MLXIP (MLX interacting protein)

2012-10-01  

Identity

HGNC
MLXIP
LOCATION
12q24.31
LOCUSID
22877
ALIAS
MIR,MONDOA,bHLHe36
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22877
MIM: 608090
HGNC: 17055
Ensembl: ENSG00000175727

Variants:

dbSNP: 22877
ClinVar: 22877
TCGA: ENSG00000175727
COSMIC: MLXIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175727ENST00000319080Q9HAP2
ENSG00000175727ENST00000366272F5H0V4
ENSG00000175727ENST00000366272A0A0G2JR68
ENSG00000175727ENST00000377037Q9HAP2
ENSG00000175727ENST00000535430A0A0G2JRQ8
ENSG00000175727ENST00000535430F5H321
ENSG00000175727ENST00000538698Q9HAP2
ENSG00000175727ENST00000542417H0YGR9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184583402008Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.101
197064882009Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.65
256404022015Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.62
208447682010Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.53
167828752006MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.51
203857672010Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer.40
219086212011MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.25
124467712002A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.23
253322332015MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.13
275004912016MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.10

Citation

Dessen P

MLXIP (MLX interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52918/mlxip