Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MMP12 (matrix metallopeptidase 12)

Identity

Alias_namesmatrix metalloproteinase 12 (macrophage elastase)
Alias_symbol (synonym)HME
Other aliasME
MME
MMP-12
HGNC (Hugo) MMP12
LocusID (NCBI) 4321
Atlas_Id 41389
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102733460 and ends at 102745764 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MMP12 (11q22.2) / TMEM232 (5q22.1)TNS2 (12q13.13) / MMP12 (11q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP12   7158
Cards
Entrez_Gene (NCBI)MMP12  4321  matrix metallopeptidase 12
AliasesHME; ME; MME; MMP-12
GeneCards (Weizmann)MMP12
Ensembl hg19 (Hinxton)ENSG00000262406 [Gene_View]  chr11:102733460-102745764 [Contig_View]  MMP12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000262406 [Gene_View]  chr11:102733460-102745764 [Contig_View]  MMP12 [Vega]
ICGC DataPortalENSG00000262406
TCGA cBioPortalMMP12
AceView (NCBI)MMP12
Genatlas (Paris)MMP12
WikiGenes4321
SOURCE (Princeton)MMP12
Genetics Home Reference (NIH)MMP12
Genomic and cartography
GoldenPath hg19 (UCSC)MMP12  -     chr11:102733460-102745764 -  11q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MMP12  -     11q22.2   [Description]    (hg38-Dec_2013)
EnsemblMMP12 - 11q22.2 [CytoView hg19]  MMP12 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP12 [Mapview hg19]  MMP12 [Mapview hg38]
OMIM601046   
Gene and transcription
Genbank (Entrez)AI343504 AI352562 AK313959 AW172994 BC112301
RefSeq transcript (Entrez)NM_002426
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_032936 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)MMP12
Cluster EST : UnigeneHs.709832 [ NCBI ]
CGAP (NCI)Hs.709832
Alternative Splicing GalleryENSG00000262406
Gene ExpressionMMP12 [ NCBI-GEO ]   MMP12 [ EBI - ARRAY_EXPRESS ]   MMP12 [ SEEK ]   MMP12 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4321
GTEX Portal (Tissue expression)MMP12
Protein : pattern, domain, 3D structure
UniProt/SwissProtP39900   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP39900  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP39900
Splice isoforms : SwissVarP39900
Catalytic activity : Enzyme3.4.24.65 [ Enzyme-Expasy ]   3.4.24.653.4.24.65 [ IntEnz-EBI ]   3.4.24.65 [ BRENDA ]   3.4.24.65 [ KEGG ]   
PhosPhoSitePlusP39900
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    Hemopexin_CS    MetalloPept_cat_dom    MMP12    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_stromelysin-type    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP12
DMDM Disease mutations4321
Blocks (Seattle)MMP12
PDB (SRS)1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
PDB (PDBSum)1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
PDB (IMB)1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
PDB (RSDB)1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
Structural Biology KnowledgeBase1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
SCOP (Structural Classification of Proteins)1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
CATH (Classification of proteins structures)1JIZ    1JK3    1OS2    1OS9    1RMZ    1ROS    1UTT    1UTZ    1Y93    1YCM    1Z3J    2HU6    2JXY    2K2G    2K9C    2KRJ    2MLR    2MLS    2OXU    2OXW    2OXZ    2POJ    2W0D    2WO8    2WO9    2WOA    2Z2D    3BA0    3EHX    3EHY    3F15    3F16    3F17    3F18    3F19    3F1A    3LIK    3LIL    3LIR    3LJG    3LK8    3LKA    3N2U    3N2V    3NX7    3RTS    3RTT    3TS4    3TSK    3UVC    4EFS    4GQL    4GR0    4GR3    4GR8    4GUY    4H30    4H49    4H76    4H84    4I03    4IJO   
SuperfamilyP39900
Human Protein AtlasENSG00000262406
Peptide AtlasP39900
HPRD03027
IPIIPI00298246   
Protein Interaction databases
DIP (DOE-UCLA)P39900
IntAct (EBI)P39900
FunCoupENSG00000262406
BioGRIDMMP12
STRING (EMBL)MMP12
ZODIACMMP12
Ontologies - Pathways
QuickGOP39900
Ontology : AmiGOendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  proteolysis  zinc ion binding  response to organic cyclic compound  extracellular matrix disassembly  collagen catabolic process  wound healing, spreading of epidermal cells  response to drug  positive regulation of epithelial cell proliferation involved in wound healing  
Ontology : EGO-EBIendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  proteolysis  zinc ion binding  response to organic cyclic compound  extracellular matrix disassembly  collagen catabolic process  wound healing, spreading of epidermal cells  response to drug  positive regulation of epithelial cell proliferation involved in wound healing  
NDEx NetworkMMP12
Atlas of Cancer Signalling NetworkMMP12
Wikipedia pathwaysMMP12
Orthology - Evolution
OrthoDB4321
GeneTree (enSembl)ENSG00000262406
Phylogenetic Trees/Animal Genes : TreeFamMMP12
HOVERGENP39900
HOGENOMP39900
Homologs : HomoloGeneMMP12
Homology/Alignments : Family Browser (UCSC)MMP12
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP12
dbVarMMP12
ClinVarMMP12
1000_GenomesMMP12 
Exome Variant ServerMMP12
ExAC (Exome Aggregation Consortium)MMP12 (select the gene name)
Genetic variants : HAPMAP4321
Genomic Variants (DGV)MMP12 [DGVbeta]
DECIPHER (Syndromes)11:102733460-102745764  ENSG00000262406
CONAN: Copy Number AnalysisMMP12 
Mutations
ICGC Data PortalMMP12 
TCGA Data PortalMMP12 
Broad Tumor PortalMMP12
OASIS PortalMMP12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP12
DgiDB (Drug Gene Interaction Database)MMP12
DoCM (Curated mutations)MMP12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP12 (select a term)
intoGenMMP12
Cancer3DMMP12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601046   
Orphanet
MedgenMMP12
Genetic Testing Registry MMP12
NextProtP39900 [Medical]
TSGene4321
GENETestsMMP12
Huge Navigator MMP12 [HugePedia]
snp3D : Map Gene to Disease4321
BioCentury BCIQMMP12
ClinGenMMP12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4321
Chemical/Pharm GKB GenePA30870
Clinical trialMMP12
Miscellaneous
canSAR (ICR)MMP12 (select the gene name)
Probes
Litterature
PubMed154 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP12
EVEXMMP12
GoPubMedMMP12
iHOPMMP12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:17:07 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.