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MMP21 (matrix metallopeptidase 21)

Identity

Alias_namesmatrix metalloproteinase 21
Other aliasHTX7
MMP-21
HGNC (Hugo) MMP21
LocusID (NCBI) 118856
Atlas_Id 41398
Location 10q26.2  [Link to chromosome band 10q26]
Location_base_pair Starts at 125766456 and ends at 125775821 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP21   14357
Cards
Entrez_Gene (NCBI)MMP21  118856  matrix metallopeptidase 21
AliasesHTX7; MMP-21
GeneCards (Weizmann)MMP21
Ensembl hg19 (Hinxton)ENSG00000154485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154485 [Gene_View]  ENSG00000154485 [Sequence]  chr10:125766456-125775821 [Contig_View]  MMP21 [Vega]
ICGC DataPortalENSG00000154485
TCGA cBioPortalMMP21
AceView (NCBI)MMP21
Genatlas (Paris)MMP21
WikiGenes118856
SOURCE (Princeton)MMP21
Genetics Home Reference (NIH)MMP21
Genomic and cartography
GoldenPath hg38 (UCSC)MMP21  -     chr10:125766456-125775821 -  10q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP21  -     10q26.2   [Description]    (hg19-Feb_2009)
EnsemblMMP21 - 10q26.2 [CytoView hg19]  MMP21 - 10q26.2 [CytoView hg38]
Mapping of homologs : NCBIMMP21 [Mapview hg19]  MMP21 [Mapview hg38]
OMIM608416   616749   
Gene and transcription
Genbank (Entrez)AF331526 AF520613
RefSeq transcript (Entrez)NM_147191
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP21
Cluster EST : UnigeneHs.314141 [ NCBI ]
CGAP (NCI)Hs.314141
Alternative Splicing GalleryENSG00000154485
Gene ExpressionMMP21 [ NCBI-GEO ]   MMP21 [ EBI - ARRAY_EXPRESS ]   MMP21 [ SEEK ]   MMP21 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)118856
GTEX Portal (Tissue expression)MMP21
Human Protein AtlasENSG00000154485-MMP21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N119   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N119  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N119
Splice isoforms : SwissVarQ8N119
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ8N119
Domaine pattern : Prosite (Expaxy)HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_dom_sf    Hemopexin-like_repeat    M10A_MMP    MetalloPept_cat_dom_sf    Pept_M10_metallopeptidase    Pept_M10A    Peptidase_Metallo    Peptidoglycan-bd-like    PGBD-like_sf   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP21
DMDM Disease mutations118856
Blocks (Seattle)MMP21
SuperfamilyQ8N119
Human Protein Atlas [tissue]ENSG00000154485-MMP21 [tissue]
Peptide AtlasQ8N119
HPRD07003
IPIIPI00295606   
Protein Interaction databases
DIP (DOE-UCLA)Q8N119
IntAct (EBI)Q8N119
FunCoupENSG00000154485
BioGRIDMMP21
STRING (EMBL)MMP21
ZODIACMMP21
Ontologies - Pathways
QuickGOQ8N119
Ontology : AmiGOhematopoietic progenitor cell differentiation  metalloendopeptidase activity  proteolysis  determination of left/right symmetry  metallopeptidase activity  zinc ion binding  extracellular matrix  coronary vasculature development  determination of heart left/right asymmetry  determination of heart left/right asymmetry  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  metalloendopeptidase activity  proteolysis  determination of left/right symmetry  metallopeptidase activity  zinc ion binding  extracellular matrix  coronary vasculature development  determination of heart left/right asymmetry  determination of heart left/right asymmetry  
NDEx NetworkMMP21
Atlas of Cancer Signalling NetworkMMP21
Wikipedia pathwaysMMP21
Orthology - Evolution
OrthoDB118856
GeneTree (enSembl)ENSG00000154485
Phylogenetic Trees/Animal Genes : TreeFamMMP21
HOVERGENQ8N119
HOGENOMQ8N119
Homologs : HomoloGeneMMP21
Homology/Alignments : Family Browser (UCSC)MMP21
Gene fusions - Rearrangements
Fusion : QuiverMMP21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP21
dbVarMMP21
ClinVarMMP21
1000_GenomesMMP21 
Exome Variant ServerMMP21
ExAC (Exome Aggregation Consortium)ENSG00000154485
GNOMAD BrowserENSG00000154485
Varsome BrowserMMP21
Genetic variants : HAPMAP118856
Genomic Variants (DGV)MMP21 [DGVbeta]
DECIPHERMMP21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP21 
Mutations
ICGC Data PortalMMP21 
TCGA Data PortalMMP21 
Broad Tumor PortalMMP21
OASIS PortalMMP21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP21
DgiDB (Drug Gene Interaction Database)MMP21
DoCM (Curated mutations)MMP21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP21 (select a term)
intoGenMMP21
Cancer3DMMP21(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608416    616749   
Orphanet17142    14774   
DisGeNETMMP21
MedgenMMP21
Genetic Testing Registry MMP21
NextProtQ8N119 [Medical]
TSGene118856
GENETestsMMP21
Target ValidationMMP21
Huge Navigator MMP21 [HugePedia]
snp3D : Map Gene to Disease118856
BioCentury BCIQMMP21
ClinGenMMP21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD118856
Chemical/Pharm GKB GenePA134885721
Clinical trialMMP21
Miscellaneous
canSAR (ICR)MMP21 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP21
EVEXMMP21
GoPubMedMMP21
iHOPMMP21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:23:24 CET 2018

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