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MMP11 (matrix metalloproteinase 11 (stromelysin 3))

Written2000-03Paul Basset, Marie-Christine Rio
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM U184/ULP BP 163, Illkirch, CU de Strasbourg, France

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Identity

Alias (NCBI)ST3 (stromelysin-3)
MMP-11 (matrix metalloproteinase 11)
LocusID (NCBI) 4320
Atlas_Id 200
Location 22q11.23  [Link to chromosome band 22q11]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MMP11 (22q11.23)::YKT6 (7p13)MMP11 (22q11.23)::ZNF714 (19p12)

DNA/RNA

Description 8 exons and 7 introns spanning 11.5 kb; cDNA: 2247 bp, coding sequence 1464 bp
Transcription expression is induced by retinoic acid and TPA through a DR1-type responsive element and a C/EBP binding site, respectively, expression is induced by epithelial cells in a paracrin manner

Protein

Description 488 amino-acids; 51 kDa; functional domains: signal peptide, targeting the protein to the secretory pathway, prodomain containing a furin-type cleavage site responsible for the intracellular activation, catalytic domain containing a zinc binding site, hemopexin-like domain
Expression cells of mesenchymal origin, notably fibroblastic cells, macrophages, osteoclasts
Function extracellular zinc-dependent proteinase expressed during tissu remodelling processes (development, wound healing) and whose specific substrate is unknown
Homology member of the matrix metalloproteinases (MMP) subfamily of matrixins

Implicated in

Note
  
Entity various cancer:
  

Citation

This paper should be referenced as such :
Basset, P ; Rio, MC
MMP11 (matrix metalloproteinase 11 (stromelysin 3))
Atlas Genet Cytogenet Oncol Haematol. 2000;4(2):52-53.
Free journal version : [ pdf ]   [ DOI ]

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