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MMP17 (matrix metallopeptidase 17)

Identity

Alias_namesmatrix metalloproteinase 17 (membrane-inserted)
matrix metallopeptidase 17 (membrane-inserted)
Alias_symbol (synonym)MT4-MMP
Other aliasMMP-17
MT4MMP
MTMMP4
HGNC (Hugo) MMP17
LocusID (NCBI) 4326
Atlas_Id 41394
Location 12q24.33  [Link to chromosome band 12q24]
Location_base_pair Starts at 131828393 and ends at 131851771 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP17   7163
Cards
Entrez_Gene (NCBI)MMP17  4326  matrix metallopeptidase 17
AliasesMMP-17; MT4-MMP; MT4MMP; MTMMP4
GeneCards (Weizmann)MMP17
Ensembl hg19 (Hinxton)ENSG00000198598 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198598 [Gene_View]  chr12:131828393-131851771 [Contig_View]  MMP17 [Vega]
ICGC DataPortalENSG00000198598
TCGA cBioPortalMMP17
AceView (NCBI)MMP17
Genatlas (Paris)MMP17
WikiGenes4326
SOURCE (Princeton)MMP17
Genetics Home Reference (NIH)MMP17
Genomic and cartography
GoldenPath hg38 (UCSC)MMP17  -     chr12:131828393-131851771 +  12q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP17  -     12q24.33   [Description]    (hg19-Feb_2009)
EnsemblMMP17 - 12q24.33 [CytoView hg19]  MMP17 - 12q24.33 [CytoView hg38]
Mapping of homologs : NCBIMMP17 [Mapview hg19]  MMP17 [Mapview hg38]
OMIM602285   
Gene and transcription
Genbank (Entrez)AB021225 BC040507 BC045610 BQ227546 BX389435
RefSeq transcript (Entrez)NM_016155
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP17
Cluster EST : UnigeneHs.709245 [ NCBI ]
CGAP (NCI)Hs.709245
Alternative Splicing GalleryENSG00000198598
Gene ExpressionMMP17 [ NCBI-GEO ]   MMP17 [ EBI - ARRAY_EXPRESS ]   MMP17 [ SEEK ]   MMP17 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4326
GTEX Portal (Tissue expression)MMP17
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULZ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULZ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULZ9
Splice isoforms : SwissVarQ9ULZ9
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9ULZ9
Domaine pattern : Prosite (Expaxy)HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    M10A_MMP    MetalloPept_cat_dom    MMP17    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_stromelysin-type    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP17
DMDM Disease mutations4326
Blocks (Seattle)MMP17
SuperfamilyQ9ULZ9
Human Protein AtlasENSG00000198598
Peptide AtlasQ9ULZ9
HPRD03793
IPIIPI00472696   IPI00008533   IPI01014425   IPI01014914   IPI01016039   IPI01011750   IPI00789522   IPI01012477   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULZ9
IntAct (EBI)Q9ULZ9
FunCoupENSG00000198598
BioGRIDMMP17
STRING (EMBL)MMP17
ZODIACMMP17
Ontologies - Pathways
QuickGOQ9ULZ9
Ontology : AmiGOkidney development  metalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  integral component of plasma membrane  proteolysis  enzyme activator activity  zinc ion binding  anchored component of membrane  drinking behavior  positive regulation of catalytic activity  metalloaminopeptidase activity  
Ontology : EGO-EBIkidney development  metalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  integral component of plasma membrane  proteolysis  enzyme activator activity  zinc ion binding  anchored component of membrane  drinking behavior  positive regulation of catalytic activity  metalloaminopeptidase activity  
NDEx NetworkMMP17
Atlas of Cancer Signalling NetworkMMP17
Wikipedia pathwaysMMP17
Orthology - Evolution
OrthoDB4326
GeneTree (enSembl)ENSG00000198598
Phylogenetic Trees/Animal Genes : TreeFamMMP17
HOVERGENQ9ULZ9
HOGENOMQ9ULZ9
Homologs : HomoloGeneMMP17
Homology/Alignments : Family Browser (UCSC)MMP17
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP17
dbVarMMP17
ClinVarMMP17
1000_GenomesMMP17 
Exome Variant ServerMMP17
ExAC (Exome Aggregation Consortium)MMP17 (select the gene name)
Genetic variants : HAPMAP4326
Genomic Variants (DGV)MMP17 [DGVbeta]
DECIPHERMMP17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP17 
Mutations
ICGC Data PortalMMP17 
TCGA Data PortalMMP17 
Broad Tumor PortalMMP17
OASIS PortalMMP17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP17  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP17
DgiDB (Drug Gene Interaction Database)MMP17
DoCM (Curated mutations)MMP17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP17 (select a term)
intoGenMMP17
Cancer3DMMP17(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602285   
Orphanet
MedgenMMP17
Genetic Testing Registry MMP17
NextProtQ9ULZ9 [Medical]
TSGene4326
GENETestsMMP17
Target ValidationMMP17
Huge Navigator MMP17 [HugePedia]
snp3D : Map Gene to Disease4326
BioCentury BCIQMMP17
ClinGenMMP17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4326
Chemical/Pharm GKB GenePA30875
Clinical trialMMP17
Miscellaneous
canSAR (ICR)MMP17 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP17
EVEXMMP17
GoPubMedMMP17
iHOPMMP17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:08:03 CEST 2017

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