Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MMP1 (matrix metallopeptidase 1)

Identity

Alias_namesCLG
matrix metalloproteinase 1 (interstitial collagenase)
Other aliasCLGN
HGNC (Hugo) MMP1
LocusID (NCBI) 4312
Atlas_Id 41387
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102789910 and ends at 102798235 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MMP1   7155
Cards
Entrez_Gene (NCBI)MMP1  4312  matrix metallopeptidase 1
AliasesCLG; CLGN
GeneCards (Weizmann)MMP1
Ensembl hg19 (Hinxton)ENSG00000196611 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196611 [Gene_View]  ENSG00000196611 [Sequence]  chr11:102789910-102798235 [Contig_View]  MMP1 [Vega]
ICGC DataPortalENSG00000196611
TCGA cBioPortalMMP1
AceView (NCBI)MMP1
Genatlas (Paris)MMP1
WikiGenes4312
SOURCE (Princeton)MMP1
Genetics Home Reference (NIH)MMP1
Genomic and cartography
GoldenPath hg38 (UCSC)MMP1  -     chr11:102789910-102798235 -  11q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP1  -     11q22.2   [Description]    (hg19-Feb_2009)
EnsemblMMP1 - 11q22.2 [CytoView hg19]  MMP1 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP1 [Mapview hg19]  MMP1 [Mapview hg38]
OMIM120353   226600   606963   
Gene and transcription
Genbank (Entrez)AK024818 AK098450 AK130687 AK223034 AK223035
RefSeq transcript (Entrez)NM_001145938 NM_002421
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP1
Cluster EST : UnigeneHs.83169 [ NCBI ]
CGAP (NCI)Hs.83169
Alternative Splicing GalleryENSG00000196611
Gene ExpressionMMP1 [ NCBI-GEO ]   MMP1 [ EBI - ARRAY_EXPRESS ]   MMP1 [ SEEK ]   MMP1 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4312
GTEX Portal (Tissue expression)MMP1
Human Protein AtlasENSG00000196611-MMP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP03956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP03956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP03956
Splice isoforms : SwissVarP03956
PhosPhoSitePlusP03956
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_dom_sf    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom_sf    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like    PGBD-like_sf   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP1
DMDM Disease mutations4312
Blocks (Seattle)MMP1
PDB (SRS)1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
PDB (PDBSum)1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
PDB (IMB)1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
PDB (RSDB)1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
Structural Biology KnowledgeBase1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
SCOP (Structural Classification of Proteins)1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
CATH (Classification of proteins structures)1AYK    1CGE    1CGF    1CGL    1HFC    1SU3    2AYK    2CLT    2J0T    2TCL    3AYK    3SHI    4AUO    4AYK    966C   
SuperfamilyP03956
Human Protein Atlas [tissue]ENSG00000196611-MMP1 [tissue]
Peptide AtlasP03956
HPRD00384
IPIIPI00008561   IPI00924810   
Protein Interaction databases
DIP (DOE-UCLA)P03956
IntAct (EBI)P03956
FunCoupENSG00000196611
BioGRIDMMP1
STRING (EMBL)MMP1
ZODIACMMP1
Ontologies - Pathways
QuickGOP03956
Ontology : AmiGOendopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  extracellular region  extracellular space  proteolysis  zinc ion binding  viral process  cytokine-mediated signaling pathway  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  positive regulation of protein oligomerization  cellular protein metabolic process  leukocyte migration  
Ontology : EGO-EBIendopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  extracellular region  extracellular space  proteolysis  zinc ion binding  viral process  cytokine-mediated signaling pathway  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  positive regulation of protein oligomerization  cellular protein metabolic process  leukocyte migration  
Pathways : KEGGPPAR signaling pathway    Pathways in cancer    Bladder cancer    Rheumatoid arthritis   
NDEx NetworkMMP1
Atlas of Cancer Signalling NetworkMMP1
Wikipedia pathwaysMMP1
Orthology - Evolution
OrthoDB4312
GeneTree (enSembl)ENSG00000196611
Phylogenetic Trees/Animal Genes : TreeFamMMP1
HOGENOMP03956
Homologs : HomoloGeneMMP1
Homology/Alignments : Family Browser (UCSC)MMP1
Gene fusions - Rearrangements
Fusion : QuiverMMP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP1
dbVarMMP1
ClinVarMMP1
1000_GenomesMMP1 
Exome Variant ServerMMP1
ExAC (Exome Aggregation Consortium)ENSG00000196611
GNOMAD BrowserENSG00000196611
Varsome BrowserMMP1
Genetic variants : HAPMAP4312
Genomic Variants (DGV)MMP1 [DGVbeta]
DECIPHERMMP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP1 
Mutations
ICGC Data PortalMMP1 
TCGA Data PortalMMP1 
Broad Tumor PortalMMP1
OASIS PortalMMP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP1
DgiDB (Drug Gene Interaction Database)MMP1
DoCM (Curated mutations)MMP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP1 (select a term)
intoGenMMP1
Cancer3DMMP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120353    226600    606963   
Orphanet11434   
DisGeNETMMP1
MedgenMMP1
Genetic Testing Registry MMP1
NextProtP03956 [Medical]
TSGene4312
GENETestsMMP1
Target ValidationMMP1
Huge Navigator MMP1 [HugePedia]
snp3D : Map Gene to Disease4312
BioCentury BCIQMMP1
ClinGenMMP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4312
Chemical/Pharm GKB GenePA30867
Clinical trialMMP1
Miscellaneous
canSAR (ICR)MMP1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP1
EVEXMMP1
GoPubMedMMP1
iHOPMMP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Dec 21 15:36:25 CET 2018
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