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MLKL (mixed lineage kinase domain-like)

Identity

Alias_namesmixed lineage kinase domain-like
Alias_symbol (synonym)FLJ34389
Other aliashMLKL
HGNC (Hugo) MLKL
LocusID (NCBI) 197259
Atlas_Id 43362
Location 16q23.1  [Link to chromosome band 16q23]
Location_base_pair Starts at 74705753 and ends at 74735046 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MLKL (16q23.1) / QSOX1 (1q25.2)TLE3 (15q23) / MLKL (16q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MLKL   26617
Cards
Entrez_Gene (NCBI)MLKL  197259  mixed lineage kinase domain-like
AliaseshMLKL
GeneCards (Weizmann)MLKL
Ensembl hg19 (Hinxton)ENSG00000168404 [Gene_View]  chr16:74705753-74735046 [Contig_View]  MLKL [Vega]
Ensembl hg38 (Hinxton)ENSG00000168404 [Gene_View]  chr16:74705753-74735046 [Contig_View]  MLKL [Vega]
ICGC DataPortalENSG00000168404
TCGA cBioPortalMLKL
AceView (NCBI)MLKL
Genatlas (Paris)MLKL
WikiGenes197259
SOURCE (Princeton)MLKL
Genetics Home Reference (NIH)MLKL
Genomic and cartography
GoldenPath hg19 (UCSC)MLKL  -     chr16:74705753-74735046 -  16q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MLKL  -     16q23.1   [Description]    (hg38-Dec_2013)
EnsemblMLKL - 16q23.1 [CytoView hg19]  MLKL - 16q23.1 [CytoView hg38]
Mapping of homologs : NCBIMLKL [Mapview hg19]  MLKL [Mapview hg38]
OMIM615153   
Gene and transcription
Genbank (Entrez)AK091708 AK093013 AK122998 AL833362 BC028141
RefSeq transcript (Entrez)NM_001142497 NM_152649
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)MLKL
Cluster EST : UnigeneHs.119878 [ NCBI ]
CGAP (NCI)Hs.119878
Alternative Splicing GalleryENSG00000168404
Gene ExpressionMLKL [ NCBI-GEO ]   MLKL [ EBI - ARRAY_EXPRESS ]   MLKL [ SEEK ]   MLKL [ MEM ]
Gene Expression Viewer (FireBrowse)MLKL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)197259
GTEX Portal (Tissue expression)MLKL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NB16   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NB16  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NB16
Splice isoforms : SwissVarQ8NB16
PhosPhoSitePlusQ8NB16
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)MLKL
DMDM Disease mutations197259
Blocks (Seattle)MLKL
PDB (SRS)2MSV    4M67    4MWI   
PDB (PDBSum)2MSV    4M67    4MWI   
PDB (IMB)2MSV    4M67    4MWI   
PDB (RSDB)2MSV    4M67    4MWI   
Structural Biology KnowledgeBase2MSV    4M67    4MWI   
SCOP (Structural Classification of Proteins)2MSV    4M67    4MWI   
CATH (Classification of proteins structures)2MSV    4M67    4MWI   
SuperfamilyQ8NB16
Human Protein AtlasENSG00000168404
Peptide AtlasQ8NB16
HPRD08752
IPIIPI00180781   IPI00182167   
Protein Interaction databases
DIP (DOE-UCLA)Q8NB16
IntAct (EBI)Q8NB16
FunCoupENSG00000168404
BioGRIDMLKL
STRING (EMBL)MLKL
ZODIACMLKL
Ontologies - Pathways
QuickGOQ8NB16
Ontology : AmiGOprotein kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  protein phosphorylation  protein kinase binding  protein complex binding  protein homotrimerization  necroptotic process  necroptotic process  
Ontology : EGO-EBIprotein kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  protein phosphorylation  protein kinase binding  protein complex binding  protein homotrimerization  necroptotic process  necroptotic process  
Pathways : KEGGTNF signaling pathway   
NDEx NetworkMLKL
Atlas of Cancer Signalling NetworkMLKL
Wikipedia pathwaysMLKL
Orthology - Evolution
OrthoDB197259
GeneTree (enSembl)ENSG00000168404
Phylogenetic Trees/Animal Genes : TreeFamMLKL
HOVERGENQ8NB16
HOGENOMQ8NB16
Homologs : HomoloGeneMLKL
Homology/Alignments : Family Browser (UCSC)MLKL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLKL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLKL
dbVarMLKL
ClinVarMLKL
1000_GenomesMLKL 
Exome Variant ServerMLKL
ExAC (Exome Aggregation Consortium)MLKL (select the gene name)
Genetic variants : HAPMAP197259
Genomic Variants (DGV)MLKL [DGVbeta]
DECIPHER (Syndromes)16:74705753-74735046  ENSG00000168404
CONAN: Copy Number AnalysisMLKL 
Mutations
ICGC Data PortalMLKL 
TCGA Data PortalMLKL 
Broad Tumor PortalMLKL
OASIS PortalMLKL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLKL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMLKL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MLKL
DgiDB (Drug Gene Interaction Database)MLKL
DoCM (Curated mutations)MLKL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLKL (select a term)
intoGenMLKL
Cancer3DMLKL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615153   
Orphanet
MedgenMLKL
Genetic Testing Registry MLKL
NextProtQ8NB16 [Medical]
TSGene197259
GENETestsMLKL
Huge Navigator MLKL [HugePedia]
snp3D : Map Gene to Disease197259
BioCentury BCIQMLKL
ClinGenMLKL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD197259
Chemical/Pharm GKB GenePA142671349
Clinical trialMLKL
Miscellaneous
canSAR (ICR)MLKL (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLKL
EVEXMLKL
GoPubMedMLKL
iHOPMLKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:10:46 CEST 2017

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