Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MMP3 (matrix metallopeptidase 3)

Identity

Alias_namesSTMY1
STMY
matrix metalloproteinase 3 (stromelysin 1, progelatinase)
stromelysin 1
Other aliasCHDS6
MMP-3
SL-1
STR1
HGNC (Hugo) MMP3
LocusID (NCBI) 4314
Atlas_Id 41406
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102835797 and ends at 102843689 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD74 (5q32) / MMP3 (11q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MMP3   7173
Cards
Entrez_Gene (NCBI)MMP3  4314  matrix metallopeptidase 3
AliasesCHDS6; MMP-3; SL-1; STMY; 
STMY1; STR1
GeneCards (Weizmann)MMP3
Ensembl hg19 (Hinxton)ENSG00000149968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149968 [Gene_View]  ENSG00000149968 [Sequence]  chr11:102835797-102843689 [Contig_View]  MMP3 [Vega]
ICGC DataPortalENSG00000149968
TCGA cBioPortalMMP3
AceView (NCBI)MMP3
Genatlas (Paris)MMP3
WikiGenes4314
SOURCE (Princeton)MMP3
Genetics Home Reference (NIH)MMP3
Genomic and cartography
GoldenPath hg38 (UCSC)MMP3  -     chr11:102835797-102843689 -  11q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP3  -     11q22.2   [Description]    (hg19-Feb_2009)
EnsemblMMP3 - 11q22.2 [CytoView hg19]  MMP3 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP3 [Mapview hg19]  MMP3 [Mapview hg38]
OMIM185250   614466   
Gene and transcription
Genbank (Entrez)AI628953 AK223283 AK223291 AK313310 BC069676
RefSeq transcript (Entrez)NM_002422
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP3
Cluster EST : UnigeneHs.375129 [ NCBI ]
CGAP (NCI)Hs.375129
Alternative Splicing GalleryENSG00000149968
Gene ExpressionMMP3 [ NCBI-GEO ]   MMP3 [ EBI - ARRAY_EXPRESS ]   MMP3 [ SEEK ]   MMP3 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4314
GTEX Portal (Tissue expression)MMP3
Human Protein AtlasENSG00000149968-MMP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08254   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08254  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08254
Splice isoforms : SwissVarP08254
Catalytic activity : Enzyme3.4.24.17 [ Enzyme-Expasy ]   3.4.24.173.4.24.17 [ IntEnz-EBI ]   3.4.24.17 [ BRENDA ]   3.4.24.17 [ KEGG ]   
PhosPhoSitePlusP08254
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_dom_sf    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom_sf    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like    PGBD-like_sf   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP3
DMDM Disease mutations4314
Blocks (Seattle)MMP3
PDB (RSDB)1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
PDB Europe1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
PDB (PDBSum)1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
PDB (IMB)1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
Structural Biology KnowledgeBase1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
SCOP (Structural Classification of Proteins)1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
CATH (Classification of proteins structures)1B3D    1B8Y    1BIW    1BM6    1BQO    1C3I    1C8T    1CAQ    1CIZ    1CQR    1D5J    1D7X    1D8F    1D8M    1G05    1G49    1G4K    1HFS    1HY7    1M1W    1OO9    1QIA    1QIC    1SLM    1SLN    1UEA    1UMS    1UMT    1USN    2D1O    2JNP    2JT5    2JT6    2SRT    2USN    3OHL    3OHO    3USN    4DPE    4G9L    4JA1   
SuperfamilyP08254
Human Protein Atlas [tissue]ENSG00000149968-MMP3 [tissue]
Peptide AtlasP08254
HPRD01703
IPIIPI00027782   IPI00789207   IPI00977699   
Protein Interaction databases
DIP (DOE-UCLA)P08254
IntAct (EBI)P08254
FunCoupENSG00000149968
BioGRIDMMP3
STRING (EMBL)MMP3
ZODIACMMP3
Ontologies - Pathways
QuickGOP08254
Ontology : AmiGOendopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  proteolysis  metallopeptidase activity  zinc ion binding  negative regulation of hydrogen peroxide metabolic process  cytokine-mediated signaling pathway  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  positive regulation of protein oligomerization  cellular response to nitric oxide  regulation of neuroinflammatory response  positive regulation of oxidative stress-induced cell death  
Ontology : EGO-EBIendopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  proteolysis  metallopeptidase activity  zinc ion binding  negative regulation of hydrogen peroxide metabolic process  cytokine-mediated signaling pathway  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  positive regulation of protein oligomerization  cellular response to nitric oxide  regulation of neuroinflammatory response  positive regulation of oxidative stress-induced cell death  
Pathways : KEGGTNF signaling pathway    Transcriptional misregulation in cancer    Rheumatoid arthritis   
NDEx NetworkMMP3
Atlas of Cancer Signalling NetworkMMP3
Wikipedia pathwaysMMP3
Orthology - Evolution
OrthoDB4314
GeneTree (enSembl)ENSG00000149968
Phylogenetic Trees/Animal Genes : TreeFamMMP3
HOGENOMP08254
Homologs : HomoloGeneMMP3
Homology/Alignments : Family Browser (UCSC)MMP3
Gene fusions - Rearrangements
Fusion : QuiverMMP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP3
dbVarMMP3
ClinVarMMP3
1000_GenomesMMP3 
Exome Variant ServerMMP3
ExAC (Exome Aggregation Consortium)ENSG00000149968
GNOMAD BrowserENSG00000149968
Varsome BrowserMMP3
Genetic variants : HAPMAP4314
Genomic Variants (DGV)MMP3 [DGVbeta]
DECIPHERMMP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP3 
Mutations
ICGC Data PortalMMP3 
TCGA Data PortalMMP3 
Broad Tumor PortalMMP3
OASIS PortalMMP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP3
DgiDB (Drug Gene Interaction Database)MMP3
DoCM (Curated mutations)MMP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP3 (select a term)
intoGenMMP3
Cancer3DMMP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM185250    614466   
Orphanet
DisGeNETMMP3
MedgenMMP3
Genetic Testing Registry MMP3
NextProtP08254 [Medical]
TSGene4314
GENETestsMMP3
Target ValidationMMP3
Huge Navigator MMP3 [HugePedia]
snp3D : Map Gene to Disease4314
BioCentury BCIQMMP3
ClinGenMMP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4314
Chemical/Pharm GKB GenePA30886
Clinical trialMMP3
Miscellaneous
canSAR (ICR)MMP3 (select the gene name)
DataMed IndexMMP3
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP3
EVEXMMP3
GoPubMedMMP3
iHOPMMP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:25:49 CET 2019
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