Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MMP27 (matrix metallopeptidase 27)

Identity

Alias_namesmatrix metalloproteinase 27
Other aliasMMP-27
HGNC (Hugo) MMP27
LocusID (NCBI) 64066
Atlas_Id 41404
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102691684 and ends at 102705737 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TMEM123 (11q22.2) / MMP27 (11q22.2)TMEM123 11q22.2 / MMP27 11q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TMEM123/MMP27 (11q22)

External links

Nomenclature
HGNC (Hugo)MMP27   14250
Cards
Entrez_Gene (NCBI)MMP27  64066  matrix metallopeptidase 27
AliasesMMP-27
GeneCards (Weizmann)MMP27
Ensembl hg19 (Hinxton)ENSG00000137675 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137675 [Gene_View]  ENSG00000137675 [Sequence]  chr11:102691684-102705737 [Contig_View]  MMP27 [Vega]
ICGC DataPortalENSG00000137675
TCGA cBioPortalMMP27
AceView (NCBI)MMP27
Genatlas (Paris)MMP27
WikiGenes64066
SOURCE (Princeton)MMP27
Genetics Home Reference (NIH)MMP27
Genomic and cartography
GoldenPath hg38 (UCSC)MMP27  -     chr11:102691684-102705737 -  11q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP27  -     11q22.2   [Description]    (hg19-Feb_2009)
MMP27 - 11q22.2 [CytoView hg19]  MMP27 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP27 [Mapview hg19]  MMP27 [Mapview hg38]
OMIM618101   
Gene and transcription
Genbank (Entrez)AF195192 AY358752 BX102293
RefSeq transcript (Entrez)NM_022122
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP27
Cluster EST : UnigeneHs.534479 [ NCBI ]
CGAP (NCI)Hs.534479
Alternative Splicing GalleryENSG00000137675
Gene ExpressionMMP27 [ NCBI-GEO ]   MMP27 [ EBI - ARRAY_EXPRESS ]   MMP27 [ SEEK ]   MMP27 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64066
GTEX Portal (Tissue expression)MMP27
Human Protein AtlasENSG00000137675-MMP27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H306   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H306  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H306
Splice isoforms : SwissVarQ9H306
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9H306
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_dom_sf    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom_sf    MMP27    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like    PGBD-like_sf    PGBDSf   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP27
DMDM Disease mutations64066
Blocks (Seattle)MMP27
SuperfamilyQ9H306
Human Protein Atlas [tissue]ENSG00000137675-MMP27 [tissue]
Peptide AtlasQ9H306
HPRD07025
IPIIPI00005471   
Protein Interaction databases
DIP (DOE-UCLA)Q9H306
IntAct (EBI)Q9H306
FunCoupENSG00000137675
BioGRIDMMP27
STRING (EMBL)MMP27
ZODIACMMP27
Ontologies - Pathways
QuickGOQ9H306
Ontology : AmiGOmetalloendopeptidase activity  metalloendopeptidase activity  extracellular space  proteolysis  zinc ion binding  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  extrinsic component of endoplasmic reticulum membrane  
Ontology : EGO-EBImetalloendopeptidase activity  metalloendopeptidase activity  extracellular space  proteolysis  zinc ion binding  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  extrinsic component of endoplasmic reticulum membrane  
NDEx NetworkMMP27
Atlas of Cancer Signalling NetworkMMP27
Wikipedia pathwaysMMP27
Orthology - Evolution
OrthoDB64066
GeneTree (enSembl)ENSG00000137675
Phylogenetic Trees/Animal Genes : TreeFamMMP27
HOGENOMQ9H306
Homologs : HomoloGeneMMP27
Homology/Alignments : Family Browser (UCSC)MMP27
Gene fusions - Rearrangements
Fusion : MitelmanTMEM123/MMP27 [11q22.2/11q22.2]  [t(11;11)(q22;q22)]  
Fusion PortalTMEM123 11q22.2 MMP27 11q22.2 BRCA
Fusion : QuiverMMP27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP27
dbVarMMP27
ClinVarMMP27
1000_GenomesMMP27 
Exome Variant ServerMMP27
ExAC (Exome Aggregation Consortium)ENSG00000137675
GNOMAD BrowserENSG00000137675
Varsome BrowserMMP27
Genetic variants : HAPMAP64066
Genomic Variants (DGV)MMP27 [DGVbeta]
DECIPHERMMP27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP27 
Mutations
ICGC Data PortalMMP27 
TCGA Data PortalMMP27 
Broad Tumor PortalMMP27
OASIS PortalMMP27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP27
DgiDB (Drug Gene Interaction Database)MMP27
DoCM (Curated mutations)MMP27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP27 (select a term)
intoGenMMP27
Cancer3DMMP27(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618101   
Orphanet
DisGeNETMMP27
MedgenMMP27
Genetic Testing Registry MMP27
NextProtQ9H306 [Medical]
TSGene64066
GENETestsMMP27
Target ValidationMMP27
Huge Navigator MMP27 [HugePedia]
snp3D : Map Gene to Disease64066
BioCentury BCIQMMP27
ClinGenMMP27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64066
Chemical/Pharm GKB GenePA30884
Clinical trialMMP27
Miscellaneous
canSAR (ICR)MMP27 (select the gene name)
DataMed IndexMMP27
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP27
EVEXMMP27
GoPubMedMMP27
iHOPMMP27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:58:12 CET 2019
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