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MLX (MLX, MAX dimerization protein)

Identity

Alias_namesTCFL4
transcription factor-like 4
MAX-like protein X
Alias_symbol (synonym)MAD7
MXD7
bHLHd13
Other aliasTF4
HGNC (Hugo) MLX
LocusID (NCBI) 6945
Atlas_Id 78577
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42567060 and ends at 42573203 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCL2L2-PABPN1 (14q11.2) / MLX (17q21.2)MLX (17q21.2) / MLX (17q21.2)PEX2 (8q21.11) / MLX (17q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MLX   11645
Cards
Entrez_Gene (NCBI)MLX  6945  MLX, MAX dimerization protein
AliasesMAD7; MXD7; TCFL4; TF4; 
bHLHd13
GeneCards (Weizmann)MLX
Ensembl hg19 (Hinxton)ENSG00000108788 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108788 [Gene_View]  chr17:42567060-42573203 [Contig_View]  MLX [Vega]
ICGC DataPortalENSG00000108788
TCGA cBioPortalMLX
AceView (NCBI)MLX
Genatlas (Paris)MLX
WikiGenes6945
SOURCE (Princeton)MLX
Genetics Home Reference (NIH)MLX
Genomic and cartography
GoldenPath hg38 (UCSC)MLX  -     chr17:42567060-42573203 +  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLX  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblMLX - 17q21.2 [CytoView hg19]  MLX - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIMLX [Mapview hg19]  MLX [Mapview hg38]
OMIM602976   
Gene and transcription
Genbank (Entrez)AA024982 AB209235 AF203978 AF213666 AF213667
RefSeq transcript (Entrez)NM_170607 NM_198204 NM_198205
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MLX
Cluster EST : UnigeneHs.714749 [ NCBI ]
CGAP (NCI)Hs.714749
Alternative Splicing GalleryENSG00000108788
Gene ExpressionMLX [ NCBI-GEO ]   MLX [ EBI - ARRAY_EXPRESS ]   MLX [ SEEK ]   MLX [ MEM ]
Gene Expression Viewer (FireBrowse)MLX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6945
GTEX Portal (Tissue expression)MLX
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UH92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UH92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UH92
Splice isoforms : SwissVarQ9UH92
PhosPhoSitePlusQ9UH92
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    Mlx   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)MLX
DMDM Disease mutations6945
Blocks (Seattle)MLX
SuperfamilyQ9UH92
Human Protein AtlasENSG00000108788
Peptide AtlasQ9UH92
HPRD04278
IPIIPI00005661   IPI00219786   IPI00101383   IPI00910022   IPI00556177   
Protein Interaction databases
DIP (DOE-UCLA)Q9UH92
IntAct (EBI)Q9UH92
FunCoupENSG00000108788
BioGRIDMLX
STRING (EMBL)MLX
ZODIACMLX
Ontologies - Pathways
QuickGOQ9UH92
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  transcription factor binding  nuclear membrane  protein homodimerization activity  negative regulation of transcription, DNA-templated  protein heterodimerization activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  transcription factor binding  nuclear membrane  protein homodimerization activity  negative regulation of transcription, DNA-templated  protein heterodimerization activity  
Pathways : KEGGNon-alcoholic fatty liver disease (NAFLD)   
NDEx NetworkMLX
Atlas of Cancer Signalling NetworkMLX
Wikipedia pathwaysMLX
Orthology - Evolution
OrthoDB6945
GeneTree (enSembl)ENSG00000108788
Phylogenetic Trees/Animal Genes : TreeFamMLX
HOVERGENQ9UH92
HOGENOMQ9UH92
Homologs : HomoloGeneMLX
Homology/Alignments : Family Browser (UCSC)MLX
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLX
dbVarMLX
ClinVarMLX
1000_GenomesMLX 
Exome Variant ServerMLX
ExAC (Exome Aggregation Consortium)MLX (select the gene name)
Genetic variants : HAPMAP6945
Genomic Variants (DGV)MLX [DGVbeta]
DECIPHERMLX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLX 
Mutations
ICGC Data PortalMLX 
TCGA Data PortalMLX 
Broad Tumor PortalMLX
OASIS PortalMLX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMLX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MLX
DgiDB (Drug Gene Interaction Database)MLX
DoCM (Curated mutations)MLX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLX (select a term)
intoGenMLX
Cancer3DMLX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602976   
Orphanet806   
MedgenMLX
Genetic Testing Registry MLX
NextProtQ9UH92 [Medical]
TSGene6945
GENETestsMLX
Target ValidationMLX
Huge Navigator MLX [HugePedia]
snp3D : Map Gene to Disease6945
BioCentury BCIQMLX
ClinGenMLX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6945
Chemical/Pharm GKB GenePA36397
Clinical trialMLX
Miscellaneous
canSAR (ICR)MLX (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLX
EVEXMLX
GoPubMedMLX
iHOPMLX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:31:08 CEST 2017

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