:

dbSNP: 197259
ClinVar: 197259
TCGA: ENSG00000168404
COSMIC: MLKL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168404ENST00000306247Q8NB16
ENSG00000168404ENST00000308807Q8NB16
ENSG00000168404ENST00000571303I3L4A6
ENSG00000168404ENST00000573267I3L2T9
ENSG00000168404ENST00000575686I3L4Z5
ENSG00000168404ENST00000576529I3L2U3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Programmed Cell DeathREACTOMER-HSA-5357801
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460

References

Pubmed IDYearTitleCitations
222654132012Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.627
247039472014Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.378
243166712014Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.342
224214392012Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.237
248138852014MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.213
248138852014MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.213
236129632013Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling.77
268655332016Necroptosis and Inflammation.65
252204702014A plug release mechanism for membrane permeation by MLKL.61
286665732017MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.56

Citation

Dessen P

MLKL (mixed lineage kinase domain like pseudokinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43362/mlkl