MMP3 (matrix metallopeptidase 3)

2003-02-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CHDS6,MMP-3,SL-1,STMY,STMY1,STR1
FUSION GENES

Other Information

Locus ID:

NCBI: 4314
MIM: 185250
HGNC: 7173
Ensembl: ENSG00000149968

Variants:

dbSNP: 4314
ClinVar: 4314
TCGA: ENSG00000149968
COSMIC: MMP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149968ENST00000299855P08254
ENSG00000149968ENST00000434103H7C139
ENSG00000149968ENST00000524478E9PKX2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
EGFR Transactivation by GastrinREACTOMER-HSA-2179392
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD10190398
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA448970chlorthalidoneChemicalClinicalAnnotationassociatedPD
PA450242lisinoprilChemicalClinicalAnnotationassociatedPD
PA451089pravastatinChemicalClinicalAnnotationassociatedPD10190398

References

Pubmed IDYearTitleCitations
203858262010Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).199
124779412002Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120093312002Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.75
188184372008Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines.71
119886252002Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study.64
158634972005Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.63
181720132008Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene.58
252174762015Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.58
161582512005Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model.57

Citation

Dessen P

MMP3 (matrix metallopeptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41406/mmp3