MLN (motilin)

2014-11-01  

Identity

HGNC
LOCATION
6p21.31
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 4295
MIM: 158270
HGNC: 7141
Ensembl: ENSG00000096395

Variants:

dbSNP: 4295
ClinVar: 4295
TCGA: ENSG00000096395
COSMIC: MLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000096395ENST00000266003P12872
ENSG00000096395ENST00000430124P12872
ENSG00000096395ENST00000507738P12872

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
175952552007Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine.17
203382102010Covariation of plasma ghrelin and motilin in irritable bowel syndrome.11
226328572012Ghrelin and motilin in the gastrointestinal system.10
182346402008Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones.4
266605372016Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.4
217719712011Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage.3
183582792008Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis.2
186096942008Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin.2
285663042017Circulating motilin, ghrelin, and GLP-1 and their correlations with gastric slow waves in patients with chronic kidney disease.1

Citation

Dessen P

MLN (motilin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70343/mln