Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MMP25 (matrix metallopeptidase 25)

Identity

Alias_namesMMPL1
MMP20
matrix metalloproteinase 25
matrix metallopeptidase-like 1
Alias_symbol (synonym)MT6-MMP
Other aliasMMP-25
MMP20A
MT-MMP 6
MT-MMP6
MT6MMP
MTMMP6
HGNC (Hugo) MMP25
LocusID (NCBI) 64386
Atlas_Id 41402
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3046681 and ends at 3060723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ZNF500 (16p13.3) / MMP25 (16p13.3)ZNF500 16p13.3 / MMP25 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP25   14246
Cards
Entrez_Gene (NCBI)MMP25  64386  matrix metallopeptidase 25
AliasesMMP-25; MMP20; MMP20A; MMPL1; 
MT-MMP; MT-MMP6; MT6-MMP; MT6MMP; MTMMP6
GeneCards (Weizmann)MMP25
Ensembl hg19 (Hinxton)ENSG00000008516 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008516 [Gene_View]  chr16:3046681-3060723 [Contig_View]  MMP25 [Vega]
ICGC DataPortalENSG00000008516
TCGA cBioPortalMMP25
AceView (NCBI)MMP25
Genatlas (Paris)MMP25
WikiGenes64386
SOURCE (Princeton)MMP25
Genetics Home Reference (NIH)MMP25
Genomic and cartography
GoldenPath hg38 (UCSC)MMP25  -     chr16:3046681-3060723 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP25  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblMMP25 - 16p13.3 [CytoView hg19]  MMP25 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIMMP25 [Mapview hg19]  MMP25 [Mapview hg38]
OMIM608482   
Gene and transcription
Genbank (Entrez)AB042328 AF145442 AF185270 AJ003144 AJ239053
RefSeq transcript (Entrez)NM_004142 NM_022468 NM_022718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP25
Cluster EST : UnigeneHs.654979 [ NCBI ]
CGAP (NCI)Hs.654979
Alternative Splicing GalleryENSG00000008516
Gene ExpressionMMP25 [ NCBI-GEO ]   MMP25 [ EBI - ARRAY_EXPRESS ]   MMP25 [ SEEK ]   MMP25 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64386
GTEX Portal (Tissue expression)MMP25
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPA2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPA2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPA2
Splice isoforms : SwissVarQ9NPA2
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9NPA2
Domaine pattern : Prosite (Expaxy)HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    M10A_MMP    MetalloPept_cat_dom    MMP25    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_stromelysin-type    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP25
DMDM Disease mutations64386
Blocks (Seattle)MMP25
SuperfamilyQ9NPA2
Human Protein AtlasENSG00000008516
Peptide AtlasQ9NPA2
HPRD07090
IPIIPI00014758   IPI00182491   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPA2
IntAct (EBI)Q9NPA2
FunCoupENSG00000008516
BioGRIDMMP25
STRING (EMBL)MMP25
ZODIACMMP25
Ontologies - Pathways
QuickGOQ9NPA2
Ontology : AmiGOmetalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  plasma membrane  proteolysis  inflammatory response  zinc ion binding  membrane  integral component of membrane  anchored component of membrane  specific granule membrane  neutrophil degranulation  hard palate development  
Ontology : EGO-EBImetalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  plasma membrane  proteolysis  inflammatory response  zinc ion binding  membrane  integral component of membrane  anchored component of membrane  specific granule membrane  neutrophil degranulation  hard palate development  
NDEx NetworkMMP25
Atlas of Cancer Signalling NetworkMMP25
Wikipedia pathwaysMMP25
Orthology - Evolution
OrthoDB64386
GeneTree (enSembl)ENSG00000008516
Phylogenetic Trees/Animal Genes : TreeFamMMP25
HOVERGENQ9NPA2
HOGENOMQ9NPA2
Homologs : HomoloGeneMMP25
Homology/Alignments : Family Browser (UCSC)MMP25
Gene fusions - Rearrangements
Fusion : MitelmanZNF500/MMP25 [16p13.3/16p13.3]  [t(16;16)(p13;p13)]  
Fusion: TCGAZNF500 16p13.3 MMP25 16p13.3 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP25
dbVarMMP25
ClinVarMMP25
1000_GenomesMMP25 
Exome Variant ServerMMP25
ExAC (Exome Aggregation Consortium)MMP25 (select the gene name)
Genetic variants : HAPMAP64386
Genomic Variants (DGV)MMP25 [DGVbeta]
DECIPHERMMP25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP25 
Mutations
ICGC Data PortalMMP25 
TCGA Data PortalMMP25 
Broad Tumor PortalMMP25
OASIS PortalMMP25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP25
DgiDB (Drug Gene Interaction Database)MMP25
DoCM (Curated mutations)MMP25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP25 (select a term)
intoGenMMP25
Cancer3DMMP25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608482   
Orphanet
MedgenMMP25
Genetic Testing Registry MMP25
NextProtQ9NPA2 [Medical]
TSGene64386
GENETestsMMP25
Target ValidationMMP25
Huge Navigator MMP25 [HugePedia]
snp3D : Map Gene to Disease64386
BioCentury BCIQMMP25
ClinGenMMP25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64386
Chemical/Pharm GKB GenePA30882
Clinical trialMMP25
Miscellaneous
canSAR (ICR)MMP25 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP25
EVEXMMP25
GoPubMedMMP25
iHOPMMP25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:45:06 CEST 2017

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