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MMP16 (matrix metallopeptidase 16)

Identity

Alias_namesC8orf57
matrix metalloproteinase 16 (membrane-inserted)
chromosome 8 open reading frame 57
matrix metallopeptidase 16 (membrane-inserted)
Alias_symbol (synonym)MT3-MMP
DKFZp761D112
Other aliasMMP-X2
MT-MMP2
MT-MMP3
HGNC (Hugo) MMP16
LocusID (NCBI) 4325
Atlas_Id 41393
Location 8q21.3  [Link to chromosome band 8q21]
Location_base_pair Starts at 88037232 and ends at 88327488 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MMP16 (8q21.3) / ANKRD13A (12q24.11)MMP16 (8q21.3) / EIF3E (8q23.1)PAX3 (2q36.1) / MMP16 (8q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP16   7162
Cards
Entrez_Gene (NCBI)MMP16  4325  matrix metallopeptidase 16
AliasesC8orf57; MMP-X2; MT-MMP2; MT-MMP3; 
MT3-MMP
GeneCards (Weizmann)MMP16
Ensembl hg19 (Hinxton)ENSG00000156103 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156103 [Gene_View]  chr8:88037232-88327488 [Contig_View]  MMP16 [Vega]
ICGC DataPortalENSG00000156103
TCGA cBioPortalMMP16
AceView (NCBI)MMP16
Genatlas (Paris)MMP16
WikiGenes4325
SOURCE (Princeton)MMP16
Genetics Home Reference (NIH)MMP16
Genomic and cartography
GoldenPath hg38 (UCSC)MMP16  -     chr8:88037232-88327488 -  8q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP16  -     8q21.3   [Description]    (hg19-Feb_2009)
EnsemblMMP16 - 8q21.3 [CytoView hg19]  MMP16 - 8q21.3 [CytoView hg38]
Mapping of homologs : NCBIMMP16 [Mapview hg19]  MMP16 [Mapview hg38]
OMIM602262   
Gene and transcription
Genbank (Entrez)AB009303 AK314274 AL136588 AL832595 BC069500
RefSeq transcript (Entrez)NM_005941 NM_022564 NM_032297
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP16
Cluster EST : UnigeneHs.546267 [ NCBI ]
CGAP (NCI)Hs.546267
Alternative Splicing GalleryENSG00000156103
Gene ExpressionMMP16 [ NCBI-GEO ]   MMP16 [ EBI - ARRAY_EXPRESS ]   MMP16 [ SEEK ]   MMP16 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4325
GTEX Portal (Tissue expression)MMP16
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51512   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51512  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51512
Splice isoforms : SwissVarP51512
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusP51512
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom    MMP16    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_metallopeptidase_C    Pept_M10A_stromelysin-type    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)DUF3377 (PF11857)    Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam11857    pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP16
DMDM Disease mutations4325
Blocks (Seattle)MMP16
PDB (SRS)1RM8   
PDB (PDBSum)1RM8   
PDB (IMB)1RM8   
PDB (RSDB)1RM8   
Structural Biology KnowledgeBase1RM8   
SCOP (Structural Classification of Proteins)1RM8   
CATH (Classification of proteins structures)1RM8   
SuperfamilyP51512
Human Protein AtlasENSG00000156103
Peptide AtlasP51512
HPRD03776
IPIIPI00019243   IPI00221078   IPI00031099   IPI00974106   
Protein Interaction databases
DIP (DOE-UCLA)P51512
IntAct (EBI)P51512
FunCoupENSG00000156103
BioGRIDMMP16
STRING (EMBL)MMP16
ZODIACMMP16
Ontologies - Pathways
QuickGOP51512
Ontology : AmiGOendochondral ossification  metalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  Golgi lumen  plasma membrane  integral component of plasma membrane  proteolysis  proteolysis  enzyme activator activity  zinc ion binding  cell surface  protein processing  protein metabolic process  extracellular matrix disassembly  collagen catabolic process  chondrocyte proliferation  positive regulation of catalytic activity  embryonic cranial skeleton morphogenesis  metalloaminopeptidase activity  metalloaminopeptidase activity  craniofacial suture morphogenesis  
Ontology : EGO-EBIendochondral ossification  metalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  Golgi lumen  plasma membrane  integral component of plasma membrane  proteolysis  proteolysis  enzyme activator activity  zinc ion binding  cell surface  protein processing  protein metabolic process  extracellular matrix disassembly  collagen catabolic process  chondrocyte proliferation  positive regulation of catalytic activity  embryonic cranial skeleton morphogenesis  metalloaminopeptidase activity  metalloaminopeptidase activity  craniofacial suture morphogenesis  
Pathways : KEGGMicroRNAs in cancer   
NDEx NetworkMMP16
Atlas of Cancer Signalling NetworkMMP16
Wikipedia pathwaysMMP16
Orthology - Evolution
OrthoDB4325
GeneTree (enSembl)ENSG00000156103
Phylogenetic Trees/Animal Genes : TreeFamMMP16
HOVERGENP51512
HOGENOMP51512
Homologs : HomoloGeneMMP16
Homology/Alignments : Family Browser (UCSC)MMP16
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP16
dbVarMMP16
ClinVarMMP16
1000_GenomesMMP16 
Exome Variant ServerMMP16
ExAC (Exome Aggregation Consortium)MMP16 (select the gene name)
Genetic variants : HAPMAP4325
Genomic Variants (DGV)MMP16 [DGVbeta]
DECIPHERMMP16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP16 
Mutations
ICGC Data PortalMMP16 
TCGA Data PortalMMP16 
Broad Tumor PortalMMP16
OASIS PortalMMP16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP16
DgiDB (Drug Gene Interaction Database)MMP16
DoCM (Curated mutations)MMP16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP16 (select a term)
intoGenMMP16
Cancer3DMMP16(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602262   
Orphanet
MedgenMMP16
Genetic Testing Registry MMP16
NextProtP51512 [Medical]
TSGene4325
GENETestsMMP16
Target ValidationMMP16
Huge Navigator MMP16 [HugePedia]
snp3D : Map Gene to Disease4325
BioCentury BCIQMMP16
ClinGenMMP16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4325
Chemical/Pharm GKB GenePA30874
Clinical trialMMP16
Miscellaneous
canSAR (ICR)MMP16 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP16
EVEXMMP16
GoPubMedMMP16
iHOPMMP16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:08:03 CEST 2017

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