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MLYCD (malonyl-CoA decarboxylase)

Identity

Alias (NCBI)MCD
HGNC (Hugo) MLYCD
HGNC Alias symbMCD
hMCD
LocusID (NCBI) 23417
Atlas_Id 54463
Location 16q23.3  [Link to chromosome band 16q23]
Location_base_pair Starts at 83899115 and ends at 83927031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH13 (16q23.3) / MLYCD (16q23.3)MLYCD (16q23.3) / MGRN1 (16p13.3)MLYCD (16q23.3) / MLYCD (16q23.3)
MLYCD (16q23.3) / OSGIN1 (16q23.3)MLYCD 16q23.3 / MGRN1 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;21)(q23;q22) RUNX1/MLYCD


External links

 

Nomenclature
HGNC (Hugo)MLYCD   7150
Cards
Entrez_Gene (NCBI)MLYCD    malonyl-CoA decarboxylase
AliasesMCD
GeneCards (Weizmann)MLYCD
Ensembl hg19 (Hinxton)ENSG00000103150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103150 [Gene_View]  ENSG00000103150 [Sequence]  chr16:83899115-83927031 [Contig_View]  MLYCD [Vega]
ICGC DataPortalENSG00000103150
TCGA cBioPortalMLYCD
AceView (NCBI)MLYCD
Genatlas (Paris)MLYCD
SOURCE (Princeton)MLYCD
Genetics Home Reference (NIH)MLYCD
Genomic and cartography
GoldenPath hg38 (UCSC)MLYCD  -     chr16:83899115-83927031 +  16q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLYCD  -     16q23.3   [Description]    (hg19-Feb_2009)
GoldenPathMLYCD - 16q23.3 [CytoView hg19]  MLYCD - 16q23.3 [CytoView hg38]
ImmunoBaseENSG00000103150
Genome Data Viewer NCBIMLYCD [Mapview hg19]  
OMIM248360   606761   
Gene and transcription
Genbank (Entrez)AF090834 AF097832 AF153679 AK094095 BC000286
RefSeq transcript (Entrez)NM_012213
Consensus coding sequences : CCDS (NCBI)MLYCD
Gene ExpressionMLYCD [ NCBI-GEO ]   MLYCD [ EBI - ARRAY_EXPRESS ]   MLYCD [ SEEK ]   MLYCD [ MEM ]
Gene Expression Viewer (FireBrowse)MLYCD [ Firebrowse - Broad ]
GenevisibleExpression of MLYCD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23417
GTEX Portal (Tissue expression)MLYCD
Human Protein AtlasENSG00000103150-MLYCD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95822   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95822  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95822
PhosPhoSitePlusO95822
Domains : Interpro (EBI)Malonyl_CoA_deC    Malonyl_CoA_deC_C    Malonyl_CoA_deC_C_sf    MCD_N    MCD_N_sf   
Domain families : Pfam (Sanger)MCD (PF05292)    MCD_N (PF17408)   
Domain families : Pfam (NCBI)pfam05292    pfam17408   
Conserved Domain (NCBI)MLYCD
PDB (RSDB)2YGW    4F0X   
PDB Europe2YGW    4F0X   
PDB (PDBSum)2YGW    4F0X   
PDB (IMB)2YGW    4F0X   
Structural Biology KnowledgeBase2YGW    4F0X   
SCOP (Structural Classification of Proteins)2YGW    4F0X   
CATH (Classification of proteins structures)2YGW    4F0X   
SuperfamilyO95822
AlphaFold pdb e-kbO95822   
Human Protein Atlas [tissue]ENSG00000103150-MLYCD [tissue]
HPRD05999
Protein Interaction databases
DIP (DOE-UCLA)O95822
IntAct (EBI)O95822
BioGRIDMLYCD
STRING (EMBL)MLYCD
ZODIACMLYCD
Ontologies - Pathways
QuickGOO95822
Ontology : AmiGOresponse to ischemia  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  peroxisome  peroxisomal matrix  peroxisomal matrix  peroxisomal matrix  cytosol  acetyl-CoA biosynthetic process  acetyl-CoA biosynthetic process  acetyl-CoA biosynthetic process  fatty acid biosynthetic process  acyl-CoA metabolic process  protein localization  regulation of glucose metabolic process  fatty acid oxidation  regulation of fatty acid beta-oxidation  identical protein binding  positive regulation of fatty acid oxidation  positive regulation of fatty acid oxidation  malonyl-CoA decarboxylase activity  malonyl-CoA decarboxylase activity  malonyl-CoA catabolic process  malonyl-CoA catabolic process  
Ontology : EGO-EBIresponse to ischemia  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  peroxisome  peroxisomal matrix  peroxisomal matrix  peroxisomal matrix  cytosol  acetyl-CoA biosynthetic process  acetyl-CoA biosynthetic process  acetyl-CoA biosynthetic process  fatty acid biosynthetic process  acyl-CoA metabolic process  protein localization  regulation of glucose metabolic process  fatty acid oxidation  regulation of fatty acid beta-oxidation  identical protein binding  positive regulation of fatty acid oxidation  positive regulation of fatty acid oxidation  malonyl-CoA decarboxylase activity  malonyl-CoA decarboxylase activity  malonyl-CoA catabolic process  malonyl-CoA catabolic process  
Pathways : KEGGbeta-Alanine metabolism    Propanoate metabolism    Peroxisome   
NDEx NetworkMLYCD
Atlas of Cancer Signalling NetworkMLYCD
Wikipedia pathwaysMLYCD
Orthology - Evolution
OrthoDB23417
GeneTree (enSembl)ENSG00000103150
Phylogenetic Trees/Animal Genes : TreeFamMLYCD
Homologs : HomoloGeneMLYCD
Homology/Alignments : Family Browser (UCSC)MLYCD
Gene fusions - Rearrangements
Fusion : MitelmanCDH13/MLYCD [16q23.3/16q23.3]  
Fusion : MitelmanMLYCD/MGRN1 [16q23.3/16p13.3]  
Fusion : QuiverMLYCD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLYCD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLYCD
dbVarMLYCD
ClinVarMLYCD
MonarchMLYCD
1000_GenomesMLYCD 
Exome Variant ServerMLYCD
GNOMAD BrowserENSG00000103150
Varsome BrowserMLYCD
ACMGMLYCD variants
VarityO95822
Genomic Variants (DGV)MLYCD [DGVbeta]
DECIPHERMLYCD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLYCD 
Mutations
ICGC Data PortalMLYCD 
TCGA Data PortalMLYCD 
Broad Tumor PortalMLYCD
OASIS PortalMLYCD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMLYCD  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMLYCD
Mutations and Diseases : HGMDMLYCD
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMLYCD
DgiDB (Drug Gene Interaction Database)MLYCD
DoCM (Curated mutations)MLYCD
CIViC (Clinical Interpretations of Variants in Cancer)MLYCD
Cancer3DMLYCD
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM248360    606761   
Orphanet3295   
DisGeNETMLYCD
MedgenMLYCD
Genetic Testing Registry MLYCD
NextProtO95822 [Medical]
GENETestsMLYCD
Target ValidationMLYCD
Huge Navigator MLYCD [HugePedia]
ClinGenMLYCD
Clinical trials, drugs, therapy
MyCancerGenomeMLYCD
Protein Interactions : CTDMLYCD
Pharm GKB GenePA30861
Pharm GKB PathwaysPA165948566   
PharosO95822
Clinical trialMLYCD
Miscellaneous
canSAR (ICR)MLYCD
HarmonizomeMLYCD
DataMed IndexMLYCD
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMLYCD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:21:01 CEST 2021

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