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MMP10 (matrix metallopeptidase 10)

Identity

Other namesSL-2
STMY2
HGNC (Hugo) MMP10
LocusID (NCBI) 4319
Atlas_Id 41388
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102641233 and ends at 102651359 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NARS2 (11q14.1) / MMP10 (11q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;9)(p13;p12) PAX5/HIPK1

External links

Nomenclature
HGNC (Hugo)MMP10   7156
Cards
Entrez_Gene (NCBI)MMP10  4319  matrix metallopeptidase 10
AliasesSL-2; STMY2
GeneCards (Weizmann)MMP10
Ensembl hg19 (Hinxton)ENSG00000166670 [Gene_View]  chr11:102641233-102651359 [Contig_View]  MMP10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166670 [Gene_View]  chr11:102641233-102651359 [Contig_View]  MMP10 [Vega]
ICGC DataPortalENSG00000166670
TCGA cBioPortalMMP10
AceView (NCBI)MMP10
Genatlas (Paris)MMP10
WikiGenes4319
SOURCE (Princeton)MMP10
Genomic and cartography
GoldenPath hg19 (UCSC)MMP10  -     chr11:102641233-102651359 -  11q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MMP10  -     11q22.2   [Description]    (hg38-Dec_2013)
EnsemblMMP10 - 11q22.2 [CytoView hg19]  MMP10 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP10 [Mapview hg19]  MMP10 [Mapview hg38]
OMIM185260   
Gene and transcription
Genbank (Entrez)AK222601 AK313960 BC002591 BT007442 DQ891931
RefSeq transcript (Entrez)NM_002425
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)MMP10
Cluster EST : UnigeneHs.2258 [ NCBI ]
CGAP (NCI)Hs.2258
Alternative Splicing GalleryENSG00000166670
Gene ExpressionMMP10 [ NCBI-GEO ]   MMP10 [ EBI - ARRAY_EXPRESS ]   MMP10 [ SEEK ]   MMP10 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4319
GTEX Portal (Tissue expression)MMP10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09238 (Uniprot)
NextProtP09238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09238
Splice isoforms : SwissVarP09238 (Swissvar)
Catalytic activity : Enzyme3.4.24.22 [ Enzyme-Expasy ]   3.4.24.223.4.24.22 [ IntEnz-EBI ]   3.4.24.22 [ BRENDA ]   3.4.24.22 [ KEGG ]   
PhosPhoSitePlusP09238
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    Hemopexin_CS    MetalloPept_cat_dom    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_stromelysin-type    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
DMDM Disease mutations4319
Blocks (Seattle)MMP10
PDB (SRS)1Q3A    3V96    4ILW   
PDB (PDBSum)1Q3A    3V96    4ILW   
PDB (IMB)1Q3A    3V96    4ILW   
PDB (RSDB)1Q3A    3V96    4ILW   
Structural Biology KnowledgeBase1Q3A    3V96    4ILW   
SCOP (Structural Classification of Proteins)1Q3A    3V96    4ILW   
CATH (Classification of proteins structures)1Q3A    3V96    4ILW   
SuperfamilyP09238
Human Protein AtlasENSG00000166670
Peptide AtlasP09238
HPRD01704
IPIIPI00013405   IPI01012130   
Protein Interaction databases
DIP (DOE-UCLA)P09238
IntAct (EBI)P09238
FunCoupENSG00000166670
BioGRIDMMP10
STRING (EMBL)MMP10
ZODIACMMP10
Ontologies - Pathways
QuickGOP09238
Ontology : AmiGOmetalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  extracellular matrix disassembly  regulation of cell migration  collagen catabolic process  
Ontology : EGO-EBImetalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  extracellular matrix disassembly  regulation of cell migration  collagen catabolic process  
NDEx Network
Atlas of Cancer Signalling NetworkMMP10
Wikipedia pathwaysMMP10
Orthology - Evolution
OrthoDB4319
GeneTree (enSembl)ENSG00000166670
Phylogenetic Trees/Animal Genes : TreeFamMMP10
Homologs : HomoloGeneMMP10
Homology/Alignments : Family Browser (UCSC)MMP10
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMMP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP10
dbVarMMP10
ClinVarMMP10
1000_GenomesMMP10 
Exome Variant ServerMMP10
ExAC (Exome Aggregation Consortium)MMP10 (select the gene name)
Genetic variants : HAPMAP4319
Genomic Variants (DGV)MMP10 [DGVbeta]
Mutations
ICGC Data PortalMMP10 
TCGA Data PortalMMP10 
Broad Tumor PortalMMP10
OASIS PortalMMP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP10 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP10
DgiDB (Drug Gene Interaction Database)MMP10
DoCM (Curated mutations)MMP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP10 (select a term)
intoGenMMP10
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:102641233-102651359  ENSG00000166670
CONAN: Copy Number AnalysisMMP10 
Mutations and Diseases : HGMDMMP10
OMIM185260   
MedgenMMP10
Genetic Testing Registry MMP10
NextProtP09238 [Medical]
TSGene4319
GENETestsMMP10
Huge Navigator MMP10 [HugePedia]
snp3D : Map Gene to Disease4319
BioCentury BCIQMMP10
ClinGenMMP10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4319
Chemical/Pharm GKB GenePA30868
Clinical trialMMP10
Miscellaneous
canSAR (ICR)MMP10 (select the gene name)
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP10
EVEXMMP10
GoPubMedMMP10
iHOPMMP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:45 CEST 2016

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