Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MMP24 (matrix metallopeptidase 24)

Identity

Alias_namesmatrix metalloproteinase 24 (membrane-inserted)
matrix metallopeptidase 24 (membrane-inserted)
Alias_symbol (synonym)MT5-MMP
Other aliasMMP-24
MMP25
MT-MMP 5
MT-MMP5
MT5MMP
MTMMP5
HGNC (Hugo) MMP24
LocusID (NCBI) 10893
Atlas_Id 41401
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 35226736 and ends at 35277001 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADNP (20q13.13) / MMP24 (20q11.22)ADNP 20q13.13 / MMP24 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(20;20)(q11;q13) ADNP/MMP24

External links

Nomenclature
HGNC (Hugo)MMP24   7172
Cards
Entrez_Gene (NCBI)MMP24  10893  matrix metallopeptidase 24
AliasesMMP-24; MMP25; MT-MMP; MT-MMP5; 
MT5-MMP; MT5MMP; MTMMP5
GeneCards (Weizmann)MMP24
Ensembl hg19 (Hinxton)ENSG00000125966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125966 [Gene_View]  ENSG00000125966 [Sequence]  chr20:35226736-35277001 [Contig_View]  MMP24 [Vega]
ICGC DataPortalENSG00000125966
TCGA cBioPortalMMP24
AceView (NCBI)MMP24
Genatlas (Paris)MMP24
WikiGenes10893
SOURCE (Princeton)MMP24
Genetics Home Reference (NIH)MMP24
Genomic and cartography
GoldenPath hg38 (UCSC)MMP24  -     chr20:35226736-35277001 +  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP24  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblMMP24 - 20q11.22 [CytoView hg19]  MMP24 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIMMP24 [Mapview hg19]  MMP24 [Mapview hg38]
OMIM604871   
Gene and transcription
Genbank (Entrez)AB021227 AF131284 BC047614 DQ300264 R60687
RefSeq transcript (Entrez)NM_006690
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP24
Cluster EST : UnigeneHs.715494 [ NCBI ]
CGAP (NCI)Hs.715494
Alternative Splicing GalleryENSG00000125966
Gene ExpressionMMP24 [ NCBI-GEO ]   MMP24 [ EBI - ARRAY_EXPRESS ]   MMP24 [ SEEK ]   MMP24 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP24 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10893
GTEX Portal (Tissue expression)MMP24
Human Protein AtlasENSG00000125966-MMP24 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5R2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5R2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5R2
Splice isoforms : SwissVarQ9Y5R2
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9Y5R2
Domaine pattern : Prosite (Expaxy)HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom    MMP24    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_metallopeptidase_C    Pept_M10A_stromelysin-type    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)DUF3377 (PF11857)    Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam11857    pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP24
DMDM Disease mutations10893
Blocks (Seattle)MMP24
SuperfamilyQ9Y5R2
Human Protein Atlas [tissue]ENSG00000125966-MMP24 [tissue]
Peptide AtlasQ9Y5R2
HPRD05338
IPIIPI00001729   IPI01009653   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5R2
IntAct (EBI)Q9Y5R2
FunCoupENSG00000125966
BioGRIDMMP24
STRING (EMBL)MMP24
ZODIACMMP24
Ontologies - Pathways
QuickGOQ9Y5R2
Ontology : AmiGOmetalloendopeptidase activity  proteinaceous extracellular matrix  integral component of plasma membrane  proteolysis  enzyme activator activity  zinc ion binding  glial cell differentiation  trans-Golgi network membrane  positive regulation of catalytic activity  cell-cell adhesion mediated by cadherin  cadherin binding  detection of temperature stimulus involved in sensory perception of pain  extracellular exosome  neuronal stem cell population maintenance  cell-cell adhesion via plasma-membrane adhesion molecules  
Ontology : EGO-EBImetalloendopeptidase activity  proteinaceous extracellular matrix  integral component of plasma membrane  proteolysis  enzyme activator activity  zinc ion binding  glial cell differentiation  trans-Golgi network membrane  positive regulation of catalytic activity  cell-cell adhesion mediated by cadherin  cadherin binding  detection of temperature stimulus involved in sensory perception of pain  extracellular exosome  neuronal stem cell population maintenance  cell-cell adhesion via plasma-membrane adhesion molecules  
NDEx NetworkMMP24
Atlas of Cancer Signalling NetworkMMP24
Wikipedia pathwaysMMP24
Orthology - Evolution
OrthoDB10893
GeneTree (enSembl)ENSG00000125966
Phylogenetic Trees/Animal Genes : TreeFamMMP24
HOVERGENQ9Y5R2
HOGENOMQ9Y5R2
Homologs : HomoloGeneMMP24
Homology/Alignments : Family Browser (UCSC)MMP24
Gene fusions - Rearrangements
Fusion : MitelmanADNP/MMP24 [20q13.13/20q11.22]  [t(20;20)(q11;q13)]  
Fusion PortalADNP 20q13.13 MMP24 20q11.22 BRCA
Fusion : QuiverMMP24
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP24 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP24
dbVarMMP24
ClinVarMMP24
1000_GenomesMMP24 
Exome Variant ServerMMP24
ExAC (Exome Aggregation Consortium)ENSG00000125966
GNOMAD BrowserENSG00000125966
Genetic variants : HAPMAP10893
Genomic Variants (DGV)MMP24 [DGVbeta]
DECIPHERMMP24 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP24 
Mutations
ICGC Data PortalMMP24 
TCGA Data PortalMMP24 
Broad Tumor PortalMMP24
OASIS PortalMMP24 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP24  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP24
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP24
DgiDB (Drug Gene Interaction Database)MMP24
DoCM (Curated mutations)MMP24 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP24 (select a term)
intoGenMMP24
Cancer3DMMP24(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604871   
Orphanet
DisGeNETMMP24
MedgenMMP24
Genetic Testing Registry MMP24
NextProtQ9Y5R2 [Medical]
TSGene10893
GENETestsMMP24
Target ValidationMMP24
Huge Navigator MMP24 [HugePedia]
snp3D : Map Gene to Disease10893
BioCentury BCIQMMP24
ClinGenMMP24
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10893
Chemical/Pharm GKB GenePA30881
Clinical trialMMP24
Miscellaneous
canSAR (ICR)MMP24 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP24
EVEXMMP24
GoPubMedMMP24
iHOPMMP24
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:38:17 CEST 2018
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