Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MMP16 (matrix metallopeptidase 16)

Identity

Alias (NCBI)C8orf57
MMP-X2
MT-MMP2
MT-MMP3
MT3-MMP
HGNC (Hugo) MMP16
HGNC Alias symbMT3-MMP
DKFZp761D112
HGNC Previous nameC8orf57
HGNC Previous namematrix metalloproteinase 16 (membrane-inserted)
 chromosome 8 open reading frame 57
 matrix metallopeptidase 16 (membrane-inserted)
LocusID (NCBI) 4325
Atlas_Id 41393
Location 8q21.3  [Link to chromosome band 8q21]
Location_base_pair Starts at 88032014 and ends at 88327483 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MMP16 (8q21.3)::ANKRD13A (12q24.11)MMP16 (8q21.3)::EIF3E (8q23.1)PAX3 (2q36.1)::MMP16 (8q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MMP16   7162
Cards
Entrez_Gene (NCBI)MMP16    matrix metallopeptidase 16
AliasesC8orf57; MMP-X2; MT-MMP2; MT-MMP3; 
MT3-MMP
GeneCards (Weizmann)MMP16
Ensembl hg19 (Hinxton)ENSG00000156103 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156103 [Gene_View]  ENSG00000156103 [Sequence]  chr8:88032014-88327483 [Contig_View]  MMP16 [Vega]
ICGC DataPortalENSG00000156103
TCGA cBioPortalMMP16
AceView (NCBI)MMP16
Genatlas (Paris)MMP16
SOURCE (Princeton)MMP16
Genetics Home Reference (NIH)MMP16
Genomic and cartography
GoldenPath hg38 (UCSC)MMP16  -     chr8:88032014-88327483 -  8q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP16  -     8q21.3   [Description]    (hg19-Feb_2009)
GoldenPathMMP16 - 8q21.3 [CytoView hg19]  MMP16 - 8q21.3 [CytoView hg38]
ImmunoBaseENSG00000156103
Genome Data Viewer NCBIMMP16 [Mapview hg19]  
OMIM602262   
Gene and transcription
Genbank (Entrez)AB009303 AK314274 AL136588 AL832595 BC069500
RefSeq transcript (Entrez)NM_005941 NM_022564 NM_032297
Consensus coding sequences : CCDS (NCBI)MMP16
Gene ExpressionMMP16 [ NCBI-GEO ]   MMP16 [ EBI - ARRAY_EXPRESS ]   MMP16 [ SEEK ]   MMP16 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP16 [ Firebrowse - Broad ]
GenevisibleExpression of MMP16 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4325
GTEX Portal (Tissue expression)MMP16
Human Protein AtlasENSG00000156103-MMP16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51512   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51512  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51512
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP51512
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_dom_sf    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom_sf    MMP16    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_metallopeptidase_C    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like    PGBD-like_sf   
Domain families : Pfam (Sanger)DUF3377 (PF11857)    Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam11857    pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP16
PDB (RSDB)1RM8   
PDB Europe1RM8   
PDB (PDBSum)1RM8   
PDB (IMB)1RM8   
Structural Biology KnowledgeBase1RM8   
SCOP (Structural Classification of Proteins)1RM8   
CATH (Classification of proteins structures)1RM8   
SuperfamilyP51512
AlphaFold pdb e-kbP51512   
Human Protein Atlas [tissue]ENSG00000156103-MMP16 [tissue]
HPRD03776
Protein Interaction databases
DIP (DOE-UCLA)P51512
IntAct (EBI)P51512
BioGRIDMMP16
STRING (EMBL)MMP16
ZODIACMMP16
Ontologies - Pathways
QuickGOP51512
Ontology : AmiGOskeletal system development  endochondral ossification  metalloendopeptidase activity  metalloendopeptidase activity  extracellular region  Golgi lumen  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  proteolysis  proteolysis  enzyme activator activity  zinc ion binding  cell surface  protein processing  protein processing  extracellular matrix organization  collagen catabolic process  extracellular matrix  chondrocyte proliferation  embryonic cranial skeleton morphogenesis  regulation of catalytic activity  metalloaminopeptidase activity  metalloaminopeptidase activity  craniofacial suture morphogenesis  
Ontology : EGO-EBIskeletal system development  endochondral ossification  metalloendopeptidase activity  metalloendopeptidase activity  extracellular region  Golgi lumen  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  proteolysis  proteolysis  enzyme activator activity  zinc ion binding  cell surface  protein processing  protein processing  extracellular matrix organization  collagen catabolic process  extracellular matrix  chondrocyte proliferation  embryonic cranial skeleton morphogenesis  regulation of catalytic activity  metalloaminopeptidase activity  metalloaminopeptidase activity  craniofacial suture morphogenesis  
NDEx NetworkMMP16
Atlas of Cancer Signalling NetworkMMP16
Wikipedia pathwaysMMP16
Orthology - Evolution
OrthoDB4325
GeneTree (enSembl)ENSG00000156103
Phylogenetic Trees/Animal Genes : TreeFamMMP16
Homologs : HomoloGeneMMP16
Homology/Alignments : Family Browser (UCSC)MMP16
Gene fusions - Rearrangements
Fusion : QuiverMMP16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP16
dbVarMMP16
ClinVarMMP16
MonarchMMP16
1000_GenomesMMP16 
Exome Variant ServerMMP16
GNOMAD BrowserENSG00000156103
Varsome BrowserMMP16
ACMGMMP16 variants
VarityP51512
Genomic Variants (DGV)MMP16 [DGVbeta]
DECIPHERMMP16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP16 
Mutations
ICGC Data PortalMMP16 
TCGA Data PortalMMP16 
Broad Tumor PortalMMP16
OASIS PortalMMP16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP16  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMMP16
Mutations and Diseases : HGMDMMP16
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMMP16
DgiDB (Drug Gene Interaction Database)MMP16
DoCM (Curated mutations)MMP16
CIViC (Clinical Interpretations of Variants in Cancer)MMP16
Cancer3DMMP16
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602262   
Orphanet
DisGeNETMMP16
MedgenMMP16
Genetic Testing Registry MMP16
NextProtP51512 [Medical]
GENETestsMMP16
Target ValidationMMP16
Huge Navigator MMP16 [HugePedia]
ClinGenMMP16
Clinical trials, drugs, therapy
MyCancerGenomeMMP16
Protein Interactions : CTDMMP16
Pharm GKB GenePA30874
PharosP51512
Clinical trialMMP16
Miscellaneous
canSAR (ICR)MMP16
HarmonizomeMMP16
ARCHS4MMP16
DataMed IndexMMP16
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMMP16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:47:26 CET 2022

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