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MMP28 (matrix metallopeptidase 28)

Identity

Alias_namesmatrix metalloproteinase 28
Alias_symbol (synonym)MMP-25
MM28
EPILYSIN
MMP-28
Other aliasMMP25
HGNC (Hugo) MMP28
LocusID (NCBI) 79148
Atlas_Id 41405
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 34105509 and ends at 34122711 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MMP28 (17q12) / KCNJ12 (17p11.2)MMP28 17q12 / KCNJ12 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP28   14366
Cards
Entrez_Gene (NCBI)MMP28  79148  matrix metallopeptidase 28
AliasesEPILYSIN; MM28; MMP-25; MMP-28; 
MMP25
GeneCards (Weizmann)MMP28
Ensembl hg19 (Hinxton)ENSG00000271447 [Gene_View]  chr17:34105509-34122711 [Contig_View]  MMP28 [Vega]
Ensembl hg38 (Hinxton)ENSG00000271447 [Gene_View]  chr17:34105509-34122711 [Contig_View]  MMP28 [Vega]
ICGC DataPortalENSG00000271447
TCGA cBioPortalMMP28
AceView (NCBI)MMP28
Genatlas (Paris)MMP28
WikiGenes79148
SOURCE (Princeton)MMP28
Genetics Home Reference (NIH)MMP28
Genomic and cartography
GoldenPath hg19 (UCSC)MMP28  -     chr17:34105509-34122711 -  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MMP28  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblMMP28 - 17q12 [CytoView hg19]  MMP28 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIMMP28 [Mapview hg19]  MMP28 [Mapview hg38]
OMIM608417   
Gene and transcription
Genbank (Entrez)AA813101 AF219624 AF315683 AF330002 AK122604
RefSeq transcript (Entrez)NM_001032278 NM_024302 NM_032950
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NT_187614 NW_004929407
Consensus coding sequences : CCDS (NCBI)MMP28
Cluster EST : UnigeneHs.380710 [ NCBI ]
CGAP (NCI)Hs.380710
Alternative Splicing GalleryENSG00000271447
Gene ExpressionMMP28 [ NCBI-GEO ]   MMP28 [ EBI - ARRAY_EXPRESS ]   MMP28 [ SEEK ]   MMP28 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP28 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79148
GTEX Portal (Tissue expression)MMP28
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H239   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H239  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H239
Splice isoforms : SwissVarQ9H239
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9H239
Domaine pattern : Prosite (Expaxy)HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    MetalloPept_cat_dom    MMP28    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_stromelysin-type    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP28
DMDM Disease mutations79148
Blocks (Seattle)MMP28
SuperfamilyQ9H239
Human Protein AtlasENSG00000271447
Peptide AtlasQ9H239
HPRD07464
IPIIPI00425258   IPI00792702   IPI01010912   
Protein Interaction databases
DIP (DOE-UCLA)Q9H239
IntAct (EBI)Q9H239
FunCoupENSG00000271447
BioGRIDMMP28
STRING (EMBL)MMP28
ZODIACMMP28
Ontologies - Pathways
QuickGOQ9H239
Ontology : AmiGOmetalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  cytoplasm  proteolysis  zinc ion binding  negative regulation of macrophage chemotaxis  
Ontology : EGO-EBImetalloendopeptidase activity  calcium ion binding  proteinaceous extracellular matrix  cytoplasm  proteolysis  zinc ion binding  negative regulation of macrophage chemotaxis  
NDEx NetworkMMP28
Atlas of Cancer Signalling NetworkMMP28
Wikipedia pathwaysMMP28
Orthology - Evolution
OrthoDB79148
GeneTree (enSembl)ENSG00000271447
Phylogenetic Trees/Animal Genes : TreeFamMMP28
HOVERGENQ9H239
HOGENOMQ9H239
Homologs : HomoloGeneMMP28
Homology/Alignments : Family Browser (UCSC)MMP28
Gene fusions - Rearrangements
Fusion : MitelmanMMP28/KCNJ12 [17q12/17p11.2]  
Fusion: TCGAMMP28 17q12 KCNJ12 17p11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP28 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP28
dbVarMMP28
ClinVarMMP28
1000_GenomesMMP28 
Exome Variant ServerMMP28
ExAC (Exome Aggregation Consortium)MMP28 (select the gene name)
Genetic variants : HAPMAP79148
Genomic Variants (DGV)MMP28 [DGVbeta]
DECIPHER (Syndromes)17:34105509-34122711  ENSG00000271447
CONAN: Copy Number AnalysisMMP28 
Mutations
ICGC Data PortalMMP28 
TCGA Data PortalMMP28 
Broad Tumor PortalMMP28
OASIS PortalMMP28 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP28  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP28
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP28
DgiDB (Drug Gene Interaction Database)MMP28
DoCM (Curated mutations)MMP28 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP28 (select a term)
intoGenMMP28
Cancer3DMMP28(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608417   
Orphanet
MedgenMMP28
Genetic Testing Registry MMP28
NextProtQ9H239 [Medical]
TSGene79148
GENETestsMMP28
Huge Navigator MMP28 [HugePedia]
snp3D : Map Gene to Disease79148
BioCentury BCIQMMP28
ClinGenMMP28
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79148
Chemical/Pharm GKB GenePA30885
Clinical trialMMP28
Miscellaneous
canSAR (ICR)MMP28 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP28
EVEXMMP28
GoPubMedMMP28
iHOPMMP28
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:10:51 CEST 2017

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